Abstract:
BACKGROUND:Published data concerning primary mediastinal sarcomas are limited to small-sized retrospective series. This study reviewed the clinical outcomes of these cases from the SEER (surveillance, epidemiology and end results) database. METHODS:Primary mediastinal sarcomas (1988 - 2013) were assembled from the SEER database. The incidence and 10-year cancer-specific survival rates were compared to other primary mediastinal malignancies (thymic carcinoma, germ cell tumors, neurogenic tumors, Hodgkin / non Hodgkin lymphomas) as well as to non mediastinal sarcomas. RESULTS:A total of 204 patients were recruited into this cohort. Multivariate analysis showed better overall survival for patients with younger age at diagnosis, low grade [hazard ratio 0.427 (95% CI: 0.224-0.814; P= 0.010)], posterior mediastinum location [hazard ratio 0.458 (95% CI: 0.268-0.781; P= 0.004)], node negative disease [hazard ratio 0.463 (95% CI: 0.232-0.923; P= 0.029)] and surgical treatment [hazard ratio 0.488 (95% CI: 0.336-0.709; P <0.0001)]. Compared to other mediastinal malignancies, primary mediastinal sarcomas have the worst 10-year overall survival. Similarly compared to non mediastinal sarcomas, primary mediastinal sarcomas have worse 10-year overall survival (23% versus 55%). CONCLUSION:Primary mediastinal sarcoma is a rare entity with worse prognosis compared to non-mediastinal counterparts. Surgical resection plays a particularly important role in the management.
journal_name
Expert Rev Anticancer Therjournal_title
Expert review of anticancer therapyauthors
Abdel-Rahman Odoi
10.1080/14737140.2017.1378576subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1071-1076issue
11eissn
1473-7140issn
1744-8328journal_volume
17pub_type
杂志文章abstract::The annual conference of the International Society for Biological Therapy of Cancer (iSBTc), recently renamed the Society for Immunotherapy of Cancer (SITC), provides clinicians and scientists with a uniquely broad yet focused view of the growing field of tumor immunology and cancer immunotherapy. In this time of exci...
journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2010-12-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
doi:10.1586/era.13.9
更新日期:2013-03-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2005-08-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 社论
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更新日期:2014-06-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2002-02-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章
doi:10.1586/14737140.2014.947691
更新日期:2014-10-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2008-05-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2007-06-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2007-09-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
doi:10.1586/14737140.2013.837667
更新日期:2013-10-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2003-02-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2010-05-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章
doi:10.1080/14737140.2021.1838279
更新日期:2020-11-02 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2007-02-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,收录出版,评审
doi:10.1586/14737140.9.1.97
更新日期:2009-01-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 社论
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更新日期:2015-03-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Expert review of anticancer therapy
pub_type: 杂志文章,评审
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更新日期:2011-06-01 00:00:00