Abstract:
PURPOSE:The study aims to detect the polymorphisms in uridine diphosphate glucuronyl transferase (UGT) 2B7∗2 and investigate the corresponding effects on the blood concentrations of valproic acid (VPA) and carbamazepine (CBZ). METHODS:A chemiluminescence immunoassay analyzer was used to detect the plasma concentrations of VPA or CBZ in patients. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to analyze UGT2B7∗2 gene polymorphisms. RESULTS:A total of 117 patients were enrolled under the VPA group, out of which 84 patients were aged 6years or older. Comparison of the blood concentrations of VPA showed significant differences among patients with the three standard genotypes (mutant, heterozygous, and wild-type) based on one-way ANOVA (F=4.386, p=0.016). In addition, comparison of the blood concentrations among the three genotypes in the CBZ group (78 patients) showed no significant differences based on analysis using ANOVA (F=0.897, p=0.412). CONCLUSION:The UGT2B7∗2 gene polymorphisms significantly affect the standard blood concentrations of VPA, but not CBZ.
journal_name
Brain Devjournal_title
Brain & developmentauthors
Zhang H,Zhang W,Li Y,Yan J,Zhang J,Wang Bdoi
10.1016/j.braindev.2017.09.004subject
Has Abstractpub_date
2018-02-01 00:00:00pages
100-106issue
2eissn
0387-7604issn
1872-7131pii
S0387-7604(17)30241-3journal_volume
40pub_type
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