Abstract:
BACKGROUND:Staphylococcus aureus is a frequently implicated pathogen in chronic rhinosinusitis (CRS). S. aureus may promote commensalism by downregulating pro-inflammatory T cell host responses via an IL-10 mediated pathway. This finding, coupled with the observation that S. aureus and CD8+ T cell numbers are inversely correlated in CRS mucosa, suggests that S. aureus may evade immune destruction via IL-10 induction. To support this hypothesis, we evaluated i) whether IL-10 levels differ in CRS compared to controls (CTL) using microarray and immunohistochemistry and ii) whether IL-10 levels correlate with S. aureus and CD8+ T cell levels. METHODOLOGY:Sinus epithelial brush samples from 12 patients undergoing ESS for CRS and 10 CTLs underwent microarray analysis of IL-10 gene expression. Microarray results were verified on simultaneously obtained surgical biopsy samples by immunohistochemistry staining for IL-10. Potential mechanisms were assessed by immunohistochemistry for CD8+ T cells and S. aureus. RESULTS:IL-10 gene expression was significantly higher in CRS vs CTL subjects at the time of surgery. Immunohistochemistry confirmed increased levels of intraepithelial IL-10. A strong inverse correlation was observed between intraepithelial IL-10 and CD8+ T cell levels as was intraepithelial IL-10 and S. aureus. CONCLUSION:Elevated IL-10 levels in sinus mucosa may be a potential pathophysiologic feature of CRS in association with a significant downregulation of host CD8+ T cell levels. While S. aureus is believed to play a role in IL-10 induction, a comparatively weaker relationship between S. aureus and IL-10 levels suggests other bacterial species may also induce IL-10 production as a common survival strategy in CRS.
journal_name
Rhinologyjournal_title
Rhinologyauthors
Schwartz JS,Al-Mot S,Endam MF,Alromaih S,Madrenas J,Desrosiers Mdoi
10.4193/Rhin16.199subject
Has Abstractpub_date
2017-09-01 00:00:00pages
227-233issue
3eissn
0300-0729issn
1996-8604pii
1546journal_volume
55pub_type
杂志文章相关文献
RHINOLOGY文献大全abstract:BACKGROUND:Monoclonal antibodies have been proposed as a novel therapy in patients suffering from chronic rhinosinusitis with nasal polyposis (CRSwNP). The purpose of this systematic review was to evaluate their efficacy and safety. METHODOLOGY:A literature search was performed in MEDLINE, Web of Science, the Cochrane...
journal_title:Rhinology
pub_type: 杂志文章,评审
doi:10.4193/Rhin17.156
更新日期:2018-03-01 00:00:00
abstract::The incidence of Japanese cedar pollinosis is estimated to be about 13% of the Japanese population. In Japan it is generic to wear a facemask and eyeglasses to prevent pollen inhalation. We examined the usefulness of a facemask and eyeglasses in cooperation with volunteers. The number of pollen particles in the nasal ...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2005-12-01 00:00:00
abstract::Massive epistaxis following blunt craniofacial trauma should alert clinicians to possible traumatic internal carotid artery (ICA) aneurysm. This article describes a case of a 46-year-old female patient with traumatic ICA pseudoaneurysm presenting similar to a sphenoid sinus mass lesion. Massive bleeding occurred durin...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2007-12-01 00:00:00
abstract::Pleomorphic adenoma is the most frequent tumor of the major salivary glands. It is rarely located in the lacrymal glands and is unusual in the nasal cavity. A rare case of a pleomorphic adenoma of the nose is presented along with a review of the literature. The use of nasal endoscopy in removing tumors of the nose and...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
abstract::The differences in the shape and size of the nose have been proposed to be an adaptation to climate with broad noses (platyrrhine) evolving in a warm humid environment where there was little need for air conditioning and narrow noses (leptorrhine) evolving in colder climates where the air needed more warming. The main...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhino10.105
更新日期:2011-12-01 00:00:00
abstract::The fast development of our field in the last decades has had significant impact on the way we practice our profession. This year my editorials will focus on the impact of these developments on my own daily practice. ...
journal_title:Rhinology
pub_type: 社论
doi:10.4193/Rhin53E1
更新日期:2015-03-01 00:00:00
abstract::Prostaglandins and histamine released during inflammatory and allergic reactions can affect the mucociliary system in different ways. By studying the effect of these mediators on ciliary beat frequency (CBF) with a photo-electrical technique in airway explants from different species, i.e. guinea-pig trachea, rabbit ma...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::From 1978 to 1992, 66 patients (32 women and 34 men) were treated for carcinoma of the nasal vestibule at Odense University Hospital. The treatment was radiotherapy (41 patients), surgery (13 patients) or a combination of the two modalities (12 patients). Twenty-one patients (32%) developed recurrence. Of these, 17 (8...
journal_title:Rhinology
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:We aimed to compare the prevalence and risk factors of chronic rhinosinusitis (CRS) using two different diagnostic criteria with the same statistical data from the Korean National Health and Nutrition Examination Survey in 2009. METHODS:Symptom-based CRS was defined as CRS diagnosed by questionnaires relate...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhin15.157
更新日期:2016-12-01 00:00:00
abstract::The proportions of subjects who attained transnasal pressure and flow values of different magnitudes during spontaneous nasal breathing at rest were determined. Several co-ordinate points on transnasal pressure: flow curves generated by 77 (34 M, 43 F) healthy Japanese subjects aged 15-65 years were examined. By poste...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:The information currently available concerning carbon nanotubes toxicity is disturbing and conflicting. Moreover, little is known about their effect on the nasal cavities, which are the first target for nanoparticles. MATERIAL AND METHOD:We investigated the cytotoxicity (50 to 0.5 microg/mL) of double-walle...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhino10.256
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To analyze the surgical results after Functional Endoscopic Sinus Surgery (FESS) in patients with paranasal sinus fungus ball. MATERIAL AND METHODS:Retrospective analysis of the results of FESS performed in 175 patients suffering from paranasal sinus fungus balls. RESULTS:All maxillary (n = 150), sphenoidal...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
abstract::Orbital decompression and, in some cases, decompression of the optic nerve are the principal surgical procedures used for treatment of moderate or severe Graves' orbitopathy (GO). Histological examination of the surgical specimens of the ethmoid revealed a wide spectrum of inflammatory mucosal changes. The charts of 6...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2009-06-01 00:00:00
abstract::The authors studied the value of the passive anterior rhinomanometry. In a first group of 28 patients it was possible to determine by a confidence interval test if the type of the airstream was mainly laminar or turbulent . In a second group of 15 test subjects the type of airstream was graphically determined. At the ...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:1980-09-01 00:00:00
abstract:AIM:The prevalence of intracellular Staphylococcus aureus organisms in the nasal mucosa of patients with recurrent infectious rhinosinusitis episodes was studied. METHOD:Twenty-seven consecutive adult patients who failed medical management of chronic rhinosinusitis (CRS) of multiple origins, associated or not with nas...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:The use of nasal packing after functional endoscopic sinus surgery (FESS) is often associated with pain and a feeling of pressure for patients. The aim of the present work was to investigate a modern wound dressing made of polyurethane (Nasopore®) that makes removal of the nasal packing unnecessary and is fo...
journal_title:Rhinology
pub_type: 杂志文章,随机对照试验
doi:10.4193/Rhin13.020
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:This study investigated prospectively the role of human papillomavirus (HPV) in paranasal inverted papilloma (IP). METHODS:HPV presence and viral load and physical status of HPV-16 were examined by polymerase chain reaction-based methods using fresh frozen samples obtained from 13 patients with IP (IP group...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhino11.106
更新日期:2012-03-01 00:00:00
abstract::This survey-based study was conducted to determine the characteristics that influence the diagnosis and treatment patterns of acute maxillary sinusitis among general practitioners in France. Questionnaires were sent to 467 physicians and requested to be completed for the next 4 adult (≥ 15 years) patients diagnosed wi...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhino09.126
更新日期:2011-03-01 00:00:00
abstract::The last 20 years of the last century, that sounds long ago but was actually the time that many of us already practiced in Rhinology or received their training, was I think the time of endoscopic sinus surgery. We learned all the possibilities of the endoscope, first mainly in limited inflammatory disease but later al...
journal_title:Rhinology
pub_type: 社论
doi:10.4193/Rhin53E3
更新日期:2015-09-01 00:00:00
abstract::During 4 weeks of the grass pollen season in the south of Sweden 27 patients with seasonal allergic rhinitis were treated topically with a beta-adrenoceptor stimulant, KWD 2131, which in an earlier rhinomanometric study had shown a prophylactic effect at nasal allergen provocations in hay-fever patients. A clinical ef...
journal_title:Rhinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1982-09-01 00:00:00
abstract::In this study we explored long term outcomes of patients with nasal stuffiness and high nasal airway resistance (NAR) that did not undergo nasal surgery. The same investigation was repeated on average 8 years after a baseline investigation with an ENT-examination, a rhinomanometric survey and a rhinomanometry. We did ...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Different from rhinoliths, the paranasal gossypiboma is a foreign body, such as a surgical sponge, left in the nasal cavity. It is a rare, frequently misdiagnosed disease that has rarely been reported. We summarize its clinical characteristics, management, and possible risk factors. METHODOLOGY:We reviewed ...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhin16.341
更新日期:2017-09-01 00:00:00
abstract::The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integrated care pathways in ARS an...
journal_title:Rhinology
pub_type: 杂志文章,实务指引
doi:10.4193/Rhin20.600
更新日期:2020-02-20 00:00:00
abstract:BACKGROUND:Allergic rhinitis (AR) is a highly prevalent disease worldwide. Although a number of studies have described AR, no studies compared children and adult AR populations. The objective was to compare the AR characteristics between two AR cohorts of children and adults. METHODS:Two AR cohorts (children and adult...
journal_title:Rhinology
pub_type: 杂志文章,多中心研究
doi:10.4193/Rhin17.074
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Anatomical studies of the rabbit paranasal cavities are impelled by the increasing interest in the rabbit model to investigate human sinusitis. Although several such studies have already been performed, the topography of the rabbit dorsal conchal and maxillary sinuses is described ambiguously and the existen...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhin09.193
更新日期:2010-09-01 00:00:00
abstract::The possible occurrence of adrenergic and non-adrenergic vasoconstrictor mechanisms has been studied in human nasal mucosa biopsies. The tissue contractions (reflecting vascular tone variation) in response to exogenous noradrenaline (NA), neuropeptide Y (NPY) and somatostatin (SOM) were measured in vitro. Dose-depende...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVES:To demonstrate that computer-assisted endoscopic management of inverted papillomas yields excellent long-term results in terms of preventing recurrence and minimizing significant morbidity and mortality. METHODS:A retrospective chart review of patients who are being followed up for tumour recurrence or have...
journal_title:Rhinology
pub_type: 杂志文章
doi:10.4193/Rhin09.105
更新日期:2010-09-01 00:00:00
abstract::Endonasal sinus surgery aims at the preservation of a lining mucosa in the reventilated and redrained cavities. It can, therefore, be confined to the removal of narrowing bone at the "isthmus" of the ducts or windows. Transnasal ethmoidectomy for diffuse polyposis consists of the removal of the ethmoidal cell septa, i...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:1981-03-01 00:00:00
abstract::With chronic maxillary sinusitis the pathological changes in the diseased mucosa used to be considered irreversible, thus necessitating its radical removal, which is only possible with the Caldwell-Luc operation. The discovery of the reversibility of the pathology caused a shift from the Caldwell-Luc towards endonasal...
journal_title:Rhinology
pub_type: 杂志文章,评审
doi:
更新日期:1988-03-01 00:00:00
abstract::Although smoking is a widely spread habit, its effect on olfaction has not been clearly established. The aim of this study was to investigate the effect of cigarette smoking on the olfactory function, using the "Sniffin' Sticks" test. Sixty-five smokers were studied, with a median period of smoking of 10 years (range:...
journal_title:Rhinology
pub_type: 杂志文章
doi:
更新日期:2007-12-01 00:00:00