Cortistatin as a therapeutic target in inflammation.

abstract：INTRODUCTION:The common predominant clinical features of cholangiopathies such as primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), and biliary atresia (BA) are biliary damage/senescence and liver fibrosis. Curative therapies are lacking, and liver transplantation is the only option. An understan...

journal_title：Expert opinion on therapeutic targets

authors： Sato K,Glaser S,Kennedy L,Liangpunsakul S,Meng F,Francis H,Alpini G

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:The neurohormone melatonin is secreted by the pineal gland and shows a circadian rhythm. It has been used in pathological conditions to evaluate its protective capacity against disease, often in connection to oxidative stress. The abundance of cases reported suggests that the mechanisms of action through w...

journal_title：Expert opinion on therapeutic targets

authors： Boutin JA

更新日期：2016-01-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) has led to major declines in morbidity and mortality of HIV-1-infected individuals, but the increasing prevalence of drug-resistant viral isolates, combined with the toxicity and other limitations of current treatments, make the development of new therapies a high priority....

journal_title：Expert opinion on therapeutic targets

authors： Tomkowicz B,Collman RG

更新日期：2004-04-01 00:00:00

abstract：INTRODUCTION:Leptin is a hormone with a key role in food intake and body weight homeostasis. Congenital leptin deficiency (CLD) is a rare disease that causes hyperphagia and early severe obesity. However, common obesity conditions are associated with hyperleptinemia and leptin resistance. AREAS COVERED:The main signal...

journal_title：Expert opinion on therapeutic targets

authors： Sáinz N,González-Navarro CJ,Martínez JA,Moreno-Aliaga MJ

更新日期：2015-07-01 00:00:00

abstract：:Irreversible degradation of articular cartilage is a major feature of the arthritides, and its prevention is a therapeutic goal which has been difficult to achieve. Enzymes from the matrix metalloproteinase and ADAMTS (a disintegrin, a metalloproteinase, and thrombospondin motif) families are key mediators of cartilag...

journal_title：Expert opinion on therapeutic targets

authors： Clark IM,Parker AE

更新日期：2003-02-01 00:00:00

abstract：INTRODUCTION:Adenosine receptors (ARs) and their differential pattern of expression modulate a series of pleiotropic activities that are known to contribute to the control of inflammation, remodeling, and tissue repair. Consequently, pharmacological manipulation of adenosine signaling pathway is of great interest and i...

journal_title：Expert opinion on therapeutic targets

authors： Caruso M,Alamo A,Crisafulli E,Raciti C,Fisichella A,Polosa R

更新日期：2013-07-01 00:00:00

abstract：:The nucleoli are the site of the production of ribosomes, the protein synthetic apparatus of the cell. The presence of enlarged nucleoli, reflecting increased ribosomal gene transcription, has long been used by pathologists as an indicator of aggressive tumors. However, over the last 10 years a growing body of evidenc...

journal_title：Expert opinion on therapeutic targets

authors： Hannan RD,Drygin D,Pearson RB

更新日期：2013-08-01 00:00:00

abstract：:The accumulation of malfolded proteins in the endoplasmic reticulum (ER) induces ER stress, leading to the disturbance of ER function. To restore ER function and ER homeostasis, cells possess a highly specific ER quality control system termed the unfolded protein response (UPR), which increases the capacity of protein...

journal_title：Expert opinion on therapeutic targets

authors： Homma K,Katagiri K,Nishitoh H,Ichijo H

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Aortic stenosis (AS) is the commonest valvular heart disease in the developed world. It is becoming increasingly accepted that the pathogenesis of AS and of its preceding abnormalities, aortic valve sclerosis (AVS) and aortic valve calcification (AVC), shares many characteristics with the atherosclerotic pro...

journal_title：Expert opinion on therapeutic targets

authors： Tziomalos K,Athyros VG,Karagiannis A,Mikhailidis DP

更新日期：2008-07-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:The HtrA family proteins are serine proteases that are involved in important physiological processes, including maintenance of mitochondrial homeostasis, apoptosis and cell signaling. They are involved in the development and progression of several pathological processes such as cancer, neurodege...

journal_title：Expert opinion on therapeutic targets

authors： Zurawa-Janicka D,Skorko-Glonek J,Lipinska B

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:Pulmonary arterial hypertension (PAH) is a rare disease with a complex pathogenesis. It is often associated with an increased vascular resistance, whilst in the more advanced stages there is a remodelling of the vascular walls. PAH has an intricate involvement of various signaling pathways, including the r...

journal_title：Expert opinion on therapeutic targets

authors： Antoniu SA

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:HDAC inhibitors (HDI) are anti-neoplastic drugs with preliminary successful clinical applications in Hodgkin's lymphoma (HL). Systematic investigations of HDAC expression in HL, based on histology and immunohistochemistry are yet rare. RESEARCH DESIGN/METHODS:We investigated the expression of HDAC1, 2 and 3 ...

journal_title：Expert opinion on therapeutic targets

authors： Adams H,Fritzsche FR,Dirnhofer S,Kristiansen G,Tzankov A

更新日期：2010-06-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of trophic factors. BDNF is widely and abundantly expressed in the CNS and is available to some peripheral nervous system neurons that uptake the neurotrophin produced by peripheral tissues. BDNF promotes survival and differentiation of certai...

journal_title：Expert opinion on therapeutic targets

authors： Pezet S,Malcangio M

更新日期：2004-10-01 00:00:00

abstract：INTRODUCTION:The sigma receptors, initially described as a subtype of opioid receptors, are now considered to be a unique receptor expressed in neonatal rat cardiomyocytes and in the plasma membrane of adult rat cardiomyocytes. A number of sigma receptor ligands influence cardiovascular function and the heart has bindi...

journal_title：Expert opinion on therapeutic targets

authors： Bhuiyan MS,Fukunaga K

更新日期：2011-02-01 00:00:00

abstract：INTRODUCTION:Human EGFR-2 (HER2) has an impact on cellular proliferation and survival. HER2 overexpression has been shown to be a marker for poorer prognosis in several malignancies. Trastuzumab, a humanized mAb, is successfully used to target HER2 in breast cancer. The effect of targeting HER2 in esophageal cancer (EC...

journal_title：Expert opinion on therapeutic targets

authors： Uzunoglu FG,Koenig AM,Izbicki JR

更新日期：2014-12-01 00:00:00

abstract：:Mechanisms to reduce the deleterious effects of myocardial ischaemia are of particular clinical importance and have been the focus of intense research for a number of years. Among novel approaches to studying the ischaemic heart, proteomics, or the analysis of all cellular proteins, presents as a powerful method to de...

journal_title：Expert opinion on therapeutic targets

authors： Vondriska TM,Ping P

更新日期：2002-10-01 00:00:00

abstract：:Recent evidence has demonstrated the existence of a small subset of the tumour mass that is wholly responsible for the sustained growth and propagation of the tumour. This cancer stem cell (CSC) compartment is also likely to be responsible both for disease relapse and the resistance to therapy that often accompanies r...

journal_title：Expert opinion on therapeutic targets

authors： Kvinlaug BT,Huntly BJ

更新日期：2007-07-01 00:00:00

abstract：INTRODUCTION:Thyroid hormone (TH) metabolism is mediated by deiodinases, a family of thioredoxin fold-containing enzymes that remove iodide from thyroxine and its derivatives. The coordinated action of deiodinases allows target cells to modulate rapidly their own TH availability in response to different cues. Type 3 de...

journal_title：Expert opinion on therapeutic targets

authors： Dentice M,Antonini D,Salvatore D

更新日期：2013-11-01 00:00:00

abstract：:Ovarian cancer is the leading cause of death in women with gynecological malignancies and overall survival for patients with advanced epithelial ovarian cancer (EOC) remains poor. The majority of patients recur after initial treatment. A strategy for improving outcome is to minimise recurrence via targeted therapy in ...

journal_title：Expert opinion on therapeutic targets

authors： Sharma S,Odunsi K

更新日期：2005-06-01 00:00:00

abstract：INTRODUCTION:Steroid receptor coactivator-3 (SRC-3), also called amplified-in-breast cancer-1 (AIB1), is an oncogenic coactivator in endocrine and non-endocrine cancers. Functional studies demonstrate SRC-3 promotes numerous aspects of cancer, through its capacity as a coactivator for nuclear hormone receptors and othe...

journal_title：Expert opinion on therapeutic targets

authors： Tien JC,Xu J

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:There is a need to develop new bone anabolic agents because current bone regeneration regimens have limitations. The Wingless-type MMTV integration site (Wnt) pathway has emerged as a regulator of bone formation and regeneration. OBJECTIVE:To review the molecular basis for Wnt pathway modulation and discuss...

journal_title：Expert opinion on therapeutic targets

authors： Hoeppner LH,Secreto FJ,Westendorf JJ

更新日期：2009-04-01 00:00:00

abstract：INTRODUCTION:The mammalian target of rapamycin (mTOR) signaling cascade is a key regulatory pathway controlling initiation of mRNA translation in mammalian cells. The mTOR inhibitor rapamycin and its derivatives have shown potent antineoplastic activities in many preclinical models and clinical trials. First-generation...

journal_title：Expert opinion on therapeutic targets

authors： Gentzler RD,Altman JK,Platanias LC

更新日期：2012-05-01 00:00:00

abstract：:The urokinase-type plasminogen activator (uPA) system plays a central role in control of cell surface proteolysis and extracellular matrix degradation. Components of this system are upregulated in a wide variety of human cancers and high levels of these proteins predict more rapid relapse and shorter survival. Recentl...

journal_title：Expert opinion on therapeutic targets

authors： Rosenberg S

更新日期：2001-12-01 00:00:00

abstract：:RNA interference (RNAi) mediated loss-of-function screens have the potential to delineate biological functions of genes and the proteins they encode. RNAi has proven to be a promising technology for identification and validation of new targets for the pharmacological treatment of many diseases including cancer. Here w...

journal_title：Expert opinion on therapeutic targets

authors： Quon K,Kassner PD

更新日期：2009-09-01 00:00:00

abstract：INTRODUCTION:Mitochondrial dysfunction is a hallmark of aging and hence is a candidate target for intervention. Sarcopenia of aging is a prevalent condition and is associated with numerous negative health outcomes. Alterations in mitochondrial homeostasis have been reported in sarcopenic muscle. Area covered: We discus...

journal_title：Expert opinion on therapeutic targets

authors： Picca A,Calvani R,Leeuwenburgh C,Coelho-Junior HJ,Bernabei R,Landi F,Marzetti E

更新日期：2019-02-01 00:00:00

abstract：:Introduction: Epilepsy is a network-level neurological disorder characterized by unprovoked recurrent seizures and associated comorbidities. Aberrant activity and localization of histone deacetylases (HDACs) have been reported in epilepsy and HDAC inhibitors (HDACi) have been used for therapeutic purposes. Several non...

journal_title：Expert opinion on therapeutic targets

authors： Kumar S,Attrish D,Srivastava A,Banerjee J,Tripathi M,Chandra PS,Dixit AB

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION:The presence of activating mutations of the epidermal growth factor receptor (EGFR) is predictive of response to first- and second-generation tyrosine kinase inhibitors (TKIs) in patients with advanced non-small-cell lung cancer (NSCLC). However, patients that initially respond to these drugs inexorably be...

journal_title：Expert opinion on therapeutic targets

authors： Normanno N,Maiello MR,Chicchinelli N,Iannaccone A,Esposito C,De Cecio R,D'alessio A,De Luca A

更新日期：2017-02-01 00:00:00

abstract：:The rapid discovery of new drugs is greatly facilitated when a family of related proteins is targeted with a similar approach in chemistry. Few protein families have so far been investigated using this kind of 'family-based' approach. Therefore, to increase the size of our Pharmacopeia and to cure human diseases more ...

journal_title：Expert opinion on therapeutic targets

authors： Chène P

更新日期：2003-06-01 00:00:00

abstract：:Asthma, a chronic disease increasing in prevalence worldwide, is characterised by reversible airway obstruction, airway inflammation and airway smooth muscle (ASM) cell hyperplasia. The traditional view of ASM in asthma, as a regulator of bronchomotor tone, is rapidly changing. New evidence suggests that ASM cells als...

journal_title：Expert opinion on therapeutic targets

authors： Lazaar AL

更新日期：2002-08-01 00:00:00

abstract：:Over the past 5 years, the Raf kinase family has emerged as a promising target for protein-directed cancer therapy development. The goal of this review is to first provide a concise summary of the data validating Raf proteins as high-interest therapeutic targets. The authors then outline the mode of action of Raf kina...

journal_title：Expert opinion on therapeutic targets

authors： Khazak V,Astsaturov I,Serebriiskii IG,Golemis EA

更新日期：2007-12-01 00:00:00