Abstract：
BACKGROUND:Except for glucocorticoids there is a lack of neuroprotective medication in neurosurgical interventions. OBJECTIVE:An overview of clinical trials investigating administration of the calcium antagonist nimodipine and hydroxyethyl starch (HES) in vestibular schwannoma (VS) surgery is given. Basic research is addressed and potential neuroprotective effect mechanisms are discussed, as are perspectives for application of the concept to other types of surgery with a risk postoperative impairment of nerve function. MATERIALS AND METHODS:A selective PubMed search was performed and all 10 clinical trials corresponding to the search criteria were included. RESULTS:Four trials with an intraoperative start of the medication showed a positive effect for the preservation of facial nerve function and hearing preservation. A pilot study showed superiority of prophylactic treatment over intraoperative application. There were no significant results in a prospective multicenter phase III trial. After 1 year, postoperative facial nerve preservation rates were excellent in both groups. However, the risk of hearing loss was twice as high in the control group. A combined analysis of the phase III trial with its pilot study showed significant results for better hearing preservation rates in the treatment group (probably by increasing the case load). CONCLUSION:Prophylactic nimodipine can be recommended in VS surgery in patients with good preoperative hearing. The effect mechanisms of nimodipine and modifications to prophylaxis should be clarified in basic research.
journal_name
HNOjournal_title
HNOauthors
Scheller C,Herzfeld E,Strauss Cdoi
10.1007/s00106-017-0386-0subject
Has Abstractpub_date
2017-09-01 00:00:00pages
714-718issue
9eissn
0017-6192issn
1433-0458pii
10.1007/s00106-017-0386-0journal_volume
65pub_type
杂志文章,评审相关文献
HNO文献大全abstract：:Classical prognostic factors for squamous cell carcinoma of the head and neck (HNSCC) are based on general parameters such as tumor stage or histological grading and only allow for a rough estimation of the clinical course. However, predicting individual responses to treatment remains challenging and diverging clinica...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s00106-010-2108-8
更新日期：2010-07-01 00:00:00
abstract：:Air bags are among the latest developments in extensive automobile safety systems. They successfully have saved the lives of car occupants in road accidents. Many additional injuries caused by air bags from minor to severe have been reported. With the help of two acceleration sensors, the electronic tuner amplifier re...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s001060050657
更新日期：2000-10-01 00:00:00
abstract：:A microphone constructed for implantation in the posterior wall of the auditory canal and a piezoelectric transducer serving as the main components of an implantable hearing aid were temporally implanted in five patients during middle ear surgery under local anesthesia. The microphone was positioned beneath the skin o...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s001060050166
更新日期：1997-10-01 00:00:00
abstract：:In this study we developed another method for the detection of nasopharyngeal closing patterns. This investigation of dynamic closure patterns was based on flexible video-nasopharyngoscopy and was undertaken in both healthy subjects and patients with dysarthria. Quantitative assessments of pharyngeal wall excursions a...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s001060050124
更新日期：1997-06-01 00:00:00
abstract：:The megadolichobasilar artery is a rare vascular anomaly that can cause a variety of clinical symptoms but is usually asymptomatic. Not much attention has been given as yet to a possible sensorineural hearing loss caused by a megadolichobasilar anomaly. Vascular compression of the vestibulocochlear nerve must be assum...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s001060050411
更新日期：1999-05-01 00:00:00
abstract：:Fifty-one patients with inverted papillomas of the nose and paranasal sinuses underwent surgery, 35 by an intranasal endoscopic method and 16 by an extranasal approach. The recurrence rate after endoscopy surgery was 17% (6/35), compared with 19% (3/16) after an external approach. Endoscopic surgery proved to be succe...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:Deflection of the hair bundle of isolated outer hair cells from the guinea pig cochlea can induce a receptor potential. Outer hair cells from the third and fourth turns of the guinea pig cochlea were isolated according to the method described by Zenner et al. Cells were maintained in Hank's balanced salt solution at r...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:Extrapolated DPOAE growth functions can be applied in ENT diagnostics for a specific assessment of cochlear dysfunction. In screening newborn hearing, they are able to detect transitory sound conductive hearing loss and thus help to reduce the rate of false positive TEOAE responses in the early postnatal period. Since...
journal_title：HNO
pub_type： 杂志文章,评审
doi：10.1007/s00106-004-1179-9
更新日期：2005-02-01 00:00:00
abstract：:Since 1973, 307 patients have been treated for Reinke's oedema in the ENT Department of the University of Marburg. A retrospective study from 1983 and observations up to 1989 investigated the aetiology and the prognosis of the disease. Two aetiological factors were found: smoking and voice abuse. Surgical treatment, s...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:Pathological auditory brainstem responses (lack of responses, elevated thresholds and perturbed waveforms) in combination with present otoacoustic emissions are typical audiometric findings in patients with a hearing impairment that particularly affects speech comprehension or complete deafness. This heterogenous grou...
journal_title：HNO
pub_type： 杂志文章,评审
doi：10.1007/s00106-006-1450-3
更新日期：2006-11-01 00:00:00
abstract：:To investigate the dynamic properties of human hearing, experiments in vivo and with cadaver specimens can be carried out. Furthermore, electrical or mechanical models can also be used to study specific phenomena and parameter sensitivities. Present electrical and mechanical models are often based on crude structural ...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND:Girls tend to acquire language skills faster than boys do. Furthermore, specific language impairment and dyslexia are diagnosed more often in males than in females. We investigated whether auditory verbal learning skills in boys are inferior to those of girls as a possible cause for gender dependency in lang...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s00106-009-1996-y
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:First line antibiotic treatment of uncomplicated acute otitis media has been questioned. PATIENTS AND METHODS:In an prospective, open, controlled study, 390 children aged 1-10 years were treated either conventionally (free combinations of decongestant nose drops, mucolytics, analgesics and antibiotics) or a...
journal_title：HNO
pub_type： 临床试验,杂志文章
doi：10.1007/s00106-004-1185-y
更新日期：2005-08-01 00:00:00
abstract：:The Chordoma is a fully malignant tumor deriving from remnants of the chorda dorsalis. In ENT it mainly appears as nasopharyngeal or parapharyngeal mass, growing slowly and only very late giving rise to severe symptoms by invading the skull base and the vertebra, thus making an effective treatment sometimes almost imp...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:Local drug application to the inner ear offers a number of advantages over systemic delivery. Local drug therapy currently encompasses extracochlear administration (intratympanic injection); intracochlear administration, particularly for gene and stem cell therapy; as well as various combinations with auditory neurose...
journal_title：HNO
pub_type： 杂志文章,评审
doi：10.1007/s00106-016-0257-0
更新日期：2016-11-01 00:00:00
abstract：:The non-surgical treatment of vestibular disorders must be based on current knowledge of vestibular pathophysiology. It is generally accepted that after vestibular lesions a self-repair mechanism exists that allows a more or less complete recovery. In cases of persisting vestibular complaints the physician's duty cons...
journal_title：HNO
pub_type： 杂志文章,评审
doi：
更新日期：1993-05-01 00:00:00
abstract：:The conservative treatment of idiopathic sudden deafness generally shows good results. There are, however, some cases resistant to therapy which may be treated surgically by vestibulotomy. Reports are made on personal experiences as well as those of other authors. Vestibulotomy is recommended for those patients in who...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1975-03-01 00:00:00
abstract：BACKGROUND:Cleft lip and palate are the most common malformation in the orofacial region. The type and dimension of the cleft determine the functional limitations of respiration, swallowing, speech, articulation and hearing. In addition, cosmetic and communicative restrictions influence the cognitive, social and educat...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s00106-003-0843-9
更新日期：2003-06-01 00:00:00
abstract：:Three patients with complete sudden unilateral hearing loss suffered from delayed vertigo and presented a strong geotropic positional nystagmus during the evolution of their disease. Significant direction-fixed spontaneous nystagmus was absent, although two of the three patients had markedly decreased caloric response...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1990-02-01 00:00:00
abstract：BACKGROUND:We examined whether training conceptualized as a complement to standard medical treatment (ST) for acute tinnitus to promote patients' capacity to distract attention from their tinnitus and to relax (distraction and relaxation training) has a positive effect on tinnitus-specific distress (tinnitus loudness, ...
journal_title：HNO
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00106-009-2019-8
更新日期：2010-05-01 00:00:00
abstract：:Extensive tracheal defects after prolonged assisted ventilation, trauma or large resections in tumor surgery are a challenge in plastic and reconstructive surgery. Defects which cannot be satisfactorily repaired reguine near of an alloplastic tracheal replacement. Previous experimental and clinical experiences in the ...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：:Due to the frequency of this phenomenon and the often considerable distress caused to the affected person, competent advice, diagnosis and treatment of snoring in adults is of particular importance. The aim of this guideline is to promote high-quality medical care for patients affected by this problem. According to th...
journal_title：HNO
pub_type： 杂志文章,实务指引
doi：10.1007/s00106-010-2103-0
更新日期：2010-03-01 00:00:00
abstract：:Transtympanic electrocochleography (ECoG) enables auditory evoked potentials to be recorded directly from the peripheral organ, and ECoG recordings can be used as a routine during operations. Examples of cochlear and eighth nerve monitoring in middle ear, inner ear, and cerebellopontine angle surgery are given. This m...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:In order to overcome the disadvantages of hearing aids, a significant amount of research aimed at replacing them by implanted ossicular-coupled electronic hearing devices is being carried out. The technical and audiological demands on the electromechanical transducer of an implantable hearing aid for moderate to sever...
journal_title：HNO
pub_type： 杂志文章,评审
doi：10.1007/s001060050156
更新日期：1997-10-01 00:00:00
abstract：:An unusually long uvula as a cause of chronic throat irritation with the sensation of a foreign body in a 35-year old patient is reported, with symptoms relieved by partial resection of the uvula. ...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Immediate operative reposition of traumatic eardrum perforations has been found to give better morphological results when compared with spontaneous healing. The operative technique and results of healing in 32 patients treated at the ENT Department, University Hospital, Zürich, are discussed. ...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1979-04-01 00:00:00
abstract：:Only a few psychological papers deal with functional dysphonia. Even fewer empirical studies are concerned with the importance of variations in personality and neurotic behavioural patterns that are typical of functional dysphonia. The enumeration of other functional disorders is important. We suggest that difficultie...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1987-06-01 00:00:00
abstract：:Guinea pig cochleae were prepared for scanning electron microscopy (SEM). The lateral surface of the outer hair cells was studied first with secondary electrons. It was possible to find a network of tubular cisterns and long mitochondria stained by osmium immediately under the plasma membrane detected by backscattered...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1988-03-01 00:00:00
abstract：BACKGROUND:The excision of sentinel lymph nodes has a growing relevance in the diagnosis of oral and oropharyngeal cancer in cases of N0 necks. The validity of sentinel node biopsy (SNB) was examined as a single surgical staging tool. PATIENTS AND METHODS:Within the framework of a multi-modal treatment scheme, SNB wit...
journal_title：HNO
pub_type： 临床试验,杂志文章
doi：10.1007/s00106-004-1191-0
更新日期：2005-06-01 00:00:00
abstract：:The quality of esophageal voice and speech after laryngectomy depends on several factors. Negative influences are produced by irradiation, resection of the hyoid bone and radical neck dissection. The factors important in esophageal speech were analyzed, with consideration given to the functional morphology of the pseu...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1977-12-01 00:00:00
