[Experiences with the squamous cell carcinoma antigen, a new tumor marker for cancer of the uterine cervix].

Abstract:

:Squamous cell carcinoma (SCC) antigen was first described 1977 by Kato et al. in patients with carcinoma of the cervix uteri. SCC serum levels can be measured with a radioimmunoassay (Abbott), in our investigation 2.0 ng/ml were taken as the upper limit of the standard range. In 35 healthy women there were no elevated SCC serum levels. In only 2 of 50 patients with benign gynaecological diseases SCC was also elevated. 59% of the 102 patients with primary and 70% of the 63 patients with recurrent cervical cancer showed pathologic values, CEA was elevated in 32% and 51% respectively; the mean serum concentrations increased with the stage of the disease. 68% of 142 patients with squamous cell carcinoma had elevated levels, in 5 of 9 adenosquamous carcinomas and in 3 of 14 adenocarcinomas SCC was in the pathological range. 13 of 60 patients with breast, endometrial and ovarian cancer showed elevated values. SCC shows a high specificity and a high sensitivity for squamous cell carcinomas of the cervix uteri. The tumor marker might be helpful in the control of the primary therapy and follow-up of cervical cancer patients.

authors

Meier W,Eiermann W,Stieber P,Fateh-Moghadam A,Hepp H

doi

10.1055/s-2008-1026667

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

625-9

issue

7

eissn

0016-5751

issn

1438-8804

journal_volume

49

pub_type

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