An update on the recognition and treatment of non-convulsive status epilepticus in the intensive care unit.

abstract：:This discussion will focus on defining the standard of care for neoplastic meningitis, including: What is the role of radiation therapy? What are first-line pharmacotherapeutic agents? Is combination therapy useful? What is the role of corticosteroids? ...

journal_title：Expert review of neurotherapeutics

authors： Recht L,Phuphanich S

更新日期：2004-07-01 00:00:00

abstract：:Recent evidence suggests that active trigger points (TrPs) in neck and shoulder muscles contribute to tension-type headache. Active TrPs within the suboccipital, upper trapezius, sternocleidomastoid, temporalis, superior oblique and lateral rectus muscles have been associated with chronic and episodic tension-type hea...

journal_title：Expert review of neurotherapeutics

authors： Alonso-Blanco C,de-la-Llave-Rincón AI,Fernández-de-las-Peñas C

更新日期：2012-03-01 00:00:00

abstract：:Initial descriptions of bipolar disorder (BD) emphasized that patients returned to a baseline condition after acute episodes. Such definitions were operational in teasing bipolar disorder apart from schizophrenia, where patients were described to be permanently impaired after the initial episodes. However, this view o...

journal_title：Expert review of neurotherapeutics

authors： Kapczinski F,Frey BN,Kauer-Sant'Anna M,Grassi-Oliveira R

更新日期：2008-07-01 00:00:00

abstract：INTRODUCTION:Patients with multiple sclerosis (MS) may suffer from spasticity and pain during their disease course. Baclofen, dantrolene, diazepam and gabapentin have been used as first-line options to treat these conditions, with modest results. Medical use of marijuana smoking has bypassed traditional clinical trials...

journal_title：Expert review of neurotherapeutics

authors： Fragoso YD,Carra A,Macias MA

更新日期：2020-08-01 00:00:00

abstract：:This article proposes a revision of the historical evolution of the concepts of generalized anxiety disorder (GAD). Currently, Darwin's evolutionary theory is the hegemonic paradigm for modern science and influences research on mental disorders. Throughout the 20th Century, the editions of the Diagnostic and Statistic...

journal_title：Expert review of neurotherapeutics

authors： Coutinho FC,Dias GP,do Nascimento Bevilaqua MC,Gardino PF,Pimentel Rangé B,Nardi AE

更新日期：2010-08-01 00:00:00

abstract：:Glucocorticoids exert a variety of immunomodulatory activities. Since changes in glucocorticoid homeostasis impact on susceptibility to autoimmune diseases, and synthetic glucocorticoids are widely used in the treatment of multiple sclerosis, a detailed understanding of their mechanism of action is desirable. Experime...

journal_title：Expert review of neurotherapeutics

authors： Reichardt HM,Gold R,Lühder F

更新日期：2006-11-01 00:00:00

abstract：:With advances in stereotactic and neuroimaging techniques, various minimally invasive image-guided techniques have gained widespread acceptance in the field of neuro-oncology. Laser interstitial thermal therapy (LITT) is an image-guided technique that involves generation of high temperatures using a laser fiber, to ab...

journal_title：Expert review of neurotherapeutics

authors： Sharma M,Balasubramanian S,Silva D,Barnett GH,Mohammadi AM

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Friedreich ataxia (FRDA) is a progressive, inherited, neurodegenerative disease for which there is currently no cure or approved treatment. FRDA is caused by deficits in the production and expression of frataxin, a protein found in the mitochondria that is most likely responsible for regulating iron-sulfur...

journal_title：Expert review of neurotherapeutics

authors： Strawser C,Schadt K,Hauser L,McCormick A,Wells M,Larkindale J,Lin H,Lynch DR

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:The underlying etiology of tension type headache (TTH) is not understood. The current paper highlights the etiologic role of muscle trigger points (TrPs) to the development and maintenance of central sensitization in TTH and its clinical repercussion for proper management of these patients. Areas covered: ...

journal_title：Expert review of neurotherapeutics

authors： Fernández-De-Las-Peñas C,Arendt-Nielsen L

更新日期：2017-09-01 00:00:00

abstract：:Advances in research and better understanding of the pathophysiology of diseases have resulted in an increase in the number of available health interventions that compete for finite public resources. Explicit choices must therefore be made about funding. ...

journal_title：Expert review of neurotherapeutics

authors： Kobelt G

更新日期：2013-12-01 00:00:00

abstract：INTRODUCTION:Chronic inflammatory neuropathies are disorders caused by an immune response to peripheral nerve. They include chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and neuropathy associated with anti-MAG IgM monoclonal gammopathy and other less frequent neurop...

journal_title：Expert review of neurotherapeutics

authors： Nobile-Orazio E,Gallia F,Terenghi F,Bianco M

更新日期：2017-08-01 00:00:00

abstract：:Allosteric mechanisms in receptor heteromers markedly increase the repertoire of receptor recognition and signaling. Of high importance is the altered function in the receptor heteromer versus the receptor homomer. Such a change in receptor function is mainly brought about by agonist induced allosteric receptor-recept...

journal_title：Expert review of neurotherapeutics

authors： Fuxe K,Agnati LF,Borroto-Escuela DO

更新日期：2014-07-01 00:00:00

abstract：:Over the last decade, much progress has been made towards identifying risk factors for schizophrenia. It is now thought that many genes of small effect contribute towards risk of developing schizophrenia and some of these probably confer susceptibility to environmental factors. Large population-based studies, using re...

journal_title：Expert review of neurotherapeutics

authors： Boydell J

更新日期：2001-11-01 00:00:00

abstract：:Alzheimer's disease is the most common form of neurodegenerative dementia and poses considerable health challenges to both patients and their families. Rivastigmine is a powerful slow-reversible, noncompetitive carbamate cholinesterase inhibitor that is approved for the treatment of mild-to-moderate Alzheimer's diseas...

journal_title：Expert review of neurotherapeutics

authors： Desai AK,Grossberg GT

更新日期：2005-09-01 00:00:00

abstract：:Tension-type headache (TTH) is the most prevalent of all headaches and also represents one of the most expensive clinical conditions for the health system. Despite the high impact of this disorder and the existence of well-established diagnostic criteria, knowledge about TTH is still quite limited. In most cases in wh...

journal_title：Expert review of neurotherapeutics

authors： Speciali JG,Eckeli AL,Dach F

更新日期：2008-05-01 00:00:00

abstract：:Cortical spreading depression (CSD) has been at the center stage of migraine pathophysiology for approximately six decades. Reanalysis of CSD reveals several major unbridgeable gaps in this experimental neurophysiologic concept for migraine. Key phenotypic and pharmacological features of migraine challenge the assumed...

journal_title：Expert review of neurotherapeutics

authors： Gupta VK

更新日期：2009-11-01 00:00:00

abstract：:Sumatriptan 85 mg with naproxen sodium 500 mg, a combination tablet for the acute treatment of migraine, is approved in the USA. It is likely that triptan/NSAID combination benefits are a class effect, although the majority of data are on sumatriptan and naproxen sodium. The combination tablet demonstrated superior ef...

journal_title：Expert review of neurotherapeutics

authors： Cleves C,Tepper SJ

更新日期：2008-09-01 00:00:00

abstract：INTRODUCTION:Unique among the different neuropathic pain conditions, trigeminal neuralgia frequently has an excellent response to some selected drugs, which, on the other hand, often entail disabling side effects. Physicians should be therefore acquainted with the management of these drugs and the few alternative optio...

journal_title：Expert review of neurotherapeutics

authors： Di Stefano G,Truini A

更新日期：2017-10-01 00:00:00

abstract：:Background: Triptanophobia is the excessive and inadequately justified concern about potential risks of triptans. We evaluated causes and consequences of nonuse of triptans in chronic migraine (CM) Methods: Case-control study. We included CM patients firstly referred to aheadache unit. Patients were cases or controls ...

journal_title：Expert review of neurotherapeutics

authors： Martínez-Pías E,García-Azorín D,Minguez-Olaondo A,Trigo J,Sierra Á,Ruiz M,Guerrero ÁL

更新日期：2021-01-01 00:00:00

abstract：:Cognitive behavioral therapy has been found to be efficacious in the treatment of generalized anxiety disorder (GAD). However, reviews of the clinical significance has indicated that approximately 50% of patients with GAD return to a 'well' status following treatment. So how might the field advance? One way is to base...

journal_title：Expert review of neurotherapeutics

authors： Heiden Cv

更新日期：2013-02-01 00:00:00

abstract：:Generalized cognitive impairments are stable deficits linked to schizophrenia and key factors associated with functional disability in the disorder. Preclinical data suggest that second-generation antipsychotics could potentially reduce cognitive impairments; however, recent large clinical trials indicate only modest ...

journal_title：Expert review of neurotherapeutics

authors： Hill SK,Bishop JR,Palumbo D,Sweeney JA

更新日期：2010-01-01 00:00:00

abstract：:Alzheimer's disease is an age-related dementia and its incidence is rising in developed countries as the population ages. Amyloid plaques and tau-rich neurofibrillary tangles are pathologic hallmarks of the disease. Treatment is symptomatic, consisting of compounds that block enzymatic acetylcholine degradation (acety...

journal_title：Expert review of neurotherapeutics

authors： Silverberg GD,Mayo M,Saul T,Carvalho J,McGuire D

更新日期：2004-01-01 00:00:00

abstract：:The American Academy of Neurology is an international professional organization of more than 22,000 neurologists and neuroscience professionals. This year the annual meeting was held in Toronto, ON, Canada. A large number of scientific sessions presented numerous advances in the diagnosis, molecular pathogenesis and t...

journal_title：Expert review of neurotherapeutics

authors： Yiu EM,Banwell B

更新日期：2010-08-01 00:00:00

abstract：:Intraoral splints are effective in migraine prevention. In this review, changes in the quality of life of migraineurs treated with a palatal nonoccluding splint were measured. Using the Migraine Specific Quality of Life Instrument (Version 2.1), it was found that the palatal nonoccluding splint significantly improved ...

journal_title：Expert review of neurotherapeutics

authors： Shevel E

更新日期：2005-05-01 00:00:00

abstract：:There is great concern over cardiovascular disease in the schizophrenic population owing to the high incidence of cardiovascular mortality. Increased cardiovascular mortality is related to lifestyle choices (e.g., smoking and sedentary lifestyle) and a high prevalence of comorbid medical conditions, including dyslipid...

journal_title：Expert review of neurotherapeutics

authors： Michelsen JW,Meyer JM

更新日期：2007-07-01 00:00:00

abstract：:Attention-deficit/hyperactivity disorder (ADHD) is a commonly occurring behavioral disorder among children. Community-based physicians are often the primary providers of services for children with ADHD. A set of consensus guidelines has been published by the American Academy of Pediatrics that provides best-practice d...

journal_title：Expert review of neurotherapeutics

authors： Langberg JM,Brinkman WB,Lichtenstein PK,Epstein JN

更新日期：2009-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common CNS disorder occurring worldwide. There is neither proven effective prevention for AD nor a cure for patients with this disorder. Hence, there is an urgent need to develop safer and more efficacious drugs to help combat the tremendous increase in disease progression. The pre...

journal_title：Expert review of neurotherapeutics

authors： Prakash A,Kalra J,Mani V,Ramasamy K,Majeed AB

更新日期：2015-01-01 00:00:00

abstract：:In recent years there has been great scientific and public interest focused on the therapeutic potential of compounds derived from cannabis for the treatment of refractory epilepsy in children. From in vitro and in vivo studies on animal models, cannabidiol (CBD) appears to be a promising anticonvulsant drug with a fa...

journal_title：Expert review of neurotherapeutics

authors： Paolino MC,Ferretti A,Papetti L,Villa MP,Parisi P

更新日期：2016-01-01 00:00:00

abstract：:Evaluation of: Brower KJ, McCammon RJ, Wojnar M, Ilgen MA, Wojnar J, Valenstein M. Prescription sleeping pills, insomnia, and suicidality in the National Comorbidity Survey Replication. J. Clin. Psychiatry DOI: 10.4088/JCP.09m05484gry (2010) (Epub ahead of print). Several studies have investigated the association betw...

journal_title：Expert review of neurotherapeutics

authors： Pae CU,Koh JS,Lee SJ,Han C,Patkar AA,Masand PS

更新日期：2011-03-01 00:00:00

abstract：:Translation of the analgesic efficacy of investigational neurotherapeutics from pre-clinical pain models into clinical trial phases is associated with a high risk of failure. Application of human pain biomarkers in early stages of clinical trials can potentially enhance the rate of successful translation, which would ...

journal_title：Expert review of neurotherapeutics

authors： Arendt-Nielsen L,Nielsen TA,Gazerani P

更新日期：2014-03-01 00:00:00