Effect of Dexmedetomidine Alone for Intravenous Patient-Controlled Analgesia After Gynecological Laparoscopic Surgery: A Consort-Prospective, Randomized, Controlled Trial.


:Gynecological laparoscopic surgery is minimally invasive compared with open surgical approaches, but postoperative pain is generally undermanaged. Pain management strategies related to the procedure-specific efficacy are needed. Many studies have shown that dexmedetomidine (DEX) has opioid-sparing properties. It is not clear whether DEX used alone for intravenous patient-controlled analgesia (PCA) could reduce postoperative pain after an invasive procedure. We hypothesized that DEX alone would reduce postoperative pain in women patients undergoing an elective gynecological laparoscopic procedure.This CONSORT-prospective randomized controlled clinical study aimed to investigate the effects of DEX alone for intravenous PCA after gynecological laparoscopic operation. Forty women patients scheduled for elective gynecological laparoscopy were enrolled into the study at Shandong Cancer Hospital and Institute and randomly allocated into two groups (n = 20 each). In the DEX group (group D), the intravenous PCA protocol was DEX 0.25 μg/kg/h diluted to 100 mL in 0.9% saline. In the fentanyl group (group F), the PCA protocol was fentanyl 20 μg/kg diluted to 100 mL in 0.9% saline. The primary outcome was the mean pain score on a visual analogue scale (VAS) at 6 hours after the operation. The secondary outcomes included the Ramsay sedation score, the incidence of postoperative nausea and vomiting (PONV), satisfaction with pain control, and time to recovery of gastrointestinal function.There were no significant differences in the patients' characteristics and intraoperative measurements (P > 0.05). No patients received rescue analgesic. The mean VAS scores at 6 hours post-operatively were not significantly different between the groups (P > 0.05). The incidence of PONV was less in group D than in group F (P < 0.05). The Ramsay sedation scores were not significantly between the groups (P > 0.05). Satisfaction with pain control was higher and time to recovery of gastrointestinal function was lower in group D (P < 0.05).DEX alone is effective for intravenous patient-controlled analgesia after gynecological laparoscopic surgery without a change in sedation and with fewer side effects, and this effect was associated with better satisfaction with postoperative pain control and earlier recovery of gastrointestinal function.


Medicine (Baltimore)




Wang X,Liu W,Xu Z,Wang F,Zhang C,Wang B,Wang K,Yu J




Has Abstract


2016-05-01 00:00:00
















  • Assessment of cerebral infarction after transient cerebral ischemic attack by ABCD2 score combined with the position of intracranial vascular stenosis.

    abstract::This study aims to investigate the value of the ABCD score combined with the position of the offending vessel stenosis in predicting the risk of transient ischemic attack (TIA) to develop into cerebral infarction.The ABCD score and head magnetic resonance imaging + magnetic resonance angiography (MRA) results of 192 p...


    pub_type: 杂志文章


    authors: Xi HY,Si ZH,Li JC,Zhu JG,Yan HY

    更新日期:2019-04-01 00:00:00

  • Clinical characteristics of Meckel diverticulum in children: A retrospective review of a 15-year single-center experience.

    abstract::Meckel diverticulum is the most prevalent congenital abnormality of the gastrointestinal tract in children. The aim of this study was to review and analyze clinical data on the diagnosis and management of Meckel diverticulum in pediatric patients. The records of 102 pediatric patients (<14 years old) who underwent sur...


    pub_type: 杂志文章


    authors: Lin XK,Huang XZ,Bao XZ,Zheng N,Xia QZ,Chen CD

    更新日期:2017-08-01 00:00:00

  • Laboratory epidemiology of respiratory viruses in a large children's hospital: A STROBE-compliant article.

    abstract::Acute respiratory tract infection (ARTI) is the most common causes of outpatient visit and hospital admission for children. The study aimed to report epidemiological data on respiratory viruses in a university-affiliated children's hospital.The study was a retrospective study conducted in a university affiliated child...


    pub_type: 杂志文章


    authors: Ye S,Wang T

    更新日期:2018-07-01 00:00:00

  • Radiographic anatomical relationship between spinous process and pedicle in thoracolumbar and lumbar spine.

    abstract::Pedicle screws are widely used in spinal surgeries, but it remains technically demanding to place. There are numerous studies on the anatomy of pedicle; however, there is very little insight on the relationship between the pedicle and the spinous process, which is an important part of the spinal posterior column.The a...


    pub_type: 杂志文章


    authors: Cui X,Wang G

    更新日期:2017-05-01 00:00:00

  • The efficacy of dexamethasone on pain management for knee arthroscopy: A meta-analysis of randomized controlled trials.

    abstract:INTRODUCTION:The impact of dexamethasone on pain management for knee arthroscopy remains controversial. We conduct a systematic review and meta-analysis to explore the influence of dexamethasone for knee arthroscopy. METHODS:We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through Octobe...


    pub_type: 杂志文章,meta分析


    authors: Peng C,Li C,Yuan B,Jiao J

    更新日期:2020-04-01 00:00:00

  • Cinobufotalin injection combined with chemotherapy for the treatment of advanced NSCLC in China: A PRISMA-compliant meta-analysis of 29 randomized controlled trials.

    abstract:BACKGROUND AND OBJECTIVE:Cinobufotalin injection (CFI), a kind of Chinese medicine, has been considered as a promising complementary therapy option for advanced non-small cell lung cancer (NSCLC), but their efficacy and safety remain controversial. This study aimed to systematically evaluate the efficacy and safety of ...


    pub_type: 杂志文章,meta分析


    authors: Zhang F,Yin Y,Xu T

    更新日期:2019-08-01 00:00:00

  • Is prophylactic tranexamic acid administration effective and safe for postpartum hemorrhage prevention?: A systematic review and meta-analysis.

    abstract:BACKGROUND:To assess the efficacy and safety of tranexamic acid (TA) in reducing blood loss and lowering transfusion needs for patients undergoing caesarean section (CS) or vaginal delivery (VD). METHODS:An electronic literature search of PubMed, EMBASE, OVID, Cochrane library, Scopus, Central, and Clinical trials.gov...


    pub_type: 杂志文章,meta分析,评审


    authors: Li C,Gong Y,Dong L,Xie B,Dai Z

    更新日期:2017-01-01 00:00:00

  • Association between the persistent organic pollutants and polycystic ovary syndrome: A protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:Current evidence concerning the association between persistent organic pollutants (POPs) and polycystic ovary syndrome (PCOS) is inconsistent. The aim of the present systematic review and meta-analysis is to evaluate the role of POPs in PCOS. METHODS:Databases including PubMed, Embase, Web of Science, and C...


    pub_type: 杂志文章


    authors: Li Y,Zhang MW,Wang YJ

    更新日期:2019-08-01 00:00:00

  • Effects of oxymatrine on the proliferation of human liver cancer Bel-7404 cells: A protocol of systematic review and meta-analysis.

    abstract:BACKGROUND:This study will examine the effects of oxymatrine on the proliferation of human liver cancer Bel-7404 cells (HLCBC). METHODS:This study will search electronic bibliographic databases available in PUBMED, EMBASE, Cochrane Library, Scopus, Cumulative Index to Nursing and Allied Health Literature, China Biolog...


    pub_type: 杂志文章,meta分析


    authors: Li J,Liu ZY,Yu HB,Xue Q,Qu XS

    更新日期:2020-06-05 00:00:00

  • Integrative exploration of genomic profiles for triple negative breast cancer identifies potential drug targets.

    abstract:BACKGROUND:Triple negative breast cancer (TNBC) is high-risk due to its rapid drug resistance and recurrence, metastasis, and lack of targeted therapy. So far, no molecularly targeted therapeutic agents have been clinically approved for TNBC. It is imperative that we discover new targets for TNBC therapy. OBJECTIVES:A...


    pub_type: 杂志文章


    authors: Wang X,Guda C

    更新日期:2016-07-01 00:00:00

  • Validation of the Chinese version of the Mini Sarcopenia Risk Assessment questionnaire in community-dwelling older adults.

    abstract::A new sarcopenia screening tool named Mini Sarcopenia Risk Assessment (MSRA) has recently been developed, which showed a reasonable sensitivity and specificity.We cross-culturally adapted and validated the Chinese version of the MSRA in a population of community-dwelling older adults.We conducted a cross-sectional stu...


    pub_type: 杂志文章


    authors: Yang M,Hu X,Xie L,Zhang L,Zhou J,Lin J,Wang Y,Li Y,Han Z,Zhang D,Zuo Y,Li Y,Wu L

    更新日期:2018-09-01 00:00:00

  • The drug use to treat community-acquired pneumonia in children: A cross-sectional study in China.

    abstract::To evaluate the rationality of drug use to treat community-acquired pneumonia (CAP) in children of a Chinese hospital using a set of developed indicators.We performed a retrospective cross-sectional study in West China Second University Hospital. Hospitalized children (0-18 years old) diagnosed with CAP from October 2...


    pub_type: 杂志文章


    authors: Mi X,Li W,Zhang L,Li J,Zeng L,Huang L,Chen L,Song H,Huang Z,Lin M

    更新日期:2018-11-01 00:00:00

  • A clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis.

    abstract::To investigate the pathogenesis of somatic solid cancer-related cerebral venous sinus thrombosis (CVST).A total of 174 patients with CVST were recruited from the hospital between January 2006 and December 2017 and divided into two groups: (1) somatic cancer-related CVST group, defined as active somatic solid cancer pa...


    pub_type: 杂志文章


    authors: Xian Z,Chen Y,Chen L,Lu Q,Huang G,Qin Q,Zeng J,Liang Z

    更新日期:2019-05-01 00:00:00

  • Lead poisoning in a 16-year-old girl: a case report and a review of the literature (CARE compliant).

    abstract:BACKGROUND:Lead is a toxic element of the environment which leads to major complications once it enters the blood stream, affecting multiple organs and systems of the body. METHODS:We present the case of a 16-year-old girl, diagnosed with lead poisoning after occupational exposure due to the fact that the girl was act...


    pub_type: 杂志文章,评审


    authors: Mărginean CO,Meliţ LE,Moldovan H,Lupu VV,Mărginean MO

    更新日期:2016-09-01 00:00:00

  • Clinical effects of extracorporeal shock-wave therapy and ultrasound-guided local corticosteroid injections for plantar fasciitis in adults: A meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:The argument on whether extracorporeal shock-wave therapy (ESWT) and corticosteroid injections (CSIs) exert an equivalent pain control or which is the better treatment for plantar fasciitis (PF) in adults remains to be resolved. It is important and necessary to conduct a meta-analysis to make a relatively mo...


    pub_type: 杂志文章,meta分析


    authors: Li S,Wang K,Sun H,Luo X,Wang P,Fang S,Chen H,Sun X

    更新日期:2018-12-01 00:00:00

  • Ultrasound image analysis using deep learning algorithm for the diagnosis of thyroid nodules.

    abstract::Fine needle aspiration (FNA) is the procedure of choice for evaluating thyroid nodules. It is indicated for nodules >2 cm, even in cases of very low suspicion of malignancy. FNA has associated risks and expenses. In this study, we developed an image analysis model using a deep learning algorithm and evaluated if the a...


    pub_type: 杂志文章


    authors: Song J,Chai YJ,Masuoka H,Park SW,Kim SJ,Choi JY,Kong HJ,Lee KE,Lee J,Kwak N,Yi KH,Miyauchi A

    更新日期:2019-04-01 00:00:00

  • Pancreaticopleural and pancreaticomediastinal fistula extending to the cervical region, with dysphagia as initial symptom: A case report.

    abstract:RATIONALE:Pancreaticopleural and pancreaticomediastinal fistulas are rare complications of pancreatitis. They are often misdiagnosed and there are no strict guidelines of treatment. In this study, we present a brief report of a combined pancreaticopleural and pancreaticomediastinal fistula extending to the cervical reg...


    pub_type: 杂志文章


    authors: Grudzińska E,Pilch-Kowalczyk J,Kuśnierz K

    更新日期:2019-02-01 00:00:00

  • Effect of high-quality nursing on alleviating depression and anxiety in patients with thyroid cancer during perioperative period: A protocol for systematic review.

    abstract:BACKGROUND:This study will assess the effect of high-quality nursing (HQN) on alleviating depression and anxiety (DA) in patients with thyroid cancer (TC) during perioperative period (PPP). METHODS:We will search the following electronic databases (MEDLINE, EMBASE, PsycINFO, Cochrane Library, CINAHL, Web of Science, C...


    pub_type: 杂志文章


    authors: Cui Y,Li YX

    更新日期:2020-11-06 00:00:00

  • Ten-Year Changes in the Hepatitis B Prevalence in the Birth Cohorts in Korea: Results From Nationally Representative Cross-Sectional Surveys.

    abstract::To compare the prevalence of hepatitis B virus (HBV) infection over a 10-year period in terms of population-level trends, we established hypothetical birth cohorts that represented each 10-year interval age group.We used data from the Korean National Health and Nutrition Examination Surveys conducted between 1998 to 2...


    pub_type: 杂志文章


    authors: Park B,Jung KW,Oh CM,Choi KS,Suh M,Jun JK

    更新日期:2015-10-01 00:00:00

  • The Guillain-Barré syndrome: pulmonary-neurologic correlations.

    abstract::In a retrospective analysis of 40 hospitalized patients with the Guillain-Barré syndrome (GBS), we related the use and outcome of assisted ventilation to specific quantitative details of the neurologic illness. Two patients had an unusually prolonged course: they were ventilated for 374 and 396 days before successful ...


    pub_type: 杂志文章


    authors: Sunderrajan EV,Davenport J

    更新日期:1985-09-01 00:00:00

  • Using an informatics education strategy to resolve the dilemma of teaching transplantation in medical institutions: Multidisciplinary medical team perspectives.

    abstract::In Taiwan, the current survival rate 1 year after transplantation exceeds 80%. However, the number of organ/tissue donors per year in Taiwan is extremely low, resulting in increased mortality. This is also true in Europe and in the United States. Recently, data from the Taiwan Organ Registry and Sharing Center showed ...


    pub_type: 杂志文章,多中心研究


    authors: Hsieh MH,Shih FJ,Sheu SJ,Wang SS,Shih FJ

    更新日期:2018-10-01 00:00:00

  • Inflammation-based Glasgow Prognostic Score in patients with acute ST-segment elevation myocardial infarction: A prospective cohort study.

    abstract::The inflammation-based Glasgow Prognostic Score (GPS), which involves C-reactive protein and serum albumin levels, has been reported to be a strong independent predictor of mortality in many cancers. This study aimed to investigate whether the GPS is associated with mortality in patients with acute ST-segment elevatio...


    pub_type: 杂志文章


    authors: Jia Y,Li D,Cao Y,Cheng Y,Xiao L,Gao Y,Zhang L,Zeng Z,Wan Z,Zeng R

    更新日期:2018-12-01 00:00:00

  • Treatment of chronic obstructive pulmonary disease in patients with different fractional exhaled nitric oxide levels.

    abstract::Some patients with chronic obstructive pulmonary disease (COPD) have eosinophilic inflammation which may be evaluated via the measurement of fractional exhaled nitric oxide (FeNO) like asthma. The aim of this prospective study was to assess whether FeNO levels can be used to identify patients with COPD with eosinophil...


    pub_type: 杂志文章


    authors: Wu YK,Su WL,Huang CY,Yang MC,Chen SY,Lan CC

    更新日期:2018-11-01 00:00:00

  • Intestinal Infarction Caused by Thrombophlebitis of the Portomesenteric Veins as a Complication of Acute Gangrenous Appendicitis After Appendectomy: A Case Report.

    abstract::The clinical symptoms of pylephlebitis caused by acute appendicitis are varied and atypical, which leads to delayed diagnosis and poor outcomes. Here, we report a case of intestinal necrosis caused by thrombophlebitis of the portomesenteric veins as a complication of acute appendicitis after appendectomy. The patient ...


    pub_type: 杂志文章


    authors: Tang R,Tian X,Xie X,Yang Y

    更新日期:2015-06-01 00:00:00

  • Chronic pancreatitis with multiple pseudocysts and pancreatic panniculitis: A case report.

    abstract:RATIONALE:Pancreatic pseudocyst can present single or multiple, inside or outside the pancreas. Pancreatic panniculitis is a rare skin lesion in pancreatic disease patients. The purpose of this study is to report a case of chronic pancreatitis coexisting with multiple pseudocysts and pancreatic panniculitis. PATIENT C...


    pub_type: 杂志文章


    authors: Gu Y,Qian Z

    更新日期:2018-06-01 00:00:00

  • Universal antibiotic prophylaxis may no longer be necessary for patients with acute variceal bleeding: A retrospective observational study.

    abstract::A few decades ago, antibiotic prophylaxis for patients with acute variceal bleeding was reported beneficial. However, endoscopic and systemic therapy for variceal bleeding has dramatically improved since then, so the necessity of prophylactic antibiotics can be questioned. In this study, we reevaluated the efficacy of...


    pub_type: 杂志文章


    authors: Ueno M,Kayahara T,Sunami T,Takayama H,Takabatake H,Morimoto Y,Yamamoto H,Mizuno M

    更新日期:2020-05-01 00:00:00

  • Nocardia bacteremia. Report of 4 cases and review of the literature.

    abstract::Bacteremic nocardiosis is reported rarely. We discuss 4 recent cases seen at our institution and 32 other cases described in the English literature. We found that patients with bacteremic nocardiosis were similar in presentation, risk factors, course, and therapeutic outcome to nonbacteremic patients with nocardiosis....


    pub_type: 杂志文章,评审


    authors: Kontoyiannis DP,Ruoff K,Hooper DC

    更新日期:1998-07-01 00:00:00

  • Challenges in the diagnosis of Boerhaave syndrome: A case report.

    abstract:RATIONALE:Acute chest pain remains one of the most challenging complaints of patients presenting to emergency departments (EDs). The diverse etiologies of chest pain frequently lead to diagnostic and therapeutic challenges. Esophageal perforation is a rare but potentially life-threatening disease. It results in delayed...


    pub_type: 杂志文章


    authors: Tzeng CH,Chen WK,Lu HC,Chen HH,Lee KI,Wu YS,Lee FY

    更新日期:2020-01-01 00:00:00

  • Surgical treatment of pyloric stenosis caused by glyphosate poisoning: A case report.

    abstract:RATIONALE:Oral ingestion of glyphosate can induce gastrointestinal symptoms such as vomiting, abdominal pain, and hematochezia. Timely and effective treatment of pyloric stenosis caused by glyphosate poisoning is important. PATIENT CONCERNS:The patient had a poor appetite, accompanied by nausea and vomiting of a small...


    pub_type: 杂志文章


    authors: Luo W,Lu T,Li F,Qian C,Zhang L,Sun M,Xu Z,Jia Y

    更新日期:2019-07-01 00:00:00

  • Hypertension and selected indicators of health assessment in a population of 19-year-old men subject to military qualifications.

    abstract::Assessment the prevalence of hypertension and its relation to selected indicators of health status and performance, including classification of BMI, obesity classifications, and body structure in a large test group of 19-year-old men.The study was observational-retrospective, and included a group of 17,282 men, aged 1...


    pub_type: 杂志文章


    authors: Chmiel Z,Żal M,Więch P,Bazaliński D,Sałacińska I,Bartusik-Aebisher D,Binkowska-Bury M

    更新日期:2020-05-29 00:00:00