Abstract:
Introduction:This review summarizes the research conducted on botulinum toxin (BoTx) from 1943 to 1956 by a small group of Camp Detrick investigators and their staff. A systematic, cross-disciplinary approach was used to develop effective vaccines against this biological warfare threat agent. In response to the potential need for medical countermeasures against BoTx during World War II, the refinement of isolation and purification techniques for BoTx successfully led to the large-scale production of botulinum toxoid vaccines. In addition, the work at Camp Detrick provided the foundation for the subsequent use of BoTx as a tool for studying the trophic regulation of skeletal muscle within motor neuron terminals and, more recently, for elucidation of the intricate details of neurotransmitter release at the molecular level. Indirectly, Camp Detrick investigators also played a significant role in studies that culminated in the use of BoTx as a pharmaceutical product that has been approved by the U.S. Food and Drug Administration for treating movement disorders, autonomic dysfunctions, and other conditions. Methods:Online literature searches were performed with Google, Google Scholar, PubMed, the bibliography from the Camp Detrick technical library, and at the Defense Technical Information Center. Reference lists in some of the primary research publications and reviews also provided source material. Search terms included botulinum, botulinus, and Camp Detrick. References related to the subsequent impacts of the Camp Detrick results were selected and cited from reviews and primary references in the more recent literature. Notes on toxin nomenclature and potential sources of error in this study are presented. Results:The literature searches returned 27 citations of Camp Detrick authors, 24 of which were articles in peer-reviewed journals. The publications by these investigators included several disciplines such as biochemistry, immunology, pharmacology, physiology, and toxicology. A fundamental finding was the identification of critical nutritional components for improved growth of Clostridium botulinum and the increased production of BoTx serotype A. The purification processes that were developed at Camp Detrick allowed for the production of crystalline material to be scaled up for the manufacture of toxoid vaccine. Based on the research by Camp Detrick scientists, a toxoid supply of over 1 million units was available to vaccinate ~300,000 troops before the large-scale operations of D-Day. Conclusions:BoTx research during the period 1943 to 1956 resulted in refinements in the techniques for isolating and purifying the crystalline BoTx type A. These results led to the development and manufacture of a toxoid vaccine that was available in a sufficient quantity to protect ~300,000 warfighters in a large-scale military operation. One of the most important long-term consequences derived from the knowledge gained by the efforts at Camp Detrick was the development in the 1980s of safe and effective therapeutic uses for BoTx type A, the most lethal biological substance known.
journal_name
Mil Medjournal_title
Military medicineauthors
Lebeda FJ,Adler M,Dembek ZFdoi
10.1093/milmed/usx047subject
Has Abstractpub_date
2018-05-01 00:00:00pages
85-95issue
5-6eissn
0026-4075issn
1930-613Xpii
4840535journal_volume
183pub_type
历史文章,杂志文章,评审abstract::A complete dental examination is the basis for identifying the dental readiness of Air Force Reserve Command members. Historically, these were done on an infrequent basis. Recently, an annual dental examination has been mandated for all military members. Current dental personnel manning and resources are not sufficien...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.170.1.26
更新日期:2005-01-01 00:00:00
abstract::Academic medical centers (AMCs) have traditionally symbolized technological advancements and specialization in patient care. AMCs are defined as institutions that include at a minimum a hospital and associated clinics and a medical education role. Today, these institutions face a transition to managed care and radical...
journal_title:Military medicine
pub_type: 杂志文章,评审
doi:
更新日期:1999-08-01 00:00:00
abstract::The present study describes the sources of Air Force (AF) Family Advocacy Program referrals (N = 42,389) for child and spouse maltreatment between 2000 and 2004. Sources of referrals were stable over time, with military sources accounting for the majority of both child and spouse referrals. Most (85%) of spouse maltre...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.173.12.1203
更新日期:2008-12-01 00:00:00
abstract:Objective:Women are serving in the armed forces and deployed to areas of conflict in increasing numbers. Problems such as depressive symptoms and risks related to combat exposure can have negative effects on adjustment following service; understanding the relationship between these problems may contribute to strategies...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usx065
更新日期:2018-03-01 00:00:00
abstract::This study compared the effects of a higher protein supplement manufactured from milk vs. a commercially available higher carbohydrate supplement on serum markers of muscle damage, anaerobic exercise, choice reaction time, and body composition during 2 weekends of vigorous hikes with simulated mountain skirmishes. Thi...
journal_title:Military medicine
pub_type: 杂志文章,随机对照试验
doi:10.7205/milmed-d-11-00396
更新日期:2012-06-01 00:00:00
abstract::Active duty military personnel and civilian government employees are at risk for exposure to a variety of pathogens as they meet their mission requirements throughout the world. When they present with a systemic disease, the clinician must entertain a broad differential diagnosis due to the multitude of infectious, ne...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed-d-09-00017
更新日期:2010-05-01 00:00:00
abstract:Introduction:To develop a short form (SF) of the 45-item multidimensional Moral Injury Symptom Scale - Military Version (MISS-M) to use when screening for moral injury and monitoring treatment response in veterans and active duty military with PTSD. Methods:A total of 427 veterans and active duty military with PTSD sy...
journal_title:Military medicine
pub_type: 杂志文章,随机对照试验
doi:10.1093/milmed/usy017
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:Volunteering as a health promotion intervention is positively related to improved health and well-being in civilians and older adults. Yet, the impacts of participating in a community-based volunteering program on returning military veterans have not been studied, nor have the outcomes for veterans who hav...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-16-00150
更新日期:2017-07-01 00:00:00
abstract::Previous studies have linked the use of caffeine, nicotine, and alcohol to health complications and have also found that the use of these substances significantly covary. Given the prevalence of health problems of older adults, it is surprising that no studies to date have examined the co-occurrent use of alcohol, caf...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::Erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis are immune-mediated epidermal conditions with variable clinical presentations. Although their clinical presentations often overlap, they have distinct etiologies and potential outcomes, which necessitate specific management strategies. This ca...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usaa029
更新日期:2020-09-18 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed-d-11-00246
更新日期:2011-12-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章,评审
doi:
更新日期:2000-07-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usaa197
更新日期:2020-12-30 00:00:00
abstract::Several important questions are addressed herein. What is graduate medical education (GME), and what is research? What is the history of the association between GME and research? Why is research required for GME? What research is required for GME? How will health care reform affect GME and biomedical research? How muc...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::A medical readiness training exercise was conducted in conjunction with Task Force Bravo in Honduras during July and August 2000. Surgical teams from Madigan Army Medical Center performed 46 major pelvic reconstructive surgical procedures and treated more than 300 patients. The mission was an exceptional training oppo...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::We report on two patients with head and neck injuries, who remained asymptomatic after the earthquake for 1 and 2 years, respectively. They developed late transient ischemic neurological signs and eventually presented with complete occlusion of the internal carotid artery. They made a good recovery with medical treatm...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.169.7.556
更新日期:2004-07-01 00:00:00
abstract::A unique chronic obstructive pulmonary disease (COPD), provisionally called "mustard lung", which occurs as a late complication of sulfur mustard (SM) exposure among SM-exposed Iranians, is presently poorly characterized. This investigation evaluates p53 immunoreactivity in bronchial epithelium of individuals with his...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.172.1.70
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Medical error is the third leading cause of death in the United States, contributing to suboptimal care, serious patient injury, and mortality among beneficiaries in the Military Health System. Recent media reports have scrutinized the safety and quality of military healthcare, including surgical complicat...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usz330
更新日期:2020-03-02 00:00:00
abstract:PURPOSE:To explore response to vitamin D supplementation in active duty (AD) warfighters and translate findings into evidence-based health policy. BACKGROUND:Soldiers are at risk for musculoskeletal injuries and metabolic dysfunction that impact physical performance and military readiness; the link with low vitamin D ...
journal_title:Military medicine
pub_type: 杂志文章,随机对照试验
doi:10.1093/milmed/usy393
更新日期:2019-03-01 00:00:00
abstract::Epidemiological studies often have to rely on a participant's self-reporting of information. The validity of the self-report instrument is an important consideration in any study. The purpose of this investigation was to determine the validity of self-reported Army Physical Fitness Test (APFT) scores. The APFT is admi...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.172.2.115
更新日期:2007-02-01 00:00:00
abstract:UNLABELLED:The Department of Defense spends more than $50 million dollars a year on humanitarian assistance (HA) projects. Although the projects are perceived as beneficial, demonstrating sustainable long-term impact is not possible. METHODS:A seven-step monitoring and evaluation (M&E) process was adapted for this stu...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.172.4.339
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to report the device lessons learned from an emergency tourniquet program and, in particular, to emphasize analysis of discarded devices recovered after clinical use. METHODS:Discarded tourniquet devices were analyzed after use in emergency care of war casualties to determine wea...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed-d-11-00114
更新日期:2011-10-01 00:00:00
abstract:AIM:To evaluate magnetic resonance (MR) imaging as a direct-access diagnostic tool for primary care physicians. METHOD:Prospective, case-control study in a Royal Air Force setting. We obtained institutional review board approval and informed consent. Cases consisted of patients with acute knee injury and a physician-o...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.172.4.436
更新日期:2007-04-01 00:00:00
abstract::This case study describes the rehabilitation of 10 active duty U.S. soldiers with exertional rhabdomyolysis. The pathophysiology of rhabdomyolysis is discussed. The initial management is concerned with accurate diagnosis and monitoring of laboratory values to prevent complications. Active and passive range of motion, ...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:This study describes and categorizes the cultural frictions and conflicts within a successfully implemented Internal Medicine Patient-Centered Medical Home (PCMH) clinic at the National Naval Medical Center, and provides lessons learned for combating these concerns. METHODS:A semistructured interview protoco...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed-d-12-00146
更新日期:2013-02-01 00:00:00
abstract:INTRODUCTION:Amputations are increasingly prevalent because of medical complications associated with diabetes, meningitis, peripheral vascular disease, and neoplasms as well as road traffic accidents and war. The use of ultrasound (U/S) to diagnose the cause of pain in the residual limb of amputees is presented togethe...
journal_title:Military medicine
pub_type: 杂志文章,评审
doi:10.7205/MILMED-D-13-00273
更新日期:2013-12-01 00:00:00
abstract:INTRODUCTION:Ibuprofen is commonly used by warfighters in the deployed environment. This study investigated its dose effects on in vitro coagulation in human and pig blood. METHODS:Blood samples were collected from 6 normal volunteers and 6 healthy pigs and processed to make platelet-adjusted samples (100 × 10(3)/μL, ...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-15-00381
更新日期:2016-05-01 00:00:00
abstract::Two cases of pacemaker lead fracture associated with weight-lifting are presented. This is a rare association which has only recently been described in the literature. In both cases, the pacemaker lead was fractured between the clavicle and the first rib, suggesting crush injury. The chest X-ray, pacemaker telemetry w...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::We report on a 22-year-old infantryman who sustained a right frontal wound to his head. He was treated and returned to duty immediately. During a computed tomography scan, 38 years after the incident, a metallic foreign body and disruption of the brain consistent with a projectile track were discovered in his brain. I...
journal_title:Military medicine
pub_type: 杂志文章,评审
doi:10.7205/milmed-d-10-00323
更新日期:2011-02-01 00:00:00
abstract:INTRODUCTION:The purpose of this study is to characterize self-reported protective factors against suicide or self-harm within free-response comments from a harm-risk screening. MATERIALS AND METHODS:Veterans enrolled in Department of Veterans Affairs mental health care were administered a self-harm and suicide screen...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usz111
更新日期:2019-12-01 00:00:00