MetaTopics: an integration tool to analyze microbial community profile by topic model.

abstract：BACKGROUND:Cichlid fishes have evolved remarkably diverse reproductive, social, and feeding behaviors. Cell-to-cell signaling molecules, notably neuropeptides and peptide hormones, are known to regulate these behaviors across vertebrates. This class of signaling molecules derives from prohormone genes that have undergo...

journal_title：BMC genomics

authors： Hu CK,Southey BR,Romanova EV,Maruska KP,Sweedler JV,Fernald RD

更新日期：2016-08-19 00:00:00

abstract：:ᅟ: Upon publication of the original article [1], the authors had flagged that there was an error in Fig. 1c, as the key in this figure was displaying incorrectly. The colours had not displayed in the key in the final published article, and instead appear as plain white. ...

journal_title：BMC genomics

authors： Hohmann N,Koch MA

更新日期：2018-04-11 00:00:00

abstract：BACKGROUND:Oxidative stress is a consequence of normal and abnormal cellular metabolism and is linked to the development of human diseases. The effective functioning of the pathway responding to oxidative stress protects the cellular DNA against oxidative damage; conversely the failure of the oxidative stress response ...

journal_title：BMC genomics

authors： Sridharan S,Layek R,Datta A,Venkatraj J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Sugarcane (Saccharum spp.) is predominantly an autopolyploid plant with a variable ploidy level, frequent aneuploidy and a large genome that hampers investigation of its organization. Genetic architecture studies are important for identifying genomic regions associated with traits of interest. However, due t...

journal_title：BMC genomics

authors： Balsalobre TW,da Silva Pereira G,Margarido GR,Gazaffi R,Barreto FZ,Anoni CO,Cardoso-Silva CB,Costa EA,Mancini MC,Hoffmann HP,de Souza AP,Garcia AA,Carneiro MS

更新日期：2017-01-11 00:00:00

abstract：BACKGROUND:Previous investigations of phylogeny in Cervus recovered many clades without whole genomic support. METHODS:In this study, the genetic diversity and phylogeny of 5 species (21 subspecies/populations from C. unicolor, C. albirostris, C. nippon, C. elaphus and C. eldii) in the genus Cervus were analyzed using...

journal_title：BMC genomics

authors： Hu P,Shao Y,Xu J,Wang T,Li Y,Liu H,Rong M,Su W,Chen B,Cui S,Cui X,Yang F,Tamate H,Xing X

更新日期：2019-05-17 00:00:00

abstract：BACKGROUND:Housekeeping (HK) genes are ubiquitously expressed in all tissue/cell types and constitute a basal transcriptome for the maintenance of basic cellular functions. Partitioning transcriptomes into HK and tissue-specific (TS) genes relatively is fundamental for studying gene expression and cellular differentiat...

journal_title：BMC genomics

authors： Zhu J,He F,Song S,Wang J,Yu J

更新日期：2008-04-16 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：BMC genomics

authors： Levin M,Scheibe M,Butter F

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:The increasing resistance of Plasmodium, the malaria parasites, to multiple commonly used drugs has underscored the urgent need to develop effective antimalarial drugs and vaccines. The new direction of genomics-driven target discovery has become possible with the completion of parasite genome sequencing, wh...

journal_title：BMC genomics

authors： Cai H,Gu J,Wang Y

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:In the postgenome era, a prediction of response to treatment could lead to better dose selection for patients in radiotherapy. To identify a radiosensitive gene signature and elucidate related signaling pathways, four different microarray experiments were reanalyzed before radiotherapy. RESULTS:Radiosensiti...

journal_title：BMC genomics

authors： Kim HS,Kim SC,Kim SJ,Park CH,Jeung HC,Kim YB,Ahn JB,Chung HC,Rha SY

更新日期：2012-07-30 00:00:00

abstract：BACKGROUND:Multidrug- (MDR) and extensively drug resistant (XDR) tuberculosis (TB) presents a challenge to disease control and elimination goals. In Lisbon, Portugal, specific and successful XDR-TB strains have been found in circulation for almost two decades. RESULTS:In the present study we have genotyped and sequenc...

journal_title：BMC genomics

authors： Perdigão J,Silva H,Machado D,Macedo R,Maltez F,Silva C,Jordao L,Couto I,Mallard K,Coll F,Hill-Cawthorne GA,McNerney R,Pain A,Clark TG,Viveiros M,Portugal I

更新日期：2014-11-18 00:00:00

abstract：BACKGROUND:Despite the importance of wheat as a major staple crop and the negative impact of diseases on its production worldwide, the genetic mechanisms and gene interactions involved in the resistance response in wheat are still poorly understood. The complete sequence of the rice genome has provided an extremely use...

journal_title：BMC genomics

authors： Cantu D,Yang B,Ruan R,Li K,Menzo V,Fu D,Chern M,Ronald PC,Dubcovsky J

更新日期：2013-03-12 00:00:00

abstract：BACKGROUND:Crocodilians (Order Crocodylia) are an ancient vertebrate group of tremendous ecological, social, and evolutionary importance. They are the only extant reptilian members of Archosauria, a monophyletic group that also includes birds, dinosaurs, and pterosaurs. Consequently, crocodilian genomes represent a gat...

journal_title：BMC genomics

authors： Shan X,Ray DA,Bunge JA,Peterson DG

更新日期：2009-07-14 00:00:00

abstract：BACKGROUND:Deep-sea hydrothermal vents are unique chemoautotrophic ecosystems with harsh conditions. Alvinocaris longirostris is one of the dominant crustacean species inhabiting in these extreme environments. It is significant to clarify mechanisms in their adaptation to the vents. Lysine acetylation has been known to...

journal_title：BMC genomics

authors： Hui M,Cheng J,Sha Z

更新日期：2018-05-10 00:00:00

abstract：BACKGROUND:The principal toxicity of acute organophosphate (OP) pesticide poisoning is the disruption of neurotransmission through inhibition of acetylcholinesterase (AChE). However, other mechanisms leading to persistent effects and neurodegeneration remain controversial and difficult to detect. Because Caenorhabditis...

journal_title：BMC genomics

authors： Lewis JA,Gehman EA,Baer CE,Jackson DA

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:Lipoxygenases (LOXs), a type of non-haem iron-containing dioxygenase, are ubiquitous enzymes in plants and participate in the formation of fruit aroma which is a very important aspect of fruit quality. Amongst the various aroma volatiles, saturated and unsaturated alcohols and aldehydes provide the character...

journal_title：BMC genomics

authors： Li M,Li L,Dunwell JM,Qiao X,Liu X,Zhang S

更新日期：2014-06-07 00:00:00

abstract：BACKGROUND:Genome-wide association studies (GWAS) have identified many individual genes associated with brain imaging quantitative traits (QTs) in Alzheimer's disease (AD). However single marker level association discovery may not be able to address the underlying biological interactions with disease mechanism. RESULT...

journal_title：BMC genomics

authors： Meng X,Li J,Zhang Q,Chen F,Bian C,Yao X,Yan J,Xu Z,Risacher SL,Saykin AJ,Liang H,Shen L,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2020-12-29 00:00:00

abstract：BACKGROUND:Many bacteria can deliver pathogenic proteins (effectors) through type IV secretion systems (T4SSs) to eukaryotic cytoplasm, causing host diseases. The inherent property, such as sequence diversity and global scattering throughout the whole genome, makes it a big challenge to effectively identify the full se...

journal_title：BMC genomics

authors： Wang Y,Wei X,Bao H,Liu SL

更新日期：2014-01-21 00:00:00

abstract：BACKGROUND:About 10% of cases of male infertility are due to the presence of microdeletions within the long arm of the Y chromosome (Yq). Despite the large literature covering this critical issue, very little is known about the pathogenic mechanism leading to spermatogenesis disruption in patients carrying these microd...

journal_title：BMC genomics

authors： Gatta V,Raicu F,Ferlin A,Antonucci I,Scioletti AP,Garolla A,Palka G,Foresta C,Stuppia L

更新日期：2010-06-24 00:00:00

abstract：BACKGROUND:Leishmaniasis is a neglected tropical disease with diverse clinical phenotypes, determined by parasite, host and vector interactions. Despite the advances in molecular biology and the availability of more Leishmania genome references in recent years, the association between parasite species and distinct clin...

journal_title：BMC genomics

authors： Samarasinghe SR,Samaranayake N,Kariyawasam UL,Siriwardana YD,Imamura H,Karunaweera ND

更新日期：2018-11-28 00:00:00

abstract：BACKGROUND:The genome-wide association (GWA) approach represents an alternative to biparental linkage mapping for determining the genetic basis of trait variation. Both approaches rely on recombination to re-arrange the genome, and seek to establish correlations between phenotype and genotype. The major advantages of G...

journal_title：BMC genomics

authors： Cericola F,Portis E,Lanteri S,Toppino L,Barchi L,Acciarri N,Pulcini L,Sala T,Rotino GL

更新日期：2014-10-14 00:00:00

abstract：BACKGROUND:DNA methylation at promoters is largely correlated with inhibition of gene expression. However, the role of DNA methylation at enhancers is not fully understood, although a crosstalk with chromatin marks is expected. Actually, there exist contradictory reports about positive and negative correlations between...

journal_title：BMC genomics

authors： Sharifi-Zarchi A,Gerovska D,Adachi K,Totonchi M,Pezeshk H,Taft RJ,Schöler HR,Chitsaz H,Sadeghi M,Baharvand H,Araúzo-Bravo MJ

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:Spiders (Order Araneae) are essential predators in every terrestrial ecosystem largely because they have evolved potent arsenals of silk and venom. Spider silks are high performance materials made almost entirely of proteins, and thus represent an ideal system for investigating genome level evolution of nove...

journal_title：BMC genomics

authors： Clarke TH,Garb JE,Hayashi CY,Haney RA,Lancaster AK,Corbett S,Ayoub NA

更新日期：2014-05-23 00:00:00

abstract：BACKGROUND:For their transmission, African trypanosomes rely on their blood feeding insect vector, the tsetse fly (Glossina sp.). The ingested Trypanosoma brucei parasites have to overcome a series of barriers in the tsetse fly alimentary tract to finally develop into the infective metacyclic forms in the salivary glan...

journal_title：BMC genomics

authors： Matetovici I,Caljon G,Van Den Abbeele J

更新日期：2016-11-25 00:00:00

abstract：BACKGROUND:The Polima (pol) system of cytoplasmic male sterility (CMS) and its fertility restoration gene Rfp have been used in hybrid breeding in Brassica napus, which has greatly improved the yield of rapeseed. However, the mechanism of the male sterility transition in pol CMS remains to be determined. RESULTS:To in...

journal_title：BMC genomics

authors： An H,Yang Z,Yi B,Wen J,Shen J,Tu J,Ma C,Fu T

更新日期：2014-04-03 00:00:00

abstract：BACKGROUND:TEs pervade mammalian genomes. However, compared with mice, fewer studies have focused on the TE expression patterns in rat, particularly the comparisons across different organs, developmental stages and sexes. In addition, TEs can influence the expression of nearby genes. The temporal and spatial influences...

journal_title：BMC genomics

authors： Dong Y,Huang Z,Kuang Q,Wen Z,Liu Z,Li Y,Yang Y,Li M

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:The Engrailed Homology 1 (EH1) motif is a small region, believed to have evolved convergently in homeobox and forkhead containing proteins, that interacts with the Drosophila protein groucho (C. elegans unc-37, Human Transducin-like Enhancers of Split). The small size of the motif makes its reliable identifi...

journal_title：BMC genomics

authors： Copley RR

更新日期：2005-11-27 00:00:00

abstract：BACKGROUND:Chlamydia pecorum is an important pathogen of domesticated livestock including sheep, cattle and pigs. This pathogen is also a key factor in the decline of the koala in Australia. We sequenced the genomes of three koala C. pecorum strains, isolated from the urogenital tracts and conjunctiva of diseased koala...

journal_title：BMC genomics

authors： Bachmann NL,Fraser TA,Bertelli C,Jelocnik M,Gillett A,Funnell O,Flanagan C,Myers GS,Timms P,Polkinghorne A

更新日期：2014-08-08 00:00:00

abstract：BACKGROUND:Human Malaria is transmitted by mosquitoes of the genus Anopheles. Transmission is a complex phenomenon involving biological and environmental factors of humans, parasites and mosquitoes. Among more than 500 anopheline species, only a few species from different branches of the mosquito evolutionary tree tran...

journal_title：BMC genomics

authors： Martínez-Barnetche J,Gómez-Barreto RE,Ovilla-Muñoz M,Téllez-Sosa J,García López DE,Dinglasan RR,Ubaida Mohien C,MacCallum RM,Redmond SN,Gibbons JG,Rokas A,Machado CA,Cazares-Raga FE,González-Cerón L,Hernández-Martínez S,Rod

更新日期：2012-05-30 00:00:00

abstract：BACKGROUND:The giant panda, one of the most primitive carnivores, is an endangered animal. Although it has been the subject of many interesting studies during recent years, little is known about its genome. In order to promote research on this genome, a bacterial artificial chromosome (BAC) library of the giant panda w...

journal_title：BMC genomics

authors： Liu W,Zhao Y,Liu Z,Zhang Y,Lian Z,Li N

更新日期：2006-11-17 00:00:00

abstract：BACKGROUND:The human gastric pathogen Helicobacter pylori is a paradigm for chronic bacterial infections. Its persistence in the stomach mucosa is facilitated by several mechanisms of immune evasion and immune modulation, but also by an unusual genetic variability which might account for the capability to adapt to chan...

journal_title：BMC genomics

authors： Fischer W,Breithaupt U,Kern B,Smith SI,Spicher C,Haas R

更新日期：2014-04-27 00:00:00