Abstract:
OBJECTIVES:To assess quantitatively the influence of rotigotine transdermal patch on daytime sleepiness, the most common adverse event by non-ergot dopamine agonists (DAs), in Parkinson disease (PD) patients. METHODS:An open-label study enrolled PD patients with unsatisfactory control of motor symptoms. Treatment with rotigotine transdermal patch was titrated to optimal dose (4-8 mg/24 hours) over 2 to 4 weeks. Primary outcome was Epworth Sleepiness Scale (ESS) for daytime sleepiness. Secondary outcomes included Hoehn&Yahr stage, time spent with dyskinesia, Clinical Global Impression of Improvement (CGI-I) of motor symptoms, adverse events, and compliance. RESULTS:The subjects were 31 PD patients (age 72 ± 8, Hoehn &Yahr stage 2.7 ± 0.9, mean ± SD). The ESS did not increase after rotigotine treatment (7.2 ± 4.9 before treatment, 6.2 ± 4.0 with 4 mg/24 hour, and 8.1 ± 6.4 with 8 mg/24 hour). The CGI-I score improved after treatment; responder rate reached 88.9% with 8 mg/24 hours. No patients showed worsening in other secondary outcomes. In 13 patients treated with equivalent doses of rotigotine switched from other DAs (pramipexole, ropinirole, and cabergoline), ESS did not increase after treatment (10.0 ± 4.6 before and 8.6 ± 4.5 after treatment) and decreased without worsening of CGI-I in 54% patients. Other secondary outcomes did not worsen after treatment. CONCLUSIONS:Twenty four-hour transdermal delivery of rotigotine at doses up to 8 mg/24 hours does not worsen the daytime sleepiness in PD patients and often improves it when switched from other non-ergot DAs. This is achieved together with satisfactory improvement in motor symptoms, demonstrating that this new modality of non-ergot DA is well tolerated and beneficial in PD patients.
journal_name
Clin Neuropharmacoljournal_title
Clinical neuropharmacologyauthors
Ohta K,Osada Tdoi
10.1097/WNF.0000000000000110subject
Has Abstractpub_date
2015-11-01 00:00:00pages
231-5issue
6eissn
0362-5664issn
1537-162Xjournal_volume
38pub_type
杂志文章abstract::Over the last several years, the therapeutic approach to bacterial meningitis has been changing. The neurological complications of bacterial meningitis result from an inflammatory process that is initiated by the lysis of bacteria in the subarachnoid space by antibiotics; to alter the pathophysiologic events initiated...
journal_title:Clinical neuropharmacology
pub_type: 杂志文章,评审
doi:10.1097/00002826-199310000-00001
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abstract:BACKGROUND:Topiramate (TPM) is a fructose derivative, which was originally developed as an antiepileptic. In this context, movement disorders (MDs) are possible adverse events secondary to TPM. CASE REPORTS:Two patients (cases 1 and 2) developed myoclonus, and the other 2 had restless leg syndrome (RLS, cases 3 and 4)...
journal_title:Clinical neuropharmacology
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doi:10.1097/WNF.0000000000000395
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章
doi:10.1097/00002826-199304000-00005
更新日期:1993-04-01 00:00:00
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
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doi:
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Clinical neuropharmacology
pub_type: 临床试验,杂志文章,评审
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
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