Abstract:
OBJECTIVES:To assess quantitatively the influence of rotigotine transdermal patch on daytime sleepiness, the most common adverse event by non-ergot dopamine agonists (DAs), in Parkinson disease (PD) patients. METHODS:An open-label study enrolled PD patients with unsatisfactory control of motor symptoms. Treatment with rotigotine transdermal patch was titrated to optimal dose (4-8 mg/24 hours) over 2 to 4 weeks. Primary outcome was Epworth Sleepiness Scale (ESS) for daytime sleepiness. Secondary outcomes included Hoehn&Yahr stage, time spent with dyskinesia, Clinical Global Impression of Improvement (CGI-I) of motor symptoms, adverse events, and compliance. RESULTS:The subjects were 31 PD patients (age 72 ± 8, Hoehn &Yahr stage 2.7 ± 0.9, mean ± SD). The ESS did not increase after rotigotine treatment (7.2 ± 4.9 before treatment, 6.2 ± 4.0 with 4 mg/24 hour, and 8.1 ± 6.4 with 8 mg/24 hour). The CGI-I score improved after treatment; responder rate reached 88.9% with 8 mg/24 hours. No patients showed worsening in other secondary outcomes. In 13 patients treated with equivalent doses of rotigotine switched from other DAs (pramipexole, ropinirole, and cabergoline), ESS did not increase after treatment (10.0 ± 4.6 before and 8.6 ± 4.5 after treatment) and decreased without worsening of CGI-I in 54% patients. Other secondary outcomes did not worsen after treatment. CONCLUSIONS:Twenty four-hour transdermal delivery of rotigotine at doses up to 8 mg/24 hours does not worsen the daytime sleepiness in PD patients and often improves it when switched from other non-ergot DAs. This is achieved together with satisfactory improvement in motor symptoms, demonstrating that this new modality of non-ergot DA is well tolerated and beneficial in PD patients.
journal_name
Clin Neuropharmacoljournal_title
Clinical neuropharmacologyauthors
Ohta K,Osada Tdoi
10.1097/WNF.0000000000000110subject
Has Abstractpub_date
2015-11-01 00:00:00pages
231-5issue
6eissn
0362-5664issn
1537-162Xjournal_volume
38pub_type
杂志文章abstract::The effects of 5-HT are varied and widely distributed throughout the human body. At this time, 5-HT research is a field ripe for "plucking." Not only is there a great demand for more selective agonists and antagonists, but there is more than enough work needed in receptor binding studies to keep pharmacologists employ...
journal_title:Clinical neuropharmacology
pub_type: 杂志文章,评审
doi:
更新日期:1991-02-01 00:00:00
abstract::Despite ongoing dispute over the pathophysiologic basis of migraine, the vasospastic theory of pathogenesis has brought to the forefront a promising class of new antimigraine agents, the Ca2+ channel antagonists. Voltage-dependent Ca2+ channels, integral membrane proteins that permit extracellular Ca2+ to enter cells ...
journal_title:Clinical neuropharmacology
pub_type: 杂志文章,评审
doi:10.1097/00002826-198608000-00001
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章
doi:10.1097/00002826-200311000-00009
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章
doi:10.1097/WNF.0b013e318205070b
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pub_type: 杂志文章,评审
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journal_title:Clinical neuropharmacology
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doi:10.1097/00002826-200203000-00011
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
pub_type: 临床试验,杂志文章,评审
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更新日期:1989-01-01 00:00:00
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
pub_type: 临床试验,杂志文章
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章
doi:10.1097/00002826-198412000-00018
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章
doi:10.1097/WNF.0000000000000411
更新日期:2020-11-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2004-01-01 00:00:00
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更新日期:2017-01-01 00:00:00
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更新日期:2003-03-01 00:00:00
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章,评审
doi:10.1097/00002826-199013003-00009
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
pub_type: 临床试验,杂志文章
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journal_title:Clinical neuropharmacology
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Clinical neuropharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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