Abstract:
:Two brothers, aged 6 and 4 years, with an unbalanced chromosome translocation (partial trisomy 1), and their mother, a balanced carrier of the translocation, t(1;3)(q42.3;p26.3), were described. Both patients show minor anomalies; a large head with a prominent forehead, low-set and soaring ears, a high-arched palate, a shallow nasal bridge, hypertelorism, and slender hands and feet. The manifestations in our cases were very mild compared to in the previously reported cases of partial trisomy 1. And our patients exhibit psychomotor retardation and ventricular dilatation on brain CT. We speculated that the amount of extra material reflects the phenotype. Our cases and previous reports indicate that the minimum clinical features of partial trisomy 1 are poor psychomotor development, a prominent forehead, and slender hands and feet. And many cases have macrocephaly with ventricular dilatation or hydrocephalus. So these features may be a key for the diagnosis of very mild partial trisomy 1.
journal_name
Brain Devjournal_title
Brain & developmentauthors
Sunaga Y,Ohtsuka T,Nagashima K,Kuroume Tdoi
10.1016/0387-7604(93)90048-dsubject
Has Abstractpub_date
1993-03-01 00:00:00pages
119-24issue
2eissn
0387-7604issn
1872-7131pii
0387-7604(93)90048-Djournal_volume
15pub_type
杂志文章abstract::Molecular background of neurogenetic disease is briefly reviewed. Importance and usefulness of genetic testing are emphasized. Molecular genetics is a powerful tool for investigation of epileptic syndromes. Diagnosis based on gene analysis will give a new insight for pathophysiology and clinical outcome of the patient...
journal_title:Brain & development
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更新日期:2021-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Brain & development
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.braindev.2005.07.003
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journal_title:Brain & development
pub_type: 杂志文章
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(87)80049-9
更新日期:1987-01-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(86)80097-3
更新日期:1986-01-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2018.09.005
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pub_type: 杂志文章
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更新日期:1979-01-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2012.05.010
更新日期:2013-04-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2012.01.009
更新日期:2013-01-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章,评审
doi:10.1016/0387-7604(93)90005-s
更新日期:1993-01-01 00:00:00