Abstract:
:Tumor treating fields (TTFields) are low-intensity electric fields alternating at an intermediate frequency (200kHz), which have been demonstrated to block cell division and interfere with organelle assembly. This novel treatment modality has shown promise in a variety of tumor types. It has been evaluated in randomized phase 3 trials in glioblastoma (GBM) and demonstrated to prolong progression-free survival (PFS) and overall survival (OS) when administered together with standard maintenance temozolomide (TMZ) chemotherapy in patients with newly diagnosed GBM. TTFields are continuously delivered by 4 transducer arrays consisting each of 9 insulated electrodes that are placed on the patient's shaved scalp and connected to a portable device. Here we summarize the preclinical data and mechanism of action, the available clinical data, and further outlook of this treatment modality in brain tumors and other cancer indications.
journal_name
Neuro Oncoljournal_title
Neuro-oncologyauthors
Hottinger AF,Pacheco P,Stupp Rdoi
10.1093/neuonc/now182subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1338-49issue
10eissn
1522-8517issn
1523-5866pii
now182journal_volume
18pub_type
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