Abstract:
OBJECTIVE:To determine if levetiracetam is efficacious in the treatment of essential tremor. METHODS:Fifteen patients (3 women), aged 35 to 83 years, with essential tremor were studied in a double-blind, placebo-controlled crossover trial of levetiracetam. During the 2 treatment periods, levetiracetam or placebo was titrated from 500 to 3000 mg/d during a 5-week titration phase, as tolerated, and the maximum tolerated dosage was then maintained for 4 weeks. There was a 3-week washout phase between the 2 treatment periods. Patients were assessed with the Fahn-Tolosa-Marín tremor rating scale (TRS), and tremor in the spiral and line drawings of 7 patients was quantified with a computerized digitizing tablet. Changes in other antitremor medications (10 patients) were not permitted during the study. RESULTS:The planned enrollment of 45 patients was stopped when an interim analysis of the first 15 patients revealed no efficacy. One patient failed to achieve the 3000-mg/d dosage of levetiracetam. Three patients dropped out of the study due to lack of efficacy and other side effects. The analysis of TRS data with these three patients excluded and after imputing their missing data (last value carried forward) revealed a statistically insignificant trend for all TRS and tablet measures to be worse when patients were taking levetiracetam. There was no period effect or treatment-period interaction for any measure of tremor. The results were the same for the 5 patients taking no other antitremor medications. CONCLUSIONS:Levetiracetam is not beneficial in the treatment of essential tremor.
journal_name
Clin Neuropharmacoljournal_title
Clinical neuropharmacologyauthors
Elble RJ,Lyons KE,Pahwa Rdoi
10.1097/WNF.0b013E31807A32C6subject
Has Abstractpub_date
2007-11-01 00:00:00pages
350-6issue
6eissn
0362-5664issn
1537-162Xpii
00002826-200711000-00005journal_volume
30pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract::We investigated genetic polymorphism of the cytochrome P-450 CYP2D6 gene from white patients with idiopathic Parkinson's disease (IPD). The mutations of the CYP2D6 gene associated with the poor metabolizer (PM) phenotype of the debrisoquine/sparteine polymorphism were analyzed in DNA of 130 IPD patients by a polymeras...
journal_title:Clinical neuropharmacology
pub_type: 杂志文章
doi:10.1097/00002826-199619030-00003
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abstract::Studies assessing the effect of transdermal nicotine in Parkinson's disease (PD) have generated mixed results regarding its efficacy to treat motor and cognitive deficits. These studies generally reported good tolerability in nonsmoking PD patients. The authors report the tolerability data of an open trial with transd...
journal_title:Clinical neuropharmacology
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doi:10.1097/00002826-200309000-00004
更新日期:2003-09-01 00:00:00
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章
doi:
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abstract::The effect of arotinolol, a peripherally acting beta-adrenergic-blocking agent, on postural or kinetic tremor was studied in monkeys with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Male cynomolgus monkeys (Macaca fascicularis) were treated with three injections of MPTP hydrochloride (0.3...
journal_title:Clinical neuropharmacology
pub_type: 杂志文章
doi:10.1097/00002826-199210000-00005
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journal_title:Clinical neuropharmacology
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVES:Treatment-resistant depression is a common occurrence in clinical practice as well as combination treatment with 2 different antidepressants. In the present case series, we study the effectiveness of the addition of reboxetine, during 12 weeks, to 14 outpatients diagnosed with major depressive disorder, acco...
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doi:10.1097/01.WNF.0000228211.19818.14
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doi:10.1097/WNF.0b013e31811510ed
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journal_title:Clinical neuropharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/WNF.0b013e3181c46f48
更新日期:2010-01-01 00:00:00
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journal_title:Clinical neuropharmacology
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doi:10.1097/00002826-199108000-00005
更新日期:1991-08-01 00:00:00
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章
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更新日期:1992-12-01 00:00:00
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更新日期:2012-09-01 00:00:00
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章
doi:10.1097/00002826-199008000-00002
更新日期:1990-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1097/WNF.0000000000000188
更新日期:2016-11-01 00:00:00
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章,评审
doi:
更新日期:1999-11-01 00:00:00
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/WNF.0b013e31827db49b
更新日期:2013-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
pub_type: 临床试验,杂志文章
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更新日期:2010-05-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-07-01 00:00:00
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2009-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2009-07-01 00:00:00
abstract::Levodopa is the most effective drug for symptomatic control of Parkinson syndrome (PS). We report a 22-year clinicopathological study of 59 PS cases. Of the entire group, 37 (63%) had an adequate trial on levodopa. Some improvement was noted on that drug in 24 (65%) cases. Improvement was seen in 94% of idiopathic Par...
journal_title:Clinical neuropharmacology
pub_type: 杂志文章
doi:10.1097/00002826-199012000-00007
更新日期:1990-12-01 00:00:00
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journal_title:Clinical neuropharmacology
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更新日期:2002-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章
doi:10.1097/WNF.0B013E3181634EA6
更新日期:2009-01-01 00:00:00
abstract::Fifty-six chronic schizophrenic patients were randomized into haloperidol decanoate (HD) or placebo groups for 48 weeks of double-blind treatment. The double-blind trial was preceded by a 15-week single-blind run-in period, during which all patients were treated with 60 mg of HD (approximately corresponding to 3.6 mg ...
journal_title:Clinical neuropharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1991-01-01 00:00:00
abstract::This study was devised to check the feasibility and validity of a rating scale specifically designed to evaluate gait impairment in Parkinson's disease (RSGE). Demographic data, a brief questionnaire on general aspects influencing gait and mobility, a battery of scales (Barthel Index; Hoehn and Yahr staging; and North...
journal_title:Clinical neuropharmacology
pub_type: 杂志文章,多中心研究
doi:10.1097/00002826-199706000-00001
更新日期:1997-06-01 00:00:00
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章
doi:10.1097/00002826-198412000-00018
更新日期:1984-01-01 00:00:00