Cortistatin as a therapeutic target in inflammation.


:Cortistatin (CST) is a recently discovered neuropeptide from the somatostatin gene family, named after its predominantly cortical expression and ability to depress cortical activity. CST shows many remarkable structural and functional similarities to its related neuropeptide somatostatin, or somatotropin release-inhibiting factor. However, the many physiological differences between CST and somatostatin are just as remarkable as the similarities. CST-29 has recently been shown to prevent inflammation in rodent models for human diseases, raising novel therapeutic properties to this neuropeptide. In this review, the authors address a new possible role for CST in the immune system and evaluate the possible therapeutic use of CST to treat disorders associated with inflammation.


Rubio A,Avila J,de Lecea L




Has Abstract


2007-01-01 00:00:00












  • Preclinical insights into cholangiopathies: disease modeling and emerging therapeutic targets.

    abstract:INTRODUCTION:The common predominant clinical features of cholangiopathies such as primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), and biliary atresia (BA) are biliary damage/senescence and liver fibrosis. Curative therapies are lacking, and liver transplantation is the only option. An understan...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Sato K,Glaser S,Kennedy L,Liangpunsakul S,Meng F,Francis H,Alpini G

    更新日期:2019-06-01 00:00:00

  • Quinone reductase 2 as a promising target of melatonin therapeutic actions.

    abstract:INTRODUCTION:The neurohormone melatonin is secreted by the pineal gland and shows a circadian rhythm. It has been used in pathological conditions to evaluate its protective capacity against disease, often in connection to oxidative stress. The abundance of cases reported suggests that the mechanisms of action through w...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Boutin JA

    更新日期:2016-01-01 00:00:00

  • HIV-1 entry inhibitors: closing the front door.

    abstract::Highly active antiretroviral therapy (HAART) has led to major declines in morbidity and mortality of HIV-1-infected individuals, but the increasing prevalence of drug-resistant viral isolates, combined with the toxicity and other limitations of current treatments, make the development of new therapies a high priority....

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Tomkowicz B,Collman RG

    更新日期:2004-04-01 00:00:00

  • Leptin signaling as a therapeutic target of obesity.

    abstract:INTRODUCTION:Leptin is a hormone with a key role in food intake and body weight homeostasis. Congenital leptin deficiency (CLD) is a rare disease that causes hyperphagia and early severe obesity. However, common obesity conditions are associated with hyperleptinemia and leptin resistance. AREAS COVERED:The main signal...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Sáinz N,González-Navarro CJ,Martínez JA,Moreno-Aliaga MJ

    更新日期:2015-07-01 00:00:00

  • Metalloproteinases: their role in arthritis and potential as therapeutic targets.

    abstract::Irreversible degradation of articular cartilage is a major feature of the arthritides, and its prevention is a therapeutic goal which has been difficult to achieve. Enzymes from the matrix metalloproteinase and ADAMTS (a disintegrin, a metalloproteinase, and thrombospondin motif) families are key mediators of cartilag...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Clark IM,Parker AE

    更新日期:2003-02-01 00:00:00

  • Adenosine signaling pathways as potential therapeutic targets in respiratory disease.

    abstract:INTRODUCTION:Adenosine receptors (ARs) and their differential pattern of expression modulate a series of pleiotropic activities that are known to contribute to the control of inflammation, remodeling, and tissue repair. Consequently, pharmacological manipulation of adenosine signaling pathway is of great interest and i...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Caruso M,Alamo A,Crisafulli E,Raciti C,Fisichella A,Polosa R

    更新日期:2013-07-01 00:00:00

  • Targeting RNA polymerase I transcription and the nucleolus for cancer therapy.

    abstract::The nucleoli are the site of the production of ribosomes, the protein synthetic apparatus of the cell. The presence of enlarged nucleoli, reflecting increased ribosomal gene transcription, has long been used by pathologists as an indicator of aggressive tumors. However, over the last 10 years a growing body of evidenc...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 社论


    authors: Hannan RD,Drygin D,Pearson RB

    更新日期:2013-08-01 00:00:00

  • Targeting ASK1 in ER stress-related neurodegenerative diseases.

    abstract::The accumulation of malfolded proteins in the endoplasmic reticulum (ER) induces ER stress, leading to the disturbance of ER function. To restore ER function and ER homeostasis, cells possess a highly specific ER quality control system termed the unfolded protein response (UPR), which increases the capacity of protein...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Homma K,Katagiri K,Nishitoh H,Ichijo H

    更新日期:2009-06-01 00:00:00

  • Established and emerging vascular risk factors and the development of aortic stenosis: an opportunity for prevention?

    abstract:BACKGROUND:Aortic stenosis (AS) is the commonest valvular heart disease in the developed world. It is becoming increasingly accepted that the pathogenesis of AS and of its preceding abnormalities, aortic valve sclerosis (AVS) and aortic valve calcification (AVC), shares many characteristics with the atherosclerotic pro...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Tziomalos K,Athyros VG,Karagiannis A,Mikhailidis DP

    更新日期:2008-07-01 00:00:00

  • HtrA proteins as targets in therapy of cancer and other diseases.

    abstract:IMPORTANCE OF THE FIELD:The HtrA family proteins are serine proteases that are involved in important physiological processes, including maintenance of mitochondrial homeostasis, apoptosis and cell signaling. They are involved in the development and progression of several pathological processes such as cancer, neurodege...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Zurawa-Janicka D,Skorko-Glonek J,Lipinska B

    更新日期:2010-07-01 00:00:00

  • Targeting RhoA/ROCK pathway in pulmonary arterial hypertension.

    abstract:INTRODUCTION:Pulmonary arterial hypertension (PAH) is a rare disease with a complex pathogenesis. It is often associated with an increased vascular resistance, whilst in the more advanced stages there is a remodelling of the vascular walls. PAH has an intricate involvement of various signaling pathways, including the r...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Antoniu SA

    更新日期:2012-04-01 00:00:00

  • Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma.

    abstract:OBJECTIVE:HDAC inhibitors (HDI) are anti-neoplastic drugs with preliminary successful clinical applications in Hodgkin's lymphoma (HL). Systematic investigations of HDAC expression in HL, based on histology and immunohistochemistry are yet rare. RESEARCH DESIGN/METHODS:We investigated the expression of HDAC1, 2 and 3 ...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章


    authors: Adams H,Fritzsche FR,Dirnhofer S,Kristiansen G,Tzankov A

    更新日期:2010-06-01 00:00:00

  • Brain-derived neurotrophic factor as a drug target for CNS disorders.

    abstract::Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of trophic factors. BDNF is widely and abundantly expressed in the CNS and is available to some peripheral nervous system neurons that uptake the neurotrophin produced by peripheral tissues. BDNF promotes survival and differentiation of certai...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Pezet S,Malcangio M

    更新日期:2004-10-01 00:00:00

  • Targeting sigma-1 receptor signaling by endogenous ligands for cardioprotection.

    abstract:INTRODUCTION:The sigma receptors, initially described as a subtype of opioid receptors, are now considered to be a unique receptor expressed in neonatal rat cardiomyocytes and in the plasma membrane of adult rat cardiomyocytes. A number of sigma receptor ligands influence cardiovascular function and the heart has bindi...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Bhuiyan MS,Fukunaga K

    更新日期:2011-02-01 00:00:00

  • The potential for targeting HER2 therapeutically in esophageal cancer - a grasp at straws?

    abstract:INTRODUCTION:Human EGFR-2 (HER2) has an impact on cellular proliferation and survival. HER2 overexpression has been shown to be a marker for poorer prognosis in several malignancies. Trastuzumab, a humanized mAb, is successfully used to target HER2 in breast cancer. The effect of targeting HER2 in esophageal cancer (EC...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Uzunoglu FG,Koenig AM,Izbicki JR

    更新日期:2014-12-01 00:00:00

  • Functional proteomics to study protection of the ischaemic myocardium.

    abstract::Mechanisms to reduce the deleterious effects of myocardial ischaemia are of particular clinical importance and have been the focus of intense research for a number of years. Among novel approaches to studying the ischaemic heart, proteomics, or the analysis of all cellular proteins, presents as a powerful method to de...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Vondriska TM,Ping P

    更新日期:2002-10-01 00:00:00

  • Targeting cancer stem cells.

    abstract::Recent evidence has demonstrated the existence of a small subset of the tumour mass that is wholly responsible for the sustained growth and propagation of the tumour. This cancer stem cell (CSC) compartment is also likely to be responsible both for disease relapse and the resistance to therapy that often accompanies r...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Kvinlaug BT,Huntly BJ

    更新日期:2007-07-01 00:00:00

  • Type 3 deiodinase and solid tumors: an intriguing pair.

    abstract:INTRODUCTION:Thyroid hormone (TH) metabolism is mediated by deiodinases, a family of thioredoxin fold-containing enzymes that remove iodide from thyroxine and its derivatives. The coordinated action of deiodinases allows target cells to modulate rapidly their own TH availability in response to different cues. Type 3 de...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Dentice M,Antonini D,Salvatore D

    更新日期:2013-11-01 00:00:00

  • Targeted therapy for epithelial ovarian cancer.

    abstract::Ovarian cancer is the leading cause of death in women with gynecological malignancies and overall survival for patients with advanced epithelial ovarian cancer (EOC) remains poor. The majority of patients recur after initial treatment. A strategy for improving outcome is to minimise recurrence via targeted therapy in ...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Sharma S,Odunsi K

    更新日期:2005-06-01 00:00:00

  • Steroid receptor coactivator-3 as a potential molecular target for cancer therapy.

    abstract:INTRODUCTION:Steroid receptor coactivator-3 (SRC-3), also called amplified-in-breast cancer-1 (AIB1), is an oncogenic coactivator in endocrine and non-endocrine cancers. Functional studies demonstrate SRC-3 promotes numerous aspects of cancer, through its capacity as a coactivator for nuclear hormone receptors and othe...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Tien JC,Xu J

    更新日期:2012-11-01 00:00:00

  • Wnt signaling as a therapeutic target for bone diseases.

    abstract:BACKGROUND:There is a need to develop new bone anabolic agents because current bone regeneration regimens have limitations. The Wingless-type MMTV integration site (Wnt) pathway has emerged as a regulator of bone formation and regeneration. OBJECTIVE:To review the molecular basis for Wnt pathway modulation and discuss...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Hoeppner LH,Secreto FJ,Westendorf JJ

    更新日期:2009-04-01 00:00:00

  • An overview of the mTOR pathway as a target in cancer therapy.

    abstract:INTRODUCTION:The mammalian target of rapamycin (mTOR) signaling cascade is a key regulatory pathway controlling initiation of mRNA translation in mammalian cells. The mTOR inhibitor rapamycin and its derivatives have shown potent antineoplastic activities in many preclinical models and clinical trials. First-generation...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Gentzler RD,Altman JK,Platanias LC

    更新日期:2012-05-01 00:00:00

  • New developments in the urokinase-type plasminogen activator system.

    abstract::The urokinase-type plasminogen activator (uPA) system plays a central role in control of cell surface proteolysis and extracellular matrix degradation. Components of this system are upregulated in a wide variety of human cancers and high levels of these proteins predict more rapid relapse and shorter survival. Recentl...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章


    authors: Rosenberg S

    更新日期:2001-12-01 00:00:00

  • RNA interference screening for the discovery of oncology targets.

    abstract::RNA interference (RNAi) mediated loss-of-function screens have the potential to delineate biological functions of genes and the proteins they encode. RNAi has proven to be a promising technology for identification and validation of new targets for the pharmacological treatment of many diseases including cancer. Here w...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Quon K,Kassner PD

    更新日期:2009-09-01 00:00:00

  • Targeting mitochondrial quality control for treating sarcopenia: lessons from physical exercise.

    abstract:INTRODUCTION:Mitochondrial dysfunction is a hallmark of aging and hence is a candidate target for intervention. Sarcopenia of aging is a prevalent condition and is associated with numerous negative health outcomes. Alterations in mitochondrial homeostasis have been reported in sarcopenic muscle. Area covered: We discus...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Picca A,Calvani R,Leeuwenburgh C,Coelho-Junior HJ,Bernabei R,Landi F,Marzetti E

    更新日期:2019-02-01 00:00:00

  • Non-histone substrates of histone deacetylases as potential therapeutic targets in epilepsy.

    abstract::Introduction: Epilepsy is a network-level neurological disorder characterized by unprovoked recurrent seizures and associated comorbidities. Aberrant activity and localization of histone deacetylases (HDACs) have been reported in epilepsy and HDAC inhibitors (HDACi) have been used for therapeutic purposes. Several non...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章


    authors: Kumar S,Attrish D,Srivastava A,Banerjee J,Tripathi M,Chandra PS,Dixit AB

    更新日期:2021-01-01 00:00:00

  • Targeting the EGFR T790M mutation in non-small-cell lung cancer.

    abstract:INTRODUCTION:The presence of activating mutations of the epidermal growth factor receptor (EGFR) is predictive of response to first- and second-generation tyrosine kinase inhibitors (TKIs) in patients with advanced non-small-cell lung cancer (NSCLC). However, patients that initially respond to these drugs inexorably be...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Normanno N,Maiello MR,Chicchinelli N,Iannaccone A,Esposito C,De Cecio R,D'alessio A,De Luca A

    更新日期:2017-02-01 00:00:00

  • The ATPases: a new family for a family-based drug design approach.

    abstract::The rapid discovery of new drugs is greatly facilitated when a family of related proteins is targeted with a similar approach in chemistry. Few protein families have so far been investigated using this kind of 'family-based' approach. Therefore, to increase the size of our Pharmacopeia and to cure human diseases more ...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Chène P

    更新日期:2003-06-01 00:00:00

  • Airway smooth muscle: new targets for asthma pharmacotherapy.

    abstract::Asthma, a chronic disease increasing in prevalence worldwide, is characterised by reversible airway obstruction, airway inflammation and airway smooth muscle (ASM) cell hyperplasia. The traditional view of ASM in asthma, as a regulator of bronchomotor tone, is rapidly changing. New evidence suggests that ASM cells als...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Lazaar AL

    更新日期:2002-08-01 00:00:00

  • Selective Raf inhibition in cancer therapy.

    abstract::Over the past 5 years, the Raf kinase family has emerged as a promising target for protein-directed cancer therapy development. The goal of this review is to first provide a concise summary of the data validating Raf proteins as high-interest therapeutic targets. The authors then outline the mode of action of Raf kina...

    journal_title:Expert opinion on therapeutic targets

    pub_type: 杂志文章,评审


    authors: Khazak V,Astsaturov I,Serebriiskii IG,Golemis EA

    更新日期:2007-12-01 00:00:00