Abstract：
:In order to colonize a niche and compete for scarce resources, microorganisms have evolved means to adjust the expression levels of their biosynthetic enzymes in response to the changing levels of metabolites available to them. To do so, they often rely on transcription factors or structured RNAs that directly sense the concentration of metabolites and turn genes on or off accordingly. In some instances, however, a metabolite can be sensed by an actively translating ribosome bearing a nascent polypeptide whose specific amino acid sequence interferes with translation. These “arrest peptides” lead to the formation of stalled ribosome nascent chain complexes on the mRNA that can regulate the expression of downstream genes through transcriptional or translational mechanisms. Although this process was discovered over three and a half decades ago, the extent to which arrest peptides regulate gene expression in response to cell metabolites is unknown. Here, we examine the physical constraints imposed by the ribosome on peptide-mediated ligand sensing and review attempts to assess the diversity of arrest peptides to date. In addition, we outline a possible way forward to establish how pervasive metabolite sensing by arrest peptides is in nature.
journal_name
J Mol Bioljournal_title
Journal of molecular biologyauthors
Seip B,Innis CAdoi
10.1016/j.jmb.2016.04.019subject
Has Abstractpub_date
2016-05-22 00:00:00pages
2217-27issue
10 Pt Beissn
0022-2836issn
1089-8638pii
S0022-2836(16)30078-Xjournal_volume
428pub_type
杂志文章,评审abstract：:Human prostate-specific antigen (PSA or KLK3) is an important marker for the diagnosis and management of prostate cancer. This is an androgen-regulated glycoprotein of the kallikrein-related protease family secreted by prostatic epithelial cells. Its physiological function is to cleave semenogelins in the seminal coag...
journal_title：Journal of molecular biology
pub_type： 杂志文章
doi：10.1016/j.jmb.2007.11.052
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abstract：:Huntington's disease (HD) is an inherited progressive neurodegenerative disorder caused by a pathological CAG trinucleotide repeat expansion in the large multi-exon gene, huntingtin (HTT). Although multiple pathogenic mechanisms have been proposed for HD, there is increasing interest in the RNA processing of the HTT g...
journal_title：Journal of molecular biology
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journal_title：Journal of molecular biology
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doi：10.1016/j.jmb.2011.08.005
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journal_title：Journal of molecular biology
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journal_title：Journal of molecular biology
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doi：10.1016/j.jmb.2006.12.010
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journal_title：Journal of molecular biology
pub_type： 杂志文章
doi：10.1016/j.jmb.2010.10.036
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pub_type： 杂志文章
doi：10.1016/j.jmb.2010.05.060
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journal_title：Journal of molecular biology
pub_type： 杂志文章
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更新日期：2017-10-13 00:00:00
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journal_title：Journal of molecular biology
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doi：10.1016/j.jmb.2009.12.023
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pub_type： 杂志文章
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更新日期：2003-01-24 00:00:00
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journal_title：Journal of molecular biology
pub_type： 杂志文章
doi：10.1016/j.jmb.2005.07.055
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journal_title：Journal of molecular biology
pub_type： 杂志文章
doi：10.1006/jmbi.1999.3071
更新日期：1999-09-24 00:00:00
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journal_title：Journal of molecular biology
pub_type： 杂志文章
doi：10.1006/jmbi.2000.4234
更新日期：2000-12-15 00:00:00
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journal_title：Journal of molecular biology
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doi：10.1016/s0022-2836(03)00834-9
更新日期：2003-08-22 00:00:00
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journal_title：Journal of molecular biology
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doi：10.1016/j.jmb.2006.02.043
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