Abstract:
STUDY DESIGN:An experimental animal study. OBJECTIVE:To investigate the relationship between pain-related behavior and the expression of neurotrophic factors in the dorsal root ganglion (DRG) and spinal cord (SC) using a nucleus pulposus (NP) rat model. SUMMARY OF BACKGROUND DATA:Neurotrophic factors are released from activated glial cells and are associated with pain-related behavior. Nerve growth factor (NGF) is a neurotrophic factor that is induced by inflammation. METHODS:Rats were divided into an NP group (n = 94) and a sham-operated group (n = 46). NP harvested from the tail was applied to the left L5 DRG. Rats in the NP group were then divided into five subgroups: one non-treatment and four treatment groups. In the treatment groups, a dose of anti-NGF antibody or phosphate-buffered saline was administered into the DRG. Behavioral testing was performed to investigate the mechanical withdrawal threshold of the left hind paw for all groups. Immunohistochemical localization of NGF, phosphorylated p38 (p38), and brain-derived neurotrophic factor (BDNF) in the DRGs and SCs was performed, and the numbers of immunoreactive (IR) cells were counted. RESULTS:The withdrawal threshold in the nontreatment NP group was significantly decreased for 35 days, and that of the middle- and high-dose treatment rats was significantly higher than the phosphate-buffered saline group values. In the DRG, NGF-IR, p38-IR, and BDNF-IR cells were increased for days 21. In the SC, BDNF-IR, and p38-IR cells were increased from days 7 to 21. CONCLUSION:In the DRG, NGF expression increased, mechanical thresholds were reduced, and p38 and BDNF expression was increased in the NP group. p38 and BDNF expression was increased in SC neurons during the same period. Inhibition of NGF may be a potential treatment for neuropathic pain due to lumbar disc herniation. LEVEL OF EVIDENCE:5.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Seki S,Sekiguchi M,Konno SIdoi
10.1097/BRS.0000000000002223subject
Has Abstractpub_date
2018-01-01 00:00:00pages
E7-E15issue
1eissn
0362-2436issn
1528-1159pii
00007632-201801010-00004journal_volume
43pub_type
杂志文章相关文献
SPINE文献大全abstract:STUDY DESIGN:Case report and literature review. OBJECTIVE:To describe a unique case of recurrent cerebral embolisms with "bilateral" atlantoaxial rotational vertebral artery occlusion (RVAO), and review the literature on this rare entity. SUMMARY OF BACKGROUND DATA:The few reports of bilateral bow hunter's stroke (BH...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0000000000000341
更新日期:2014-06-15 00:00:00
abstract:STUDY DESIGN:Prospective study of the sagittal plane alignment of the spine and pelvis in the normal pediatric population. OBJECTIVES:To document the sagittal alignment of the spine and pelvis and its change during growth in the normal pediatric population. SUMMARY OF BACKGROUND DATA:Pelvic morphology as well as sagi...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000132312.78469.7b
更新日期:2004-08-01 00:00:00
abstract:STUDY DESIGN:In vitro cadaveric study. OBJECTIVE:The purpose of this study was to quantify the relative biomechanical protection resulting from "saving a level" in long spinal fusions. SUMMARY OF BACKGROUND DATA:"Saving levels" in spinal deformity surgery is desirable. Constructs with lowest instrumented vertebra (LI...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31821e1106
更新日期:2012-03-01 00:00:00
abstract:STUDY DESIGN:Retrospective comparative cohort study. OBJECTIVE:Assess the incidence, risk factors, and outcomes of recurrent proximal junctional kyphosis (r-PJK) in PJK revision patients. SUMMARY OF BACKGROUND DATA:Several studies have identified the incidence and risk factors for PJK after primary surgery. However, ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003202
更新日期:2020-01-01 00:00:00
abstract::This report describes the development of a technique for reduction and fusion of spondylolisthesis that includes posterior mobilization with alartransverse fusion, halo-femoral traction with the patient in some extension, and finally, anterior interbody fusion of the lumbosacral joint. The report emphasizes the techni...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-197909000-00007
更新日期:1979-09-01 00:00:00
abstract:STUDY DESIGN:retrospective review. OBJECTIVE:to determine if Anterior/Posterior Combined approach spine surgery is associated with an increased risk of pulmonary embolism (PE) compared to Posterior Only approach surgery. SUMMARY OF BACKGROUND DATA:combined anterior/posterior approach spine surgery is associated with ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181cb4717
更新日期:2011-01-15 00:00:00
abstract:STUDY DESIGN:A retrospective study. OBJECTIVE:The aim of this study was to detect risk factors for Adding-on after posterior correction surgery in patients with Lenke 1 or 2 AIS, and to explore whether Adding-on Index could be used to predict Adding-on effectively. SUMMARY OF BACKGROUND DATA:Adding-on phenomenon is a...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001303
更新日期:2016-04-01 00:00:00
abstract:STUDY DESIGN:A retrospective database study. OBJECTIVE:The goal of this study was to (1) evaluate the trends in the use of electromyography (EMG) for instrumented posterolateral lumbar fusions (PLFs) in the United States and (2) assess the risk of neurological injury following PLFs with and without EMG. SUMMARY OF BA...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001980
更新日期:2017-07-01 00:00:00
abstract:STUDY DESIGN:Validation of a performance scale. OBJECTIVE:The purpose of this study is to investigate adaptation, validity, and reliability of the Turkish version of the Back Performance Scale (BPS). SUMMARY OF BACKGROUND DATA:Low back pain affects people of all ages and causes pain, disability, and psychosocial prob...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002771
更新日期:2019-01-01 00:00:00
abstract:STUDY DESIGN:A numerical study was conducted by simulating in situ contouring (ISC) surgery. OBJECTIVE:To quantify intraoperative correction during ISC surgery. SUMMARY OF BACKGROUND DATA:Surgical techniques correcting scoliosis, like the ISC one, lead to a complex 3-dimensional correction of the spine. Using motion ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181b8eaca
更新日期:2010-02-15 00:00:00
abstract:STUDY DESIGN:A case report of a rare disease entity and review of the literature. OBJECTIVES:To illustrate the occurrence of an unusual disease affecting the spine and spinal canal. SUMMARY OF BACKGROUND DATA:Rosai-Dorman disease is considered an idiopathic benign lymphoproliferative disease that typically occurs in ...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/00007632-200006010-00020
更新日期:2000-06-01 00:00:00
abstract:STUDY DESIGN:Measurement of radiation dose from C-arm fluoroscopy during a simulated intraoperative use in spine surgery. OBJECTIVE.: To investigate scatter radiation doses to specific organs of surgeons during intraoperative use of C-arm fluoroscopy in spine surgery and to provide practical intraoperative guidelines. ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31824589d5
更新日期:2012-06-15 00:00:00
abstract:STUDY DESIGN:A case of bilateral symptomatic facet joint synovial cysts arising in association with calcium pyrophosphate deposition disease is reported. OBJECTIVE:To present a previously unreported cause for symptomatic synovial cysts of the lumbar spine. SUMMARY OF BACKGROUND DATA:Synovial cysts of the facet joints...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200210010-00024
更新日期:2002-10-01 00:00:00
abstract:STUDY DESIGN:Prospective, nonrandomized cohort. OBJECTIVE:Describe the surgical technique and clinical outcome of distraction lumbar laminoplasty with allograft bone block augmentation and interlaminar lumbar instrumented fusion (ILIF) SUMMARY OF BACKGROUND DATA.: ILIF is a recently described technique that may offer ...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0000000000001484
更新日期:2016-04-01 00:00:00
abstract:STUDY DESIGN:Experimental biomechanics of multilevel segments with 0, 1, 2, and 3 vertebral levels of polymethylmethacrylate augmentation. OBJECTIVE:To compare multilevel spinal segments with different numbers (0, 1, 2, and 3) of vertebral levels augmented with polymethylmethacrylate. SUMMARY OF BACKGROUND DATA:The s...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000207466.40955.31
更新日期:2006-04-01 00:00:00
abstract:STUDY DESIGN:Immunohistochemical study of tumor necrosis factor alpha expression in autopsy and surgical specimens of human lumbar intervertebral discs. OBJECTIVES:To investigate the occurrence and localization of tumor necrosis factor alpha in intervertebral disc tissue and to correlate its expression with age and th...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000149186.63457.20
更新日期:2005-01-01 00:00:00
abstract:STUDY DESIGN:A comparative study was conducted. OBJECTIVES:To attempt quantification of the stress in patients with lumbar disc herniation by measuring natural killer cell activity, and to evaluate the assay methodology. SUMMARY OF BACKGROUND DATA:Stressful events may have adverse effects on health. Distress in the p...
journal_title:Spine
pub_type: 临床试验,杂志文章
doi:10.1097/00007632-200210010-00004
更新日期:2002-10-01 00:00:00
abstract:STUDY DESIGN:Survey, subgroup analysis, Q-analysis, and analysis of e-mail exchanges. OBJECTIVE:To assess what influences the choice of priorities for interventions to prevent back-related disability. SUMMARY OF BACKGROUND DATA:Back-related disability results from interaction of physical, psychological, occupational,...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000261035.62523.37
更新日期:2007-04-20 00:00:00
abstract:STUDY DESIGN:Experimental animal study. OBJECTIVES:This study evaluates the in vitro and in vivo transduction efficacy and transgene expression in immune competent and pre-exposed rabbits. SUMMARY OF BACKGROUND DATA:Degenerative disc disease (DDD) continues to pose a substantial clinical problem. Therapeutic options ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000154764.62072.44
更新日期:2005-03-01 00:00:00
abstract:STUDY DESIGN:Finite element and in vitro study. OBJECTIVE:Finite element calculations to delineate a dynamic fixator and confirmation with an in vitro experiment. SUMMARY AND BACKGROUND DATA:In the last few years, there was a paradigm shift from rigid to dynamic fixation of spinal segments. However, some so-called dy...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181920e9c
更新日期:2009-02-01 00:00:00
abstract:STUDY DESIGN:A case report. OBJECTIVE:To describe a case of traumatic lumbosacral spondyloptosis and present a literature review. SUMMARY OF BACKGROUND DATA:Traumatic spondyloptosis is a very rare injury caused by high-energy trauma. Eight cases of traumatic spondyloptosis of L5-S1 have been reported, including only ...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0b013e318268c08a
更新日期:2012-10-15 00:00:00
abstract:STUDY DESIGN:The incidence and risk factors of postoperative delirium were retrospectively examined in patients who had spine surgery for degenerative lumbar disease. OBJECTIVE:The aim of this study is to examine the incidence, pre- and postoperative risk factors and clinical results of postoperative delirium after sp...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181c423fc
更新日期:2010-08-15 00:00:00
abstract::STUDY DESIGN. A qualitative and semiquantitative study of the morphology of the human thoracolumbar transversospinal (TSP) muscles. OBJECTIVE. To further define the functional morphology of the thoracolumbar TSP muscles. SUMMARY OF BACKGROUND DATA. The TSP muscle group plays an important role in vertebral function but...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181f79629
更新日期:2011-07-15 00:00:00
abstract:STUDY DESIGN:Case report of late postoperative complication. SUMMARY OF BACKGROUND DATA:There have been a number of reports of migration and extrusion of cervical fusion instrumentation. The majority of such cases have a benign outcome. To our knowledge, cervical instrumentation extrusion resulting in prevertebral abs...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000186861.82651.00
更新日期:2005-11-15 00:00:00
abstract::The aim of this study is to see how the spinal sagittal configuration and mobility in 127 patients with idiopathic scoliosis are influenced by increasing scoliotic deformity and to determine when this deformity gets clinically significant compared to controls (n = 92). In patients with thoracic curves the degrees of t...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198804000-00008
更新日期:1988-04-01 00:00:00
abstract:STUDY DESIGN:Retrospective Cohort OBJECTIVE.: Investigate and establish minimum clinically important differences (MCID) for PHQ-9 among patients undergoing minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). SUMMARY OF BACKGROUND:Spine surgery is linked to postoperative improvements in anxiety, depre...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003853
更新日期:2020-12-07 00:00:00
abstract:STUDY DESIGN:Retrospective clinical study. OBJECTIVE:The aim of this study was to evaluate retrospectively the safety and efficacy of 1-stage surgical treatment of 45 consecutive patients, who had progressive congenital spinal deformity associated with split spinal cord malformation (SSCM). SUMMARY OF BACKGROUND DATA...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3182608988
更新日期:2012-12-01 00:00:00
abstract:STUDY DESIGN:A case report of Trichosporon asahii spondylodiscitis. OBJECTIVE:To report the first case of T. asahii spondylodiscitis that developed in a healthy woman at the site of an open lumbar discectomy. SUMMARY OF BACKGROUND DATA:Trichosporon is a genus of basidiomycetous yeasts that is common in nature and a m...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181642a7c
更新日期:2008-02-15 00:00:00
abstract:STUDY DESIGN:A report of two cases using custom-manufactured pedicle screws for revision spinal arthrodesis for pseudarthrosis in the setting of widely dilated pedicle screw tracts. OBJECTIVE:To present surgical outcomes of a previously unreported treatment for pseudarthrosis with widely dilated pedicle screw tracts. ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31820285cf
更新日期:2011-10-15 00:00:00
abstract:STUDY DESIGN:Retrospective review. OBJECTIVE:To define the geographic variation in costs of anterior cervical discectomy and fusion (ACDF) and posterolateral fusion (PLF). SUMMARY OF BACKGROUND DATA:ACDF and lumbar PLF are common procedures that are used in the treatment of spinal pathologies. To optimize value, both...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001022
更新日期:2015-09-01 00:00:00