Abstract：
:Diphenidine is a dissociative drug that shows several psychotropic effects including euphoria, shifts in perception of reality, hallucinations, and transient anterograde amnesia. In this study, a case of acute intoxication occurring after diphenidine intake is reported. A 30-year-old Caucasian male was hospitalized after he was found in a confused and agitated state and unable to communicate. The physical examination displayed tachycardia, miotic pupils, and increased both body temperature and respiratory rate. After a liquid-liquid extraction procedure, GC/MS analysis revealed the presence of diphenidine in plasma and urine at concentrations of 308 and 631 ng/mL, respectively. Methylphenidate and diclazepam were also detected in the plasma. The clinical progress of the patient was favorable, and his symptoms were cured with a symptomatic treatment. The combined circumstantial elements and toxicological results of the case reported revealed the occurrence of an acute intoxication ascribable to the recreational abuse of diphenidine.
journal_name
J Forensic Scijournal_title
Journal of forensic sciencesauthors
Gerace E,Bovetto E,Corcia DD,Vincenti M,Salomone Adoi
10.1111/1556-4029.13355subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1107-1111issue
4eissn
0022-1198issn
1556-4029journal_volume
62pub_type
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