Fatal Cerebral Edema, Seizures, and Hyponatremia After Trazodone Overdose.

abstract：:The aim of the present study was to evaluate sexual function and behaviour in male patients who take lithium. Participants included 35 bipolar and schizoaffective men, aged 43.3 +/- 9.6 years, who were in euthymic state and were receiving lithium as the sole medical treatment. Eleven patients (31.4%) reported sexual d...

journal_title：Clinical neuropharmacology

authors： Aizenberg D,Sigler M,Zemishlany Z,Weizman A

更新日期：1996-12-01 00:00:00

abstract：:Recent reports suggest some utility for famotidine, a histamine type 2 (H2) antagonist, in the treatment of schizophrenia. The current report describes a treatment-resistant patient with chronic undifferentiated schizophrenia whose most dramatic symptomatic improvements were temporarily related to the open-label addit...

journal_title：Clinical neuropharmacology

authors： Rosse RB,Kendrick K,Tsui LC,Fay-McCarthy M,Collins JP Jr,Rosenberg P,Wyatt RJ,Deutsch SI

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:BL-1020, a novel gamma aminobutyric acid (GABA) ester of perphenazine, is a new oral antipsychotic with a strong affinity for dopamine and serotonin receptors. Unlike first- and second-generation antipsychotics, it has agonist activity at GABA(A). OBJECTIVE:This is the first study to examine tolerability an...

journal_title：Clinical neuropharmacology

authors： Anand R,Geffen Y,Vasile D,Dan I

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Introduction of old and new generations of antipsychotics leads to significant improvements in the positive symptoms of schizophrenia. However, negative symptoms remain refractory to conventional trials of antipsychotic therapy. Recently, there were several open clinical human trials with curcumin. Curcumin ...

journal_title：Clinical neuropharmacology

authors： Miodownik C,Lerner V,Kudkaeva N,Lerner PP,Pashinian A,Bersudsky Y,Eliyahu R,Kreinin A,Bergman J

更新日期：2019-07-01 00:00:00

abstract：:Sargramostim (GM-CSF) therapy was instituted in a 49-year-old woman with hepatitis C on chronic interferon alpha-2b therapy. Within two weeks, she developed progressive confusion, lethargy, and gait disturbance. At autopsy 4 months later, diffuse perivascular nonmonoclonal lymphoid infiltrates were demonstrated throug...

journal_title：Clinical neuropharmacology

authors： Riggs JE,Mansmann PT,Cook LL,Schochet SS Jr,Hogg JP

更新日期：1999-09-01 00:00:00

abstract：:The purpose of this paper is to add to the growing number of reports about kleptomania occurring in relation to brain injury as well as to present the authors' findings regarding treatment strategies. The authors present two case reports of patients who developed the new onset of kleptomania after closed head trauma. ...

journal_title：Clinical neuropharmacology

authors： Aizer A,Lowengrub K,Dannon PN

更新日期：2004-09-01 00:00:00

abstract：:One hundred patients with Parkinson's disease (PD) and five patients with progressive supranuclear palsy were questioned about the frequency, circumstances, and consequences of falling. Parkinsonian symptoms were scored using the unified rating scale. Thirty-eight percent of parkinsonian patients fell, and 13% fell mo...

journal_title：Clinical neuropharmacology

authors： Koller WC,Glatt S,Vetere-Overfield B,Hassanein R

更新日期：1989-04-01 00:00:00

abstract：:Over the last several years, the therapeutic approach to bacterial meningitis has been changing. The neurological complications of bacterial meningitis result from an inflammatory process that is initiated by the lysis of bacteria in the subarachnoid space by antibiotics; to alter the pathophysiologic events initiated...

journal_title：Clinical neuropharmacology

authors： Roos KL

更新日期：1993-10-01 00:00:00

abstract：:Male albino rats received a stereotaxic injection of 6-hydroxydopamine (6-OHDA) into the right substantia nigra. Animals demonstrating contralateral rotations 2 weeks postoperatively with apomorphine (0.5 mg/kg i.p.) were treated with L-Dopa (55 mg/kg i.p.), bromocriptine (2 mg/kg i.p.), or polyethylene glycol (vehicl...

journal_title：Clinical neuropharmacology

authors： Schneider MB,Murrin LC,Pfeiffer RF,Deupree JD

更新日期：1984-01-01 00:00:00

abstract：:In this report, we present a patient whose positive symptoms did not improve despite being treated with clozapine monotherapy at a therapeutic dose for 4 months, and whose symptoms began to resolve after aripiprazole long-acting injection adjunction to clozapine. A 22-year-old man was diagnosed as having schizophrenia...

journal_title：Clinical neuropharmacology

authors： Balcioglu YH,Gokcay H,Yesilkaya UH

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Perampanel is a recently introduced antiepileptic drug (AED) with a unique action mechanism of noncompetitive and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist. Because of delayed approval of perampanel in most Asian countries, there is limited information on the clinical usefulne...

journal_title：Clinical neuropharmacology

authors： Kim DW,Oh J

更新日期：2018-01-01 00:00:00

abstract：:Preclamol, the (-)enantiomer of 3-PPP (= 3(3-hydroxyphenyl)-N-n-propyl piperidine), has a selective dopamine autoreceptor- and postsynaptic mixed agonist-antagonist profile. Its action on patients with disabling on-off parkinsonian fluctuations has been studied and compared with those of placebo and subcutaneous apomo...

journal_title：Clinical neuropharmacology

authors： Pirtosek Z,Merello M,Carlsson A,Stern G

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVES:Autism spectrum disorders (ASDs) have core impairments in social communication as well as the presence of repetitive, stereotypic behaviors and restricted interests. Older adolescents and young adults are particularly impacted by these deficits. Preclinical data implicate glutamatergic dysfunction in the pat...

journal_title：Clinical neuropharmacology

authors： Urbano M,Okwara L,Manser P,Hartmann K,Herndon A,Deutsch SI

更新日期：2014-05-01 00:00:00

abstract：:A 56 year-old woman who suffered from parkinsonism, oro-lingual dyskinesia (OLD) and tardive akathisia (TA) due to sulpiride is reported. OLD and TA appeared after sulpiride withdrawal. The patient was successfully treated with tetrabenazine even a mild parkinsonism was present. TA seems to be related with an apparent...

journal_title：Clinical neuropharmacology

authors： López de Munain A,Poza JJ,Gorospe A,Arce A,Martí Massó JF

更新日期：1994-10-01 00:00:00

abstract：:Age-associated memory impairment (AAMI) is a diagnostic term applied to healthy persons greater than 50 years of age who have experienced a gradual decline in memory that lies within the boundaries of normality. Although the behavioral deficits associated with AAMI are modest in comparison to those associated with dem...

journal_title：Clinical neuropharmacology

authors： Crook TH,Larrabee GJ,Youngjohn JR

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Catatonia is a severe condition in patients. Electroconvulsive treatment or medication with benzodiazepines and/or antipsychotics are regarded as standard treatment. CASE PRESENTATION:We report a case of a patient with catatonic features in whom electroconvulsive treatment and benzodiazepine and/or antipsyc...

journal_title：Clinical neuropharmacology

authors： Sato Y,Shinozaki M,Okayasu H,Yasui-Furukori N,Shimoda K

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:Persistent sequelae of lithium intoxication gained clinical attention in the 1980s and were named Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT). The authors review the published cases of SILENT reported in the literature and discuss various clinical manifestations. METHODS:The authors'...

journal_title：Clinical neuropharmacology

authors： Adityanjee,Munshi KR,Thampy A

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To determine if levetiracetam is efficacious in the treatment of essential tremor. METHODS:Fifteen patients (3 women), aged 35 to 83 years, with essential tremor were studied in a double-blind, placebo-controlled crossover trial of levetiracetam. During the 2 treatment periods, levetiracetam or placebo was t...

journal_title：Clinical neuropharmacology

authors： Elble RJ,Lyons KE,Pahwa R

更新日期：2007-11-01 00:00:00

abstract：:Few studies have been published on the pharmacologic response to treatment of patients whose seizures begin after 40 years of age. The purpose of this study was to assess the impact of chronic pharmacotherapy on the seizure control of such patients. We retrospectively studied the seizure frequency recorded during a 12...

journal_title：Clinical neuropharmacology

authors： Hasegawa H,Kanner AM

更新日期：1995-02-01 00:00:00

abstract：:Monoamine oxidase (MAO) inhibitors (MAOIs) provide effective alternative therapy for those patients with major depression who do not respond to tricyclic antidepressants or such related compounds as the selective serotonin reuptake inhibitors. This article reviews studies on the efficacy of both the classical MAOIs an...

journal_title：Clinical neuropharmacology

authors： Nolen WA,Hoencamp E,Bouvy PF,Haffmans PM

更新日期：1993-01-01 00:00:00

abstract：:Oxidant stress resulting from excess dopamine (DA) may contribute to the development and progression of Parkinson's disease (PD). Free radicals resulting from the enzymatic metabolism of DA are most often discussed in this regard. However, levodopa (L-DOPA) and DA can also undergo autooxidation, producing free radical...

journal_title：Clinical neuropharmacology

authors： Ling ZD,Pieri SC,Carvey PM

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVES:Aripiprazole and ziprasidone are 2 antipsychotic medications that are relatively devoid of the metabolic adverse effects associated with the second-generation antipsychotics. This study aimed to evaluate the effectiveness of switching to ziprasidone in patients who had insufficient response or intolerance to...

journal_title：Clinical neuropharmacology

authors： Kim SW,Shin IS,Kim JM,Bae KY,Yang SJ,Yoon JS

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Neuroleptic malignant syndrome was induced by aripiprazole in a 12 1/2-year-old boy. The patient had a history of reactive airway disease, pervasive developmental disorder, and learning disability. METHOD:The patient was interviewed and examined, and additional history was taken from the medical records. The...

journal_title：Clinical neuropharmacology

authors： Palakurthi HB,Parvin MM,Kaplan S

更新日期：2007-01-01 00:00:00

abstract：:Prion diseases are invariably fatal. Recently, quinacrine and chlorpromazine have been suggested as immediate candidates for the treatment of Creutzfeldt-Jakob disease and other prion diseases. The objective of this paper was to report on 2 fatal familial insomnia patients whose overall condition worsened despite quin...

journal_title：Clinical neuropharmacology

authors： Benito-León J

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:To describe an unusual case of camptocormia responding to levodopa. METHODS:We present a case of camptocormia with a sustained excellent response to levodopa in a patient with negative dopamine transporter and no DYT 5 genetic mutations. RESULTS:We present a 52-year-old man with 2 years' history of progress...

journal_title：Clinical neuropharmacology

authors： Oravivattanakul S,Abboud H,Fernandez H,Itin I

更新日期：2014-03-01 00:00:00

abstract：:The objective of this study was to evaluate the safety, tolerability, maximum tolerated dose, pharmacokinetics, and pharmacodynamics of five fixed doses of ganstigmine (CHF 2819) in patients with probable Alzheimer's disease (AD). This randomized, double-blind, placebo-controlled trial evaluated five dose levels (5, 7...

journal_title：Clinical neuropharmacology

authors： Jhee SS,Fabbri L,Piccinno A,Monici P,Moran S,Zarotsky V,Tan EY,Frackiewicz EJ,Shiovitz T

更新日期：2003-05-01 00:00:00

abstract：:In order to have a correct evaluation of the activity of a nootropic drug, the criteria adopted for the choice of patients to be included in the clinical trials and the methods used to clarify the meaning of changes observed on cognitive tasks are reported. The results of a clinical trial with the nootropic oxiracetam...

journal_title：Clinical neuropharmacology

authors： Gainotti G,Benedetti N,Caltagirone C,Nocentini U

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:To assess quantitatively the influence of rotigotine transdermal patch on daytime sleepiness, the most common adverse event by non-ergot dopamine agonists (DAs), in Parkinson disease (PD) patients. METHODS:An open-label study enrolled PD patients with unsatisfactory control of motor symptoms. Treatment with...

journal_title：Clinical neuropharmacology

authors： Ohta K,Osada T

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:There has been an increase in the European and North American schizophrenia literature discussing the high prevalence of metabolic syndrome induced by atypical antipsychotic agents. The aim of this article was to review available data on metabolic syndrome induced by atypical antipsychotic agents in patients ...

journal_title：Clinical neuropharmacology

authors： Bou Khalil R

更新日期：2012-05-01 00:00:00

abstract：:This study was devised to check the feasibility and validity of a rating scale specifically designed to evaluate gait impairment in Parkinson's disease (RSGE). Demographic data, a brief questionnaire on general aspects influencing gait and mobility, a battery of scales (Barthel Index; Hoehn and Yahr staging; and North...

journal_title：Clinical neuropharmacology

authors： Martínez-Martín P,García Urra D,del Ser Quijano T,Balseiro Gómez J,Gómez Utrero E,Piñeiro R,Andrés MT

更新日期：1997-06-01 00:00:00