Synaptic alterations associated with depression and schizophrenia: potential as a therapeutic target.

abstract：BACKGROUND:Intestinal microflora contribute to the pathogenesis of inflammatory bowel disease, including ulcerative colitis and Crohn's disease. OBJECTIVE:This review summarizes current clinical knowledge about the role of intestinal microflora in inflammatory bowel disease and their importance as targets for new form...

journal_title：Expert opinion on therapeutic targets

authors： Mitsuyama K,Sata M

更新日期：2008-03-01 00:00:00

abstract：:Introduction: The proteasome is a multi-subunit enzyme complex responsible for the turnover of short-lived, abnormal or damaged proteins in eukaryotic cells. As organisms that undergo rapid growth and cell division, protozoan parasites exist on the knife-edge of proteotoxic catastrophe and thus rely heavily on their p...

journal_title：Expert opinion on therapeutic targets

authors： Xie SC,Dick LR,Gould A,Brand S,Tilley L

更新日期：2019-11-01 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) has been widely shown to be associated with the development and progression of cancer. Recent studies discovered a handful of miRNAs with great potential to act as therapeutic targets in various human cancers. Inhibition or overexpression of these oncomirs may regulate the expressio...

journal_title：Expert opinion on therapeutic targets

authors： Cho WC

更新日期：2012-04-01 00:00:00

abstract：INTRODUCTION:Melanoma expresses both neurokinin-1 (NK-1) receptors and substance P (SP). After binding to the NK-1 receptor, SP induces tumor cell proliferation in melanoma cells, whereas after binding to the same NK-1 receptor, antagonists inhibit melanoma cell proliferation and cause tumor cell death by apoptosis. Th...

journal_title：Expert opinion on therapeutic targets

authors： Muñoz M,Bernabeu-Wittel J,Coveñas R

更新日期：2011-07-01 00:00:00

abstract：INTRODUCTION:Leptin is a hormone with a key role in food intake and body weight homeostasis. Congenital leptin deficiency (CLD) is a rare disease that causes hyperphagia and early severe obesity. However, common obesity conditions are associated with hyperleptinemia and leptin resistance. AREAS COVERED:The main signal...

journal_title：Expert opinion on therapeutic targets

authors： Sáinz N,González-Navarro CJ,Martínez JA,Moreno-Aliaga MJ

更新日期：2015-07-01 00:00:00

abstract：:IL-19, IL-20 and IL-24 are members of the IL-10 family of cytokines, the human IL-19, IL-20 and IL-24 genes are all located on the q32 region of chromosome 1, and the three cytokines also share a common receptor IL-20R1/IL-20R2 heterodimer. These cytokines due to the similarity and shared receptor usage, are quite ove...

journal_title：Expert opinion on therapeutic targets

authors： Leng RX,Pan HF,Tao JH,Ye DQ

更新日期：2011-02-01 00:00:00

abstract：INTRODUCTION:Systemic chemotherapy is a curative approach to inhibit gastric cancer cells proliferation. Despite the great progress in anti-cancer treatment achieved during the last decades, drug resistance and treatment refractoriness still extensively persists. Recently, accumulating studies have highlighted the role...

journal_title：Expert opinion on therapeutic targets

authors： Yang W,Ma J,Zhou W,Cao B,Zhou X,Yang Z,Zhang H,Zhao Q,Fan D,Hong L

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Adenosine receptors (ARs) and their differential pattern of expression modulate a series of pleiotropic activities that are known to contribute to the control of inflammation, remodeling, and tissue repair. Consequently, pharmacological manipulation of adenosine signaling pathway is of great interest and i...

journal_title：Expert opinion on therapeutic targets

authors： Caruso M,Alamo A,Crisafulli E,Raciti C,Fisichella A,Polosa R

更新日期：2013-07-01 00:00:00

abstract：:Cortistatin (CST) is a recently discovered neuropeptide from the somatostatin gene family, named after its predominantly cortical expression and ability to depress cortical activity. CST shows many remarkable structural and functional similarities to its related neuropeptide somatostatin, or somatotropin release-inhib...

journal_title：Expert opinion on therapeutic targets

authors： Rubio A,Avila J,de Lecea L

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Strategies for development of anti-parasite chemotherapy involve identification of active principles of plants, investigation of drugs already licensed for other pathologies, or validation of specific targets identified within key metabolic pathways. OBJECTIVE:To review the state of the art of drug targets ...

journal_title：Expert opinion on therapeutic targets

authors： Soeiro MN,de Castro SL

更新日期：2009-01-01 00:00:00

abstract：:Introduction: Epilepsy is a network-level neurological disorder characterized by unprovoked recurrent seizures and associated comorbidities. Aberrant activity and localization of histone deacetylases (HDACs) have been reported in epilepsy and HDAC inhibitors (HDACi) have been used for therapeutic purposes. Several non...

journal_title：Expert opinion on therapeutic targets

authors： Kumar S,Attrish D,Srivastava A,Banerjee J,Tripathi M,Chandra PS,Dixit AB

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION:Emerging evidence demonstrates that the high mobility group A1 (HMGA1) chromatin remodeling protein is a key molecular switch required by cancer cells for tumor progression and a poorly differentiated, stem-like state. Because the HMGA1 gene and proteins are expressed at high levels in all aggressive tumor...

journal_title：Expert opinion on therapeutic targets

authors： Huso TH,Resar LM

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Expression of synuclein-gamma (SNCG) protein is elevated in the advanced stages of many types of cancers, including ovarian, lung, liver, esophagus, colon, prostate and, in particular, breast. In breast carcinoma, SNCG is causatively linked to stimulated proliferation, metastasis and drug resistance. OBJECT...

journal_title：Expert opinion on therapeutic targets

authors： Singh VK,Jia Z

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:The co-inhibitory receptor programmed death 1 (PD-1) and its ligands are key regulators in a wide spectrum of immune responses and play a critical role in autoimmunity and self-tolerance as well as in cancer immunology. Emerging evidence suggests that cancer cells might use the PD-1/PD-ligand (PD-L) pathwa...

journal_title：Expert opinion on therapeutic targets

authors： Muenst S,Soysal SD,Tzankov A,Hoeller S

更新日期：2015-02-01 00:00:00

abstract：:The accumulation of malfolded proteins in the endoplasmic reticulum (ER) induces ER stress, leading to the disturbance of ER function. To restore ER function and ER homeostasis, cells possess a highly specific ER quality control system termed the unfolded protein response (UPR), which increases the capacity of protein...

journal_title：Expert opinion on therapeutic targets

authors： Homma K,Katagiri K,Nishitoh H,Ichijo H

更新日期：2009-06-01 00:00:00

abstract：INTRODUCTION:Adipocytes, which represent a substantial part of the tumor microenvironment in breast cancer, secrete several adipokines that affect tumorigenesis, cancer progression, metastasis, and treatment resistance via multiple signaling pathways. Areas covered: In this review, we focus on the role of leptin, adipo...

journal_title：Expert opinion on therapeutic targets

authors： Cha YJ,Koo JS

更新日期：2018-11-01 00:00:00

abstract：:Asthma, a chronic disease increasing in prevalence worldwide, is characterised by reversible airway obstruction, airway inflammation and airway smooth muscle (ASM) cell hyperplasia. The traditional view of ASM in asthma, as a regulator of bronchomotor tone, is rapidly changing. New evidence suggests that ASM cells als...

journal_title：Expert opinion on therapeutic targets

authors： Lazaar AL

更新日期：2002-08-01 00:00:00

abstract：:Introduction: Cholangiocarcinoma (CCA) is a rare, deadly cancer that is characterized by an abundant desmoplastic stroma. Late diagnoses and limited available effective treatments are major problems with this malignancy. Targeting of the tumor microenvironment (TME) has emerged as a potential therapeutic strategy. Are...

journal_title：Expert opinion on therapeutic targets

authors： Louis C,Edeline J,Coulouarn C

更新日期：2021-01-27 00:00:00

abstract：:Cardiovascular diseases (CVD) are the number one killer in the USA and are likely to be a significant cause of mortality in developing countries in the near future. High levels of high-density lipoprotein (HDL) are known to be inversely related to CVD incidence. However, whether or not HDL plays a direct preventative ...

journal_title：Expert opinion on therapeutic targets

authors： Davidson WS

更新日期：2004-08-01 00:00:00

abstract：:Filoviruses are filamentous lipid-enveloped viruses and include Ebola (EBOV) and Marburg, which are morphologically identical but antigenically distinct. These viruses can be very deadly with outbreaks of EBOV having clinical fatality as high as 90%. In 2012 there were two separate Ebola outbreaks in the Democratic Re...

journal_title：Expert opinion on therapeutic targets

authors： Stahelin RV

更新日期：2014-02-01 00:00:00

abstract：:In contrast to genetic aberrations, epigenetic aberrations can be reversed by the use of histone acetyltransferase (HAT), histone deacetylase (HDAC), SIRT, or histone methyltransferase (HMT) inhibitors. A well-known HDACi, suberoylanilide hydroxamic acid, has been recently approved for the treatment of cutaneous T cel...

journal_title：Expert opinion on therapeutic targets

authors： Mai A

更新日期：2007-06-01 00:00:00

abstract：INTRODUCTION:Nuclear factor TDP-43 is a ubiquitously expressed RNA binding protein that plays a key causative role in several neurodegenerative diseases, especially in the ALS/FTD spectrum. In addition, its aberrant aggregation and expression has been recently observed in other type of diseases, such as myopathies and ...

journal_title：Expert opinion on therapeutic targets

authors： Buratti E

更新日期：2018-03-01 00:00:00

abstract：INTRODUCTION:The common predominant clinical features of cholangiopathies such as primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), and biliary atresia (BA) are biliary damage/senescence and liver fibrosis. Curative therapies are lacking, and liver transplantation is the only option. An understan...

journal_title：Expert opinion on therapeutic targets

authors： Sato K,Glaser S,Kennedy L,Liangpunsakul S,Meng F,Francis H,Alpini G

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:Glycemic control is important in diabetes mellitus to minimize the progression of the disease and the risk of potentially devastating complications. Inhibition of the sodium-glucose cotransporter SGLT2 induces glucosuria and has been established as a new anti-hyperglycemic strategy. SGLT1 plays a distinct ...

journal_title：Expert opinion on therapeutic targets

authors： Song P,Onishi A,Koepsell H,Vallon V

更新日期：2016-09-01 00:00:00

abstract：:Traditional measures for treating metastatic cancer involve identification of the originating organ from which the neoplasm arose and empirical treatment with cytotoxic chemotherapy. Arguably, with the exception of haematological malignancies, demonstration of efficacy in solid tumours has been limited. Over the past ...

journal_title：Expert opinion on therapeutic targets

authors： Senzer N,Shen Y,Hill C,Nemunaitis J

更新日期：2005-12-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of trophic factors. BDNF is widely and abundantly expressed in the CNS and is available to some peripheral nervous system neurons that uptake the neurotrophin produced by peripheral tissues. BDNF promotes survival and differentiation of certai...

journal_title：Expert opinion on therapeutic targets

authors： Pezet S,Malcangio M

更新日期：2004-10-01 00:00:00

abstract：:Penile erection is a complex event controlled by vascular, hormonal and neuronal systems. The neuronal system involved in erection is often divided into spinal and supraspinal networks. It is generally accepted that the spinal system directly controls erection and that the supraspinal network modulates this control me...

journal_title：Expert opinion on therapeutic targets

authors： Temel Y,Hafizi S,Beuls E,Visser-Vandewalle V

更新日期：2005-10-01 00:00:00

abstract：:Gene expression profiling studies have classified breast cancer into five intrinsic subtypes with distinct prognostic significance: luminal type A, luminal type B, normal-like, HER-2-positive and basal type. These studies have also uncovered novel diagnostic markers and molecular targets. FOXA1, a winged-helix transcr...

journal_title：Expert opinion on therapeutic targets

authors： Nakshatri H,Badve S

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Autophagy is a major degradative and highly conserved process in eukaryotic cells that is activated by stress signals. This self-cannibalisation is activated as a response to changing environmental conditions, cellular remodelling during development and differentiation, and maintenance of homeostasis. OBJEC...

journal_title：Expert opinion on therapeutic targets

authors： Halapas A,Armakolas A,Koutsilieris M

更新日期：2008-12-01 00:00:00

abstract：:The transient receptor potential vanilloid 1 receptor (TRPV1) plays an important role in inflammatory heat hyperalgesia. TRPV1 is a non-selective cation channel gated by noxious heat, protons and capsaicin, thus being regarded as a polymodal molecular integrator in nociception. Abundant evidence has demonstrated that ...

journal_title：Expert opinion on therapeutic targets

authors： Ma W,Quirion R

更新日期：2007-03-01 00:00:00