Abstract:
BACKGROUND:In protein design, correct use of topology is among the initial and most critical feature. Meticulous selection of backbone topology aids in drastically reducing the structure search space. With ProLego, we present a server application to explore the component aspect of protein structures and provide an intuitive and efficient way to scan the protein topology space. RESULT:We have implemented in-house developed "topological representation" in an automated-pipeline to extract protein topology from given protein structure. Using the topology string, ProLego, compares topology against a non-redundant extensive topology database (ProLegoDB) as well as extracts constituent topological modules. The platform offers interactive topology visualization graphs. CONCLUSION:ProLego, provides an alternative but comprehensive way to scan and visualize protein topology along with an extensive database of protein topology. ProLego can be found at http://www.proteinlego.com.
journal_name
BMC Bioinformaticsjournal_title
BMC bioinformaticsauthors
Khan T,Panday SK,Ghosh Idoi
10.1186/s12859-018-2171-9subject
Has Abstractpub_date
2018-05-04 00:00:00pages
167issue
1issn
1471-2105pii
10.1186/s12859-018-2171-9journal_volume
19pub_type
杂志文章abstract:BACKGROUND:The PathoLogic program constructs Pathway/Genome databases by using a genome's annotation to predict the set of metabolic pathways present in an organism. PathoLogic determines the set of reactions composing those pathways from the enzymes annotated in the organism's genome. Most annotation efforts fail to a...
journal_title:BMC bioinformatics
pub_type: 杂志文章
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journal_title:BMC bioinformatics
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journal_title:BMC bioinformatics
pub_type: 杂志文章
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journal_title:BMC bioinformatics
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:BMC bioinformatics
pub_type: 杂志文章
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更新日期:2010-03-16 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2008-05-08 00:00:00
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pub_type: 杂志文章
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abstract::After publication of this supplement article. ...
journal_title:BMC bioinformatics
pub_type: 已发布勘误
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更新日期:2019-05-15 00:00:00
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更新日期:2016-12-05 00:00:00
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pub_type: 杂志文章
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更新日期:2012-12-13 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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