Abstract:
:Genome duplications are important evolutionary events that impact the rate and spectrum of beneficial mutations and thus the rate of adaptation. Laboratory evolution experiments initiated with haploid Saccharomyces cerevisiae cultures repeatedly experience whole-genome duplication (WGD). We report recurrent genome duplication in 46 haploid yeast populations evolved for 4,000 generations. We find that WGD confers a fitness advantage, and this immediate fitness gain is accompanied by a shift in genomic and phenotypic evolution. The presence of ploidy-enriched targets of selection and structural variants reveals that autodiploids utilize adaptive paths inaccessible to haploids. We find that autodiploids accumulate recessive deleterious mutations, indicating an increased susceptibility for nonadaptive evolution. Finally, we report that WGD results in a reduced adaptation rate, indicating a trade-off between immediate fitness gains and long-term adaptability.
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Fisher KJ,Buskirk SW,Vignogna RC,Marad DA,Lang GIdoi
10.1371/journal.pgen.1007396subject
Has Abstractpub_date
2018-05-25 00:00:00pages
e1007396issue
5eissn
1553-7390issn
1553-7404pii
PGENETICS-D-18-00165journal_volume
14pub_type
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