Correction: Methyl Farnesoate Plays a Dual Role in Regulating Drosophila Metamorphosis.


:[This corrects the article DOI: 10.1371/journal.pgen.1005038.].


PLoS Genet


PLoS genetics


Wen D,Rivera-Perez C,Abdou M,Jia Q,He Q,Liu X,Zyaan O,Xu J,Bendena WG,Tobe SS,Noriega FG,Palli SR,Wang J,Li S




Has Abstract


2017-01-20 00:00:00














  • Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair.

    abstract::Double strand breaks (DSBs) and interstrand crosslinks (ICLs) are toxic DNA lesions that can be repaired through multiple pathways, some of which involve shared proteins. One of these proteins, DNA Polymerase θ (Pol θ), coordinates a mutagenic DSB repair pathway named microhomology-mediated end joining (MMEJ) and is a...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Beagan K,Armstrong RL,Witsell A,Roy U,Renedo N,Baker AE,Schärer OD,McVey M

    更新日期:2017-05-25 00:00:00

  • Genetic variants influence on the placenta regulatory landscape.

    abstract::From genomic association studies, quantitative trait loci analysis, and epigenomic mapping, it is evident that significant efforts are necessary to define genetic-epigenetic interactions and understand their role in disease susceptibility and progression. For this reason, an analysis of the effects of genetic variatio...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Delahaye F,Do C,Kong Y,Ashkar R,Salas M,Tycko B,Wapner R,Hughes F

    更新日期:2018-11-19 00:00:00

  • The microRNA mir-71 inhibits calcium signaling by targeting the TIR-1/Sarm1 adaptor protein to control stochastic L/R neuronal asymmetry in C. elegans.

    abstract::The Caenorhabditis elegans left and right AWC olfactory neurons communicate to establish stochastic asymmetric identities, AWC(ON) and AWC(OFF), by inhibiting a calcium-mediated signaling pathway in the future AWC(ON) cell. NSY-4/claudin-like protein and NSY-5/innexin gap junction protein are the two parallel signals ...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Hsieh YW,Chang C,Chuang CF

    更新日期:2012-01-01 00:00:00

  • Recurrent loss of specific introns during angiosperm evolution.

    abstract::Numerous instances of presence/absence variations for introns have been documented in eukaryotes, and some cases of recurrent loss of the same intron have been suggested. However, there has been no comprehensive or phylogenetically deep analysis of recurrent intron loss. Of 883 cases of intron presence/absence variati...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Wang H,Devos KM,Bennetzen JL

    更新日期:2014-12-04 00:00:00

  • Multiple Independent Retroelement Insertions in the Promoter of a Stress Response Gene Have Variable Molecular and Functional Effects in Drosophila.

    abstract::Promoters are structurally and functionally diverse gene regulatory regions. The presence or absence of sequence motifs and the spacing between the motifs defines the properties of promoters. Recent alternative promoter usage analyses in Drosophila melanogaster revealed that transposable elements significantly contrib...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Merenciano M,Ullastres A,de Cara MA,Barrón MG,González J

    更新日期:2016-08-12 00:00:00

  • Genetic analysis of variation in human meiotic recombination.

    abstract::The number of recombination events per meiosis varies extensively among individuals. This recombination phenotype differs between female and male, and also among individuals of each gender. In this study, we used high-density SNP genotypes of over 2,300 individuals and their offspring in two datasets to characterize r...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Chowdhury R,Bois PR,Feingold E,Sherman SL,Cheung VG

    更新日期:2009-09-01 00:00:00

  • Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction.

    abstract::The mammalian Y chromosome plays a critical role in spermatogenesis. However, the exact functions of each gene in the Y chromosome have not been completely elucidated, partly owing to difficulties in gene targeting analysis of the Y chromosome. Zfy was first proposed to be a sex determination factor, but its function ...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Nakasuji T,Ogonuki N,Chiba T,Kato T,Shiozawa K,Yamatoya K,Tanaka H,Kondo T,Miyado K,Miyasaka N,Kubota T,Ogura A,Asahara H

    更新日期:2017-01-23 00:00:00

  • Heterogeneous genomic molecular clocks in primates.

    abstract::Using data from primates, we show that molecular clocks in sites that have been part of a CpG dinucleotide in recent past (CpG sites) and non-CpG sites are of markedly different nature, reflecting differences in their molecular origins. Notably, single nucleotide substitutions at non-CpG sites show clear generation-ti...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Kim SH,Elango N,Warden C,Vigoda E,Yi SV

    更新日期:2006-10-06 00:00:00

  • A comprehensive genetic characterization of bacterial motility.

    abstract::We have developed a powerful experimental framework that combines competitive selection and microarray-based genetic footprinting to comprehensively reveal the genetic basis of bacterial behaviors. Application of this method to Escherichia coli motility identifies 95% of the known flagellar and chemotaxis genes, and r...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Girgis HS,Liu Y,Ryu WS,Tavazoie S

    更新日期:2007-09-01 00:00:00

  • The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness.

    abstract::The contribution of MEF2 TFs to the tumorigenic process is still mysterious. Here we clarify that MEF2 can support both pro-oncogenic or tumor suppressive activities depending on the interaction with co-activators or co-repressors partners. Through these interactions MEF2 supervise histone modifications associated wit...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Di Giorgio E,Franforte E,Cefalù S,Rossi S,Dei Tos AP,Brenca M,Polano M,Maestro R,Paluvai H,Picco R,Brancolini C

    更新日期:2017-04-18 00:00:00

  • Regulation of transcription elongation in response to osmostress.

    abstract::Cells trigger massive changes in gene expression upon environmental fluctuations. The Hog1 stress-activated protein kinase (SAPK) is an important regulator of the transcriptional activation program that maximizes cell fitness when yeast cells are exposed to osmostress. Besides being associated with transcription facto...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Silva A,Cavero S,Begley V,Solé C,Böttcher R,Chávez S,Posas F,de Nadal E

    更新日期:2017-11-20 00:00:00

  • Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability.

    abstract::In Drosophila, ubiquitous expression of a short Cyclin G isoform generates extreme developmental noise estimated by fluctuating asymmetry (FA), providing a model to tackle developmental stability. This transcriptional cyclin interacts with chromatin regulators of the Enhancer of Trithorax and Polycomb (ETP) and Polyco...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Dardalhon-Cuménal D,Deraze J,Dupont CA,Ribeiro V,Coléno-Costes A,Pouch J,Le Crom S,Thomassin H,Debat V,Randsholt NB,Peronnet F

    更新日期:2018-07-11 00:00:00

  • Developmental transcriptional networks are required to maintain neuronal subtype identity in the mature nervous system.

    abstract::During neurogenesis, transcription factors combinatorially specify neuronal fates and then differentiate subtype identities by inducing subtype-specific gene expression profiles. But how is neuronal subtype identity maintained in mature neurons? Modeling this question in two Drosophila neuronal subtypes (Tv1 and Tv4),...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Eade KT,Fancher HA,Ridyard MS,Allan DW

    更新日期:2012-01-01 00:00:00

  • Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity.

    abstract::Genetic background exerts a strong modulatory effect on the toxicity of aggregation-prone proteins in conformational diseases. In addition to influencing the misfolding and aggregation behavior of the mutant proteins, polymorphisms in putative modifier genes may affect the molecular processes leading to the disease ph...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Gidalevitz T,Krupinski T,Garcia S,Morimoto RI

    更新日期:2009-03-01 00:00:00

  • A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast.

    abstract::ATM and ATR are two redundant checkpoint kinases essential for the stable maintenance of telomeres in eukaryotes. Previous studies have established that MRN (Mre11-Rad50-Nbs1) and ATRIP (ATR Interacting Protein) interact with ATM and ATR, respectively, and recruit their partner kinases to sites of DNA damage. Here, we...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Subramanian L,Nakamura TM

    更新日期:2010-02-05 00:00:00

  • XRN2 Autoregulation and Control of Polycistronic Gene Expresssion in Caenorhabditis elegans.

    abstract::XRN2 is a conserved 5'→3' exoribonuclease that complexes with proteins that contain XRN2-binding domains (XTBDs). In Caenorhabditis elegans (C. elegans), the XTBD-protein PAXT-1 stabilizes XRN2 to retain its activity. XRN2 activity is also promoted by 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT1) through hydrolysis of...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Miki TS,Carl SH,Stadler MB,Großhans H

    更新日期:2016-09-15 00:00:00

  • CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination.

    abstract::At least 25 inherited disorders in humans result from microsatellite repeat expansion. Dramatic variation in repeat instability occurs at different disease loci and between different tissues; however, cis-elements and trans-factors regulating the instability process remain undefined. Genomic fragments from the human s...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Libby RT,Hagerman KA,Pineda VV,Lau R,Cho DH,Baccam SL,Axford MM,Cleary JD,Moore JM,Sopher BL,Tapscott SJ,Filippova GN,Pearson CE,La Spada AR

    更新日期:2008-11-01 00:00:00

  • Allele frequency matching between SNPs reveals an excess of linkage disequilibrium in genic regions of the human genome.

    abstract::Significant interest has emerged in mapping genetic susceptibility for complex traits through whole-genome association studies. These studies rely on the extent of association, i.e., linkage disequilibrium (LD), between single nucleotide polymorphisms (SNPs) across the human genome. LD describes the nonrandom associat...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Eberle MA,Rieder MJ,Kruglyak L,Nickerson DA

    更新日期:2006-09-08 00:00:00

  • Heteroduplex DNA position defines the roles of the Sgs1, Srs2, and Mph1 helicases in promoting distinct recombination outcomes.

    abstract::The contributions of the Sgs1, Mph1, and Srs2 DNA helicases during mitotic double-strand break (DSB) repair in yeast were investigated using a gap-repair assay. A diverged chromosomal substrate was used as a repair template for the gapped plasmid, allowing mismatch-containing heteroduplex DNA (hDNA) formed during reco...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Mitchel K,Lehner K,Jinks-Robertson S

    更新日期:2013-01-01 00:00:00

  • The D4Z4 macrosatellite repeat acts as a CTCF and A-type lamins-dependent insulator in facio-scapulo-humeral dystrophy.

    abstract::Both genetic and epigenetic alterations contribute to Facio-Scapulo-Humeral Dystrophy (FSHD), which is linked to the shortening of the array of D4Z4 repeats at the 4q35 locus. The consequence of this rearrangement remains enigmatic, but deletion of this 3.3-kb macrosatellite element might affect the expression of the ...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Ottaviani A,Rival-Gervier S,Boussouar A,Foerster AM,Rondier D,Sacconi S,Desnuelle C,Gilson E,Magdinier F

    更新日期:2009-02-01 00:00:00

  • Coordinate regulation of stem cell competition by Slit-Robo and JAK-STAT signaling in the Drosophila testis.

    abstract::Stem cells in tissues reside in and receive signals from local microenvironments called niches. Understanding how multiple signals within niches integrate to control stem cell function is challenging. The Drosophila testis stem cell niche consists of somatic hub cells that maintain both germline stem cells and somatic...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Stine RR,Greenspan LJ,Ramachandran KV,Matunis EL

    更新日期:2014-11-06 00:00:00

  • Fate of the H-NS-repressed bgl operon in evolution of Escherichia coli.

    abstract::In the enterobacterial species Escherichia coli and Salmonella enterica, expression of horizontally acquired genes with a higher than average AT content is repressed by the nucleoid-associated protein H-NS. A classical example of an H-NS-repressed locus is the bgl (aryl-beta,D-glucoside) operon of E. coli. This locus ...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Sankar TS,Neelakanta G,Sangal V,Plum G,Achtman M,Schnetz K

    更新日期:2009-03-01 00:00:00

  • Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.

    abstract::N-methyl-D-aspartate receptors (NMDARs), ligand-gated ionotropic glutamate receptors, play key roles in normal brain development and various neurological disorders. Here we use standing variation data from the human population to assess which protein domains within NMDAR GluN1, GluN2A and GluN2B subunits show the stro...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Ogden KK,Chen W,Swanger SA,McDaniel MJ,Fan LZ,Hu C,Tankovic A,Kusumoto H,Kosobucki GJ,Schulien AJ,Su Z,Pecha J,Bhattacharya S,Petrovski S,Cohen AE,Aizenman E,Traynelis SF,Yuan H

    更新日期:2017-01-17 00:00:00

  • ZmMADS47 Regulates Zein Gene Transcription through Interaction with Opaque2.

    abstract::Zeins, the predominent storage proteins in maize endosperm, are encoded by multiple genes and gene families. However, only a few transcriptional factors for zein gene regulation have been functionally characterized. In this study, a MADS-box protein, namely ZmMADS47, was identified as an Opaque2 (O2) interacting prote...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Qiao Z,Qi W,Wang Q,Feng Y,Yang Q,Zhang N,Wang S,Tang Y,Song R

    更新日期:2016-04-14 00:00:00

  • Genetic exchanges are more frequent in bacteria encoding capsules.

    abstract::Capsules allow bacteria to colonize novel environments, to withstand numerous stresses, and to resist antibiotics. Yet, even though genetic exchanges with other cells should be adaptive under such circumstances, it has been suggested that capsules lower the rates of homologous recombination and horizontal gene transfe...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Rendueles O,de Sousa JAM,Bernheim A,Touchon M,Rocha EPC

    更新日期:2018-12-21 00:00:00

  • Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase.

    abstract::Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils generated ahead of transcribing RNA polymerase (RNAP) and the negative supercoils accumulating behind impose severe topological constraints impeding transcription pro...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Ahmed W,Sala C,Hegde SR,Jha RK,Cole ST,Nagaraja V

    更新日期:2017-05-02 00:00:00

  • Integrative and quantitative view of the CtrA regulatory network in a stalked budding bacterium.

    abstract::The Alphaproteobacteria show a remarkable diversity of cell cycle-dependent developmental patterns, which are governed by the conserved CtrA pathway. Its central component CtrA is a DNA-binding response regulator that is controlled by a complex two-component signaling network, mediating distinct transcriptional progra...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Leicht O,van Teeseling MCF,Panis G,Reif C,Wendt H,Viollier PH,Thanbichler M

    更新日期:2020-04-23 00:00:00

  • Post-replication repair suppresses duplication-mediated genome instability.

    abstract::RAD6 is known to suppress duplication-mediated gross chromosomal rearrangements (GCRs) but not single-copy sequence mediated GCRs. Here, we found that the RAD6- and RAD18-dependent post-replication repair (PRR) and the RAD5-, MMS2-, UBC13-dependent error-free PRR branch acted in concert with the replication stress che...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Putnam CD,Hayes TK,Kolodner RD

    更新日期:2010-05-06 00:00:00

  • Pathways of distinction analysis: a new technique for multi-SNP analysis of GWAS data.

    abstract::Genome-wide association studies (GWAS) have become increasingly common due to advances in technology and have permitted the identification of differences in single nucleotide polymorphism (SNP) alleles that are associated with diseases. However, while typical GWAS analysis techniques treat markers individually, comple...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Braun R,Buetow K

    更新日期:2011-06-01 00:00:00

  • DNA dynamics during early double-strand break processing revealed by non-intrusive imaging of living cells.

    abstract::Chromosome breakage is a major threat to genome integrity. The most accurate way to repair DNA double strand breaks (DSB) is homologous recombination (HR) with an intact copy of the broken locus. Mobility of the broken DNA has been seen to increase during the search for a donor copy. Observing chromosome dynamics duri...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Saad H,Gallardo F,Dalvai M,Tanguy-le-Gac N,Lane D,Bystricky K

    更新日期:2014-03-13 00:00:00