Abstract:
:Parkinson's disease (PD) is unique among neurodegenerative disorders because a highly effective pharmacological symptomatic treatment is available. The marked variability in drug response and in adverse profiles associated with this treatment led to the search of genetic markers associated with these features. We present a review of the literature on PD pharmacogenetics to provide a critical discussion of the current findings, new approaches, limitations and recommendations for future research. Pharmacogenetics studies in this field have assessed several outcomes and genes, with special focus on dopaminergic genes, mainly DRD2, which is the most important receptor in nigrostriatal pathway. The heterogeneity in methodological strategies employed by different studies is impressive. The question of whether PD pharmacogenetics studies will improve clinical management by causing a shift from a trial-and-error approach to a pharmacological regimen that takes into account the individual variability remains an open question. Collaborative longitudinal studies with larger sample sizes, better outcome definitions and replication studies are required.
journal_name
Pharmacogenomicsjournal_title
Pharmacogenomicsauthors
Schumacher-Schuh AF,Rieder CR,Hutz MHdoi
10.2217/pgs.14.93subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1253-71issue
9eissn
1462-2416issn
1744-8042journal_volume
15pub_type
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