Abstract：
OBJECTIVES:Depression is more common in Parkinson's disease (PD) than other chronic and disabling disorders. This study aimed to estimate the prevalence and identify potential risk factors influencing depression in 519 consecutive nondemented Chinese PD patients. PATIENTS AND METHODS:Depression was assessed using the Hamilton Rating Scale for Depression (HAMD), PD severity was assessed using Hoehn and Yahr (H&Y) staging, motor symptoms were measured with the Unified PD Rating Scale (UPDRS) part III, and the Non-Motor Symptoms Questionnaire (NMS-Quest) was used to evaluate the global non-motor symptoms (NMS). The PD Sleep Scale (PDSS), and Mini-Mental State Examination (MMSE) were also administered. RESULTS:The mean total HAMD score was 12.60±9.29, and the most prevalent depressive domain was retardation (84.4%). There were significant correlations between the total HAMD score and sex, PD-duration, UPDRS-III, H&Y stage, PD-NMS, PDSS, and MMSE. Non-motor symptoms, poor sleep quality, younger age, and cognitive dysfunction are independent predictors of depression. Among these, non-motor symptoms or sleep disturbances are the most powerful predictors of each depressive domain. We observed a significantly higher total HAMD score and domains of anxiety/somatization, mental disorder, and hopelessness in female patients. However, there was no difference in HAMD total scores and HAMD sub-items between young-onset PD and late-onset PD patients when adjusted by potential confounding factors. CONCLUSIONS:The prevalence rate of depression among nondemented Chinese PD patients is high and similar to those reported in previous studies. The presence of depression in PD patients should be routinely assessed in clinical practice.
journal_name
Clin Neurol Neurosurgjournal_title
Clinical neurology and neurosurgeryauthors
Zhu J,Lu L,Pan Y,Shen B,Xu S,Hou Y,Zhang X,Zhang Ldoi
10.1016/j.clineuro.2017.10.031subject
Has Abstractpub_date
2017-12-01 00:00:00pages
142-148eissn
0303-8467issn
1872-6968pii
S0303-8467(17)30301-3journal_volume
163pub_type
杂志文章abstract：:Single Photon Emission Computed Tomography (SPECT) has been used in the last five years as a method for cerebral bloodflow imaging, especially in cerebral infarction. In this study the first experiences in the Netherlands are presented. In 57.6% of our patients lesions, defined by SPECT were larger than those found by...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/s0303-8467(86)80042-7
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:The natural history of multiple sclerosis (MS) in Brazil has been available in different regions of country. There is no nationwide population-based studies that express general data in Brazil. OBJECTIVE:To review and synthesize available data about MS in Brazil. MATERIAL AND METHODS:Systematic review was ...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.clineuro.2016.07.011
更新日期：2016-12-01 00:00:00
abstract：:The objective of this study was to summarize the available literature describing the presentation, diagnostic evaluation, and management for adults with Type 1 and Type 2 split spinal cord malformations. A review of the literature was performed using the CINAHL, PubMed, Embase, and Web of Science database, alongside a...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.clineuro.2020.105733
更新日期：2020-06-01 00:00:00
abstract：:True and false positive rates of auditory and visual evoked potentials, as well as multi-modal evoked potentials, were assessed in groups of 30 multiple sclerosis patients and 19 healthy age-matched subjects. Sensitivity (true positive rate) generally proved to be high confirming published reports. False positive rate...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/0303-8467(92)90058-b
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:The prognosis of malignant middle cerebral artery infarctions (MCA) is poor. The poor prognosis is attributable to the severe cerebral edema that causes a brain herniation and death. Decompressive surgery reduces mortality and may further improve patient outcomes. However, the safety and effectiv...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2014.04.011
更新日期：2014-07-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2012.06.027
更新日期：2013-05-01 00:00:00
abstract：UNLABELLED:There is evidence to support that oxidative stress is increased in Parkinson's disease (PD) and contributes to degeneration of dopaminergic neurons. Uric acid (UA), a natural antioxidant in blood and brain tissue, scavenging superoxide, peroxynitrite and hydroxyl radical, was found reduced in the serum of PD...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2009.06.012
更新日期：2009-11-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2012.01.007
更新日期：2012-07-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2015.01.007
更新日期：2015-03-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2011.12.033
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVE:We investigated the effectiveness of a right hemispheric surgical approach in treating unruptured anterior communicating artery aneurysms. METHODS:Between January 2005 and June 2012, 305 patients with anterior communicating artery (Acom) aneurysms were treated using the pterional approach. Among them, 113 wh...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2015.06.009
更新日期：2015-10-01 00:00:00
abstract：:Isolated trigeminal neuropathy after cranial trauma is exceptional. A 40-year-old woman was found to have unilateral trigeminal motor paralysis with muscle atrophy, unaccompanied by sensory involvement and without affecting other cranial nerves. She developed this deficit immediately after head trauma. ...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/0303-8467(95)00027-h
更新日期：1995-05-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2008.08.006
更新日期：2009-01-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2016.07.009
更新日期：2016-09-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2013.06.019
更新日期：2013-10-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2007.08.025
更新日期：2008-01-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2012.08.011
更新日期：2013-06-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2008.02.014
更新日期：2008-06-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/0303-8467(83)90073-2
更新日期：1983-01-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2013.12.016
更新日期：2014-03-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/0303-8467(94)90117-1
更新日期：1994-11-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2013.05.017
更新日期：2013-09-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2012.02.045
更新日期：2012-10-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2009.07.004
更新日期：2009-10-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 临床试验,杂志文章
doi：10.1016/s0303-8467(01)00140-8
更新日期：2001-10-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2012.10.007
更新日期：2013-07-01 00:00:00
abstract：:Head trauma may provoke subarachnoid haemorrhage. The question sometimes arises whether in patients with trauma and subarachnoid haemorrhage the latter is of traumatic or aneurysmal origin. We present a 49-year-old patient who fell from a truck, struck his head and was unconscious immediately. On the brain computed to...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/s0303-8467(99)00073-6
更新日期：2000-03-01 00:00:00
abstract：:Colloid cyst of the third ventricle is a known primary brain tumor. The familial occurrence of this cyst and associated conditions has been rarely discussed in the literature. To our knowledge only 10 affected families have been previously reported in the literature. We report the 11th family with this potentially lif...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.clineuro.2007.04.017
更新日期：2007-09-01 00:00:00
abstract：:Ten patients with epilepsy of unknown origin, starting after the age of 50 years, and without clear evidence of cognitive decline were studied with positron emission tomography, using the steady state technique with 15O. Cerebral blood flow and oxygen metabolism were significantly decreased in all cortical areas. No f...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/0303-8467(95)00046-m
更新日期：1995-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the impact of Parkinson's disease (PD) on unpaid, non-professional caregiver (CG) social relationships and related issues, as well as home-help services, over the time-course of the disease. MATERIALS AND METHODS:Cross-sectional telephone survey using a structured questionnaire where CGs were div...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2009.05.011
更新日期：2009-09-01 00:00:00
