Role of diclofenac sodium and paracetamol on colonic anastomosis: An experimental rodent model.

Abstract:

BACKGROUND:Despite many advances in surgery and technology, colonic anastomosis remains a challenge after colonic resection. The purpose of this study is to compare the safety of using diclofenac sodium and paracetamol for analgesia in colonic anastomosis on rats. METHODS:Wistar-Hannover rats were randomly allocated to four groups: Group 1, sham-operated group; Group 2, control group; Group 3, diclofenac sodium group; Group 4, paracetamol group. After laparotomy, the left colon was transected and a single-layer anastomosis was made with 5/0 vicryl in Groups 2, 3, and 4. Only laparotomy was performed in Group 1. After anastomosis, we administered saline to Group 2, diclofenac sodium to Group 3, and paracetamol to Group 4 for 7 days. Then, all animals were decapitated. The anastomotic region was resected, and bursting pressure was measured. Then, the specimen was sent to the laboratory for histological examination and hydroxyproline analysis. RESULTS:Bursting pressure and hydroxyproline level were significantly higher in the paracetamol group (p<0.05). When we looked at the fibrosis levels of these groups, it was also higher in paracetamol group. CONCLUSION:Bursting pressure, hydroxyproline levels, and fibrosis levels indicate that the perioperative use of paracetamol for analgesia when undergoing colonic anastomosis is safer than diclofenac sodium.

journal_name

Asian J Surg

journal_title

Asian journal of surgery

authors

Gulcicek OB,Solmaz A,Yigitbas H,Ercetin C,Yavuz E,Ozdogan K,Biricik A,Akkalp AK,Uzun H,Kutnu M,Celebi F,Celik A

doi

10.1016/j.asjsur.2017.01.002

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

264-269

issue

3

eissn

1015-9584

issn

0219-3108

pii

S1015-9584(16)30403-1

journal_volume

41

pub_type

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