Abstract:
:Childhood acute lymphoblastic leukemia survival rates have increased remarkably during last decades due, in part, to intensive treatment protocols. However, therapy resistance and toxicity are still two important barriers to survival. In this context, pharmacoepigenetics arises as a tool to identify new predictive markers, required to guide clinicians on risk stratification and dose individualization. The present study reviews current evidence about miRNA implication on childhood acute lymphoblastic leukemia therapy resistance and toxicity. A total of 12 studies analyzing differential miRNA expression in relation to drug resistance and six studies exploring the association between miRNAs-related SNPs and drug-induced toxicities were identified. We pointed out to miR-125b together with miR-99a and/or miR-100 overexpression as markers of vincristine resistance and rs2114358 in mir-1206 as mucositis marker as the most promising results.
journal_name
Pharmacogenomicsjournal_title
Pharmacogenomicsauthors
Umerez M,Garcia-Obregon S,Martin-Guerrero I,Astigarraga I,Gutierrez-Camino A,Garcia-Orad Adoi
10.2217/pgs-2017-0164subject
Has Abstractpub_date
2018-03-01 00:00:00pages
361-373issue
4eissn
1462-2416issn
1744-8042journal_volume
19pub_type
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