Abstract:
:The transcriptomic effects of Ibuprofen (IBU) in the digestive gland tissue of Mytilus galloprovincialis Lam. specimens exposed at low environmental concentrations (250 ng L(-1)) are presented. Using a 1.7 K feature cDNA microarray along with linear models and empirical Bayes statistical methods 225 differentially expressed genes were identified in mussels treated with IBU across a 15-day period. Transcriptional dynamics were typical of an adaptive response with a peak of gene expression change at day-7 (177 features, representing about 11% of sequences available for analysis) and an almost full recovery at the end of the exposure period. Functional genomics by means of Gene Ontology term analysis unraveled typical mussel stress responses i.e. aminoglycan (chitin) metabolic processes but also more specific effects such as the regulation of NF-κB transcription factor activity.
journal_name
Mar Environ Resjournal_title
Marine environmental researchauthors
Maria VL,Amorim MJ,Bebianno MJ,Dondero Fdoi
10.1016/j.marenvres.2016.05.010subject
Has Abstractpub_date
2016-08-01 00:00:00pages
31-9eissn
0141-1136issn
1879-0291pii
S0141-1136(16)30071-Xjournal_volume
119pub_type
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journal_title:Marine environmental research
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