Japanese encephalitis vaccines: Immunogenicity, protective efficacy, effectiveness, and impact on the burden of disease.

abstract：:Following the introduction of universal immunization against rotavirus, concerns were raised regarding pathogen-replacement of rotavirus by norovirus. The study aim was to examine the incidence and characteristics and norovirus gastroenteritis before and after the introduction of universal rotavirus immunization in Is...

journal_title：Human vaccines & immunotherapeutics

authors： Muhsen K,Kassem E,Rubenstein U,Goren S,Ephros M,Shulman LM,Cohen D

更新日期：2019-01-01 00:00:00

abstract：:Cancer progression depends on stepwise accumulation of oncogenic mutations and a select group of growth factors essential for tumor growth, metastasis and angiogenesis. Agents blocking the epidermal growth factor receptor (EGFR, also called HER1 and ERBB1) and the co-receptor called HER2/ERBB2 have been approved over ...

journal_title：Human vaccines & immunotherapeutics

authors： Gaborit N,Lindzen M,Yarden Y

更新日期：2016-03-03 00:00:00

abstract：:Better adjuvants are needed for vaccines against seasonal influenza. TLR7 agonists are potent activators of innate immune responses and thereby may be promising adjuvants. Among the imidazoquinoline compounds, 1-benzyl-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine (BBIQ) was reported to be a highly active TLR7 agonist but...

journal_title：Human vaccines & immunotherapeutics

authors： Kaushik D,Dhingra S,Patil MT,Piplani S,Khanna V,Honda-Okubo Y,Li L,Fung J,Sakala IG,Salunke DB,Petrovsky N

更新日期：2020-08-02 00:00:00

abstract：:Based on an increasingly extensive literature expressing the large interest in the field, this paper gives an overview of different aspects of influenza prevention in children. It relies on paradoxes. First, the heaviest part of the burden is well demonstrated in the youngest infants by numerous epidemiological data e...

journal_title：Human vaccines & immunotherapeutics

authors： Olivier CW

更新日期：2012-01-01 00:00:00

abstract：:A cohort of 81 HIV-infected participants received seasonal trivalent inactivated influenza vaccine (TIV) and their humoral responses were monitored using hemagglutination inhibition (HAI) assay and enzyme-linked immunosorbent assay (ELISA). Three weeks after the vaccination, the percentage of the cohort that had an HA...

journal_title：Human vaccines & immunotherapeutics

authors： Lau YF,Tang LH,Chien Lye D,Ooi EE,Leo YS

更新日期：2017-03-04 00:00:00

abstract：:The development of a successful vaccine, which should elicit a combination of humoral and cellular responses to control or prevent infections, is the first step in protecting against infectious diseases. A vaccine may protect against bacterial, fungal, parasitic, or viral infections in animal models, but to be effecti...

journal_title：Human vaccines & immunotherapeutics

authors： Zheng Z,Diaz-Arévalo D,Guan H,Zeng M

更新日期：2018-07-03 00:00:00

abstract：:Most influenza vaccines in Mexico are trivalent, containing two influenza A strains and a single B strain. Quadrivalent influenza vaccines (QIVs) extend protection by including an additional B strain to cover both co-circulating B lineages. Here, we retrospectively estimated how a switch to QIV in Mexico would have im...

journal_title：Human vaccines & immunotherapeutics

authors： Ruiz-Palacios GM,Beigel JH,Guerrero ML,Bellier L,Tamayo R,Cervantes P,Alvarez FP,Galindo-Fraga A,Aguilar-Ituarte F,Lopez JG

更新日期：2020-04-02 00:00:00

abstract：:Nationally, human papillomavirus (HPV) vaccination rates fall short of the Healthy People 2020 goal of 80% completion. Although strategies to increase these rates exist, low rates persist. We used concept mapping with state-level stakeholders to better understand barriers and facilitators to HPV vaccination. Concept m...

journal_title：Human vaccines & immunotherapeutics

authors： Ryan G,Avdic L,Daly E,Askelson N,Farris PE,Shannon J,McRee AL,Hanson J,Kenyon DB,Seegmiller L

更新日期：2020-12-17 00:00:00

abstract：:Vaccine information of varying quality is available through many different sources. We describe the creation, release and utilization of ReadyVax, a new mobile smartphone app providing access to trustworthy, evidence-based vaccine information for a target audience of healthcare providers, pharmacists, and patients (in...

journal_title：Human vaccines & immunotherapeutics

authors： Bednarczyk RA,Frew PM,Salmon DA,Whitney E,Omer SB

更新日期：2017-05-04 00:00:00

abstract：:The thymus is a largely neglected organ but plays a significant role in the regulation of adaptive immune responses. The effect of aging on the thymus and immune senescence is well established, and the resulting inflammaging is found to be implicated in the development of many chronic diseases including atherosclerosi...

journal_title：Human vaccines & immunotherapeutics

authors： Kellogg C,Equils O

更新日期：2020-10-16 00:00:00

abstract：:The present study evaluated the safety and immunogenicity of the 2013/2014 trivalent surface antigen inactivated subunit seasonal influenza virus vaccine Fluvirin® in healthy adults (18 - ≤ 60 years) and elderly (>60 years). The vaccine contained 15 µg haemagglutinin protein from each of influenza A/California/7/2009 ...

journal_title：Human vaccines & immunotherapeutics

authors： Roggelin L,Vinnemeier CD,Meyer S,Witte K,Marx L,Theeß W,Burchard GD,Rolling T,Cramer JP

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:In adults with a tetanus-prone injury, combined vaccines such as Tdap-IPV (REPEVAX®) can boost immunity against several diseases simultaneously. This Phase IIIb, parallel-group, open-label trial compared antibody responses to Tdap-IPV and tetanus monovalent vaccine (TMV; Vaccin Tétanique Pasteur® or Tetavax®...

journal_title：Human vaccines & immunotherapeutics

authors： Laurichesse H,Zimmermann U,Galtier F,Launay O,Duval X,Richard P,Sadorge C,Soubeyrand B

更新日期：2012-12-01 00:00:00

abstract：:Rapid population aging has become a major challenge in the industrialized world and progressive aging is a key reason for making improvement in vaccination a cornerstone of public health strategy. An increase in age-related disorders and conditions is likely to be seen in the near future, and these are risk factors fo...

journal_title：Human vaccines & immunotherapeutics

authors： Esposito S,Bonanni P,Maggi S,Tan L,Ansaldi F,Lopalco PL,Dagan R,Michel JP,van Damme P,Gaillat J,Prymula R,Vesikari T,Mussini C,Frank U,Osterhaus A,Celentano LP,Rossi M,Guercio V,Gavazzi G

更新日期：2016-07-02 00:00:00

abstract：:Typhax is an investigational typhoid fever vaccine candidate that was GMP manufactured applying Protein Capsular Matrix Vaccine (PCMV) technology. It consists of Vi polysaccharide antigen, derived from S. Typhi, non-covalently entrapped in a glutaraldehyde catalyzed cross-linked α-poly-L-lysine and CRM197 protein matr...

journal_title：Human vaccines & immunotherapeutics

authors： Griffin TJ 4th,Thanawastien A,Cartee RT,Mekalanos JJ,Killeen KP

更新日期：2019-01-01 00:00:00

abstract：:A 9-valent HPV (9vHPV) vaccine has been developed to protect against HPV type 6/11/16/18/31/33/45/52/58-related infection and disease. Previous safety analyses from 7 clinical trials conducted in 9vHPV vaccine recipients 9-26 years of age, including comparisons of 9vHPV and quadrivalent HPV (qHPV) vaccines in girls an...

journal_title：Human vaccines & immunotherapeutics

authors： Moreira ED,Giuliano AR,de Hoon J,Iversen OE,Joura EA,Restrepo J,Van Damme P,Vandermeulen C,Ellison MC,Krick A,Shields C,Heiles B,Luxembourg A

更新日期：2018-02-01 00:00:00

abstract：:The immune system responds to tumor cells. The challenge has been how to effectively use these responses to treat or protect against cancer. Toward the goal of developing a cancer vaccine, we are pursuing methodologies for the discovery and testing of useful antigens. We present an array-based approach for discovering...

journal_title：Human vaccines & immunotherapeutics

authors： Whittemore K,Sykes K

更新日期：2013-10-01 00:00:00

abstract：:MENK, a penta-peptide is considered as being involved in the regulatory feedback loop between the immune and neuroendocrine systems, with marked modulation of various functions of human immune cells. The aim of the present work was to investigate change of lymphocyte subpopulations in peripheral blood of 50 cancer pat...

journal_title：Human vaccines & immunotherapeutics

authors： Wang Q,Gao X,Yuan Z,Wang Z,Meng Y,Cao Y,Plotnikoff NP,Griffin N,Shan F

更新日期：2014-01-01 00:00:00

abstract：:The present study is to measure the expression of programmed death (PD)-1 / programmed death ligand-1 (PD-L1) negative costimulatory molecules, soluble format sPD-1 in patients with immune thrombocytopenia (ITP), and to investigate their correlation with the secretion of cytokines. A total of 35 patients with ITP were...

journal_title：Human vaccines & immunotherapeutics

authors： Wang Y,Pang N,Wang X,Liu Y,Wang X,Wang L,Sun M,Yasen H,Zhao F,Fan W,Guo X,Ding J

更新日期：2018-04-03 00:00:00

abstract：:Alzheimer disease is a devastating chronic disease without adequate therapy. More than 10 years ago, it was demonstrated in transgenic mouse models that vaccination may be a novel, disease-modifying therapy for Alzheimer. Subsequent clinical development has been a roller-coaster with some positive and many negative ne...

journal_title：Human vaccines & immunotherapeutics

authors： Fettelschoss A,Zabel F,Bachmann MF

更新日期：2014-01-01 00:00:00

abstract：:Pertussis is a highly contagious respiratory disease caused by Bordetella pertussis. However, after the introduction of the whole-cell pertussis vaccine (wP), the annual incidence rates of the disease progressively declined. Despite this result, the inclusion of wP in the national immunization schedule of infants and ...

journal_title：Human vaccines & immunotherapeutics

authors： Esposito S,Principi N

更新日期：2018-01-01 00:00:00

abstract：:Hepatitis B virus (HBV) remains a challenging public-health issue in China. Hepatitis B carriers and patients suffer not only physically but also experience strong discrimination and stigma. China's rural population is 629 million. Thus, there is a great need to understand the situation surrounding HBV-related discrim...

journal_title：Human vaccines & immunotherapeutics

authors： Yu L,Wang J,Zhu D,Leng A,Wangen KR

更新日期：2016-01-01 00:00:00

abstract：:Since 2006, some Italian Regions introduced the active offer of measles, mumps, rubella, and varicella (MMRV) vaccine for all newborns during the second years of life. In 2011, Italian Drug Authority (AIFA) recommended the discontinuation of the MMRV use for an increased risk of febrile seizures following vaccination;...

journal_title：Human vaccines & immunotherapeutics

authors： Stefanizzi P,De Nitto S,Patano F,Bianchi FP,Ferorelli D,Stella P,Ancona D,Bavaro V,Tafuri S

更新日期：2020-08-02 00:00:00

abstract：BACKGROUND:Many low- to middle-income countries have completed or are in the process of transitioning from high or intermediate to low endemicity for hepatitis A virus (HAV). Because the risk of severe hepatitis A disease increases with age at infection, decreased incidence that leaves older children and adults suscept...

journal_title：Human vaccines & immunotherapeutics

authors： Van Effelterre T,Guignard A,Marano C,Rojas R,Jacobsen KH

更新日期：2017-08-03 00:00:00

abstract：:Kyasanur Forest Disease (KFD) is a tick-borne hemorrhagic fever of human, caused by Kyasanur forest disease virus (KFDV) in India. The tick, Haemaphysalis spinigera, has been incriminated as the vector of KFDV. In human, KFD clinically presents with high fever, frontal headache, and severe myalgia, followed by bleedin...

journal_title：Human vaccines & immunotherapeutics

authors： Rajaiah P

更新日期：2019-01-01 00:00:00

abstract：:Maternal immunization has the potential to reduce the burden of infectious diseases in the pregnant woman and her infant. Many countries now recommend immunization against influenza at any stage of pregnancy and against pertussis in the third trimester. Despite evidence of the safety and effectiveness of these vaccine...

journal_title：Human vaccines & immunotherapeutics

authors： Marshall H,McMillan M,Andrews RM,Macartney K,Edwards K

更新日期：2016-04-02 00:00:00

abstract：:The four-component meningococcal serogroup B vaccine (4CMenB) contains antigens present in the majority of meningococci causing invasive meningococcal disease (IMD) and may potentially offer protection against strains belonging to non-B serogroups. This study aimed to evaluate the ability of 4CMenB-induced antibodies ...

journal_title：Human vaccines & immunotherapeutics

authors： Fazio C,Biolchi A,Neri A,Tomei S,Vacca P,Ambrosio L,Palmieri A,Mori E,La Gaetana R,Pizza M,Giuliani MM,Serino L,Stefanelli P

更新日期：2021-01-31 00:00:00

abstract：:Cancer immunotherapy has seen a tremendous number of failures and only few recent regulatory successes. This is a review dedicated to determine major regulatory and developmental issues around cancer immunotherapeutics. A three pillar approach should be used in setting a development path: discovery platforms and suffi...

journal_title：Human vaccines & immunotherapeutics

authors： Kudrin A

更新日期：2012-09-01 00:00:00

abstract：:Different strategies have been proposed for the development of protein subunit vaccine candidates for tuberculosis (TB), which shows better safety than other types of candidates and the currently used Bacillus Calmette-Guérin (BCG) vaccine. In order to develop more effective protein subunits depending on the mechanism...

journal_title：Human vaccines & immunotherapeutics

authors： Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X

更新日期：2015-01-01 00:00:00

abstract：:The practice of passive immunization with human immune globulin (IG) for the control of communicable diseases (measles, rubella and hepatitis A) differs somewhat between Australia, the United States of America, the United Kingdom, and New Zealand despite the many similarities of these countries, including disease inci...

journal_title：Human vaccines & immunotherapeutics

authors： Young MK,Cripps AW

更新日期：2013-09-01 00:00:00

abstract：:Eight months after the mass immunization campaign of November 2015 against measles and rubella in the southeast of Iran, in order to evaluate the sero-immunity level of the people living in the mentioned region, a serosurvey study was performed. Using a multi-stage probability proportional to size cluster sampling, th...

journal_title：Human vaccines & immunotherapeutics

authors： Izadi S,Zahraei SM,Mokhtari-Azad T

更新日期：2018-06-03 00:00:00