Abstract:
STUDY DESIGN:The study was based on porcine posterolateral fusion model. OBJECTIVE:The study aims to prove that polyelectrolyte complex (PEC) carrier could enhance the efficacy and safety profile of bone morphogenetic protein-2 (BMP-2). SUMMARY OF BACKGROUND DATA:BMP-2 was introduced to enhance posterolateral fusion; however, extremely high doses of this molecule were often used which contributed to various complications. This was attributed to the poor modulation capacity of the traditional carrier absorbable collagen sponge (ACS). To reduce the efficacious dose of BMP-2 and its associated complications, heparin-based PEC was introduced. METHODS:L3/L4 and L5/L6 two-level posterolateral spinal fusion was performed on six pigs using two doses of BMP-2 with PEC or ACS: (1) PEC with 800 μg BMP-2 (n = 2); (2) PEC with 400 μg BMP-2 (n = 2); (3) ACS with 800 μg BMP-2 (n = 1); (4) ACS with 400 μg of BMP-2 (n = 1). The construct was loaded into a rigid bioabsorbable cage for implantation. Fusion rate and quality were assessed 2 months after operation. RESULTS:Manual palpation revealed successful fusion in all groups. Radiological fusion score of PEC groups was, however, higher than that of ACS groups. The newly formed bone in PEC groups appeared to be well integrated into the native bone with no overgrowth into the adjacent structure. On comparison, in ACS groups, large gaps were observed between the newly formed bone and the fusion bed with heterotopic ossification into the psoas muscle. The microarchitecture on the newly formed bone in PEC groups was superior to that in ACS groups, which was demonstrated by higher three-dimensional parameters. CONCLUSION:The present study demonstrated that BMP-2 delivered by PEC induced successful posterolateral fusion in porcine model. The efficacy of BMP-2 was improved and bony overgrowth was reduced. The microarchitecture of BMP-2-induced bone tissue was also enhanced by PEC. LEVEL OF EVIDENCE:N/A.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Wang M,Lam RWM,Abbah SA,Hu T,Toh SY,Cool S,Bhakoo K,Li J,Goh JCH,Wong HKdoi
10.1097/BRS.0000000000001543subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1199-1207issue
15eissn
0362-2436issn
1528-1159pii
00007632-201608010-00002journal_volume
41pub_type
杂志文章相关文献
SPINE文献大全abstract::A retrospective study was done to determine the entire clinical spectrum of lumbar spine disease in 47 adult patients, averaging 27.6 years of age, with achondroplasia. Five distinct clinical categories were defined. Twenty-eight percent of the patients were asymptomatic; 28% had only mechanical or degenerative lumbar...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198203000-00008
更新日期:1982-03-01 00:00:00
abstract::The ability of Elvey's "brachial plexus tension test" to identify pain referred from the cervical region was investigated in 50 patients with unilateral shoulder and upper arm pain: 25 reported symptoms commencing after open heart surgery, indicating a high probability of referred pain due to that procedure; 25 were a...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199401000-00006
更新日期:1994-01-01 00:00:00
abstract:STUDY DESIGN:In vivo animal study. OBJECTIVES:To describe a new porcine disc degeneration model, and to analyze disc remodeling and degeneration after nucleotomy with special view to the different nucleus pulposus (NP) cell types. SUMMARY OF BACKGROUND DATA:Thus far, predominantly smaller animals were used for disc d...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181b723c9
更新日期:2009-12-01 00:00:00
abstract::: This next issue of Evidence-Based Recommendations for Spine Surgery examines six articles that seek to address pressing and relevant issues in contemporary spine surgery. These articles explore the safety and efficacy of tranexamic acid during lumbar surgery, the utility of post-operative MRI after spinal decompress...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003512
更新日期:2020-06-15 00:00:00
abstract:STUDY DESIGN:Clinical study. OBJECTIVE:To investigate the feasibility of the transoral endoscopic odontoidectomy without occipitocervical fusion. SUMMARY OF BACKGROUND DATA:Endoscopic transnasal resection of the odontoid process is less invasive than the conventional transoral odontoidectomy. However, the endonasal a...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3182941735
更新日期:2013-06-15 00:00:00
abstract:STUDY DESIGN:Systematic review. OBJECTIVE:To determine the effects of acupuncture for individuals with neck pain. SUMMARY OF BACKGROUND DATA:Neck pain is one of the 3 most frequently reported complaints of the musculoskeletal system. Treatments for neck pain are varied, as are the perceptions of benefits. METHODS.: W...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/01.brs.0000252100.61002.d4
更新日期:2007-01-15 00:00:00
abstract:STUDY DESIGN:Retrospective study. OBJECTIVES:To report the results and the technique of posterior vertebral column resection (PVCR) in fixed lumbosacral deformity. SUMMARY OF BACKGROUND DATA:Fixed lumbosacral deformity has gross imbalance as well as progressive compensatory thoracolumbar deformity because of the abse...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000188190.90034.be
更新日期:2005-12-01 00:00:00
abstract:STUDY DESIGN:Cross-sectional survey. OBJECTIVE:The aim of this study was to investigate the impact of COVID-19 pandemic on the clinical practices of spine surgeons within the Asia Pacific region. SUMMARY OF BACKGROUND DATA:COVID-19 pandemic had changed spine surgeons' clinical practices and their concerns toward pers...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003622
更新日期:2020-09-15 00:00:00
abstract:STUDY DESIGN:This anatomic study tested placement of C2 pedicle screws using cadaver specimens. OBJECTIVES:To further assess the safety of transpedicular screw placement in the axis by comparing two surgical techniques. SUMMARY OF BACKGROUND DATA:Transpedicular screw fixation of traumatic spondylolisthesis of the axi...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199603150-00005
更新日期:1996-03-15 00:00:00
abstract:STUDY DESIGN:A radiographic, histologic, biochemical, and gene expression study was conducted in vivo in a rabbit model to determine the effect of injection of the N-terminal 30 kDa fibronectin fragment (Fn-f) into the intervertebral disc along with various control substances. OBJECTIVE:To determine if the Fn-f is abl...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.BRS.0000096943.27853.BC
更新日期:2003-10-15 00:00:00
abstract::The management of herniated lumbar intervertebral disc for patients not responding to an initial trial of conservative therapy is generally surgical. Little is known about the effect of continued conservative therapy on patients who have not improved or have deteriorated within the first 3 months. This study assessed ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199202000-00010
更新日期:1992-02-01 00:00:00
abstract::A patient with adult idiopathic scoliosis who was successfully treated with posterior spinal fusion with segmental instrumentation from T3 to L4 is presented. One year after surgery fractures of both L4 pedicles developed, which were managed nonoperatively. Clinical union was achieved in 2 months and the patient was f...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199307000-00016
更新日期:1993-07-01 00:00:00
abstract:STUDY DESIGN:A study on the efficacy of recombinant human bone morphogenetic protein 2 (rhBMP-2) in a nonhuman primate anterior interbody fusion model. OBJECTIVES:To investigate the efficacy of rhBMP-2 with an absorbable collagen sponge carrier to promote spinal fusion in a nonhuman primate anterior interbody fusion m...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199904010-00004
更新日期:1999-04-01 00:00:00
abstract:STUDY DESIGN:Cross-sectional study to evaluate the thoracic and lumbar spine in patients with diastrophic dysplasia (DD). OBJECTIVES:To find the causative factors behind the spinal deformities and restricted mobility of the spine. SUMMARY OF BACKGROUND DATA:Typical findings in this skeletal dysplasia are short-limbed...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200101150-00014
更新日期:2001-01-15 00:00:00
abstract:STUDY DESIGN:Eighteen patients with lumbar instability from fractures, postlaminectomy syndrome, or infection were treated prospectively with minimally invasive retroperitoneal lumbar fusions. OBJECTIVES:To determine if interbody Bagby and Kuslich fusion cages and femoral allograft bone dowels can be inserted in a tra...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199807010-00009
更新日期:1998-07-01 00:00:00
abstract:STUDY DESIGN:Validation study to define validity and reliability of an adapted and translated questionnaire. OBJECTIVE:Assessment of the concurrent validity and reliability of a Chinese version of SRS-22 outcome instrument. SUMMARY OF BACKGROUND DATA:No valid health-related quality of life (HRQL) outcome instrument e...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000261562.48888.e3
更新日期:2007-05-01 00:00:00
abstract::Radiographic instability seemingly enjoys the status of a well-defined clinical syndrome. The concept is widely used, and specific treatments, usually spinal fusion, are routinely performed based on the diagnosis. The minimum standards necessary to establish radiographic instability as a legitimate clinical syndrome h...
journal_title:Spine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007632-199310000-00020
更新日期:1993-10-01 00:00:00
abstract:STUDY DESIGN:A review of 60 surgical cases for correction of scoliosis, during which neuromotor evoked potentials and somatosensory evoked potentials were monitored. OBJECTIVES:To determine the validity and reliability of intraoperative neuromotor evoked potential monitoring in cases of scoliosis, where damage to the ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199910010-00012
更新日期:1999-10-01 00:00:00
abstract:STUDY DESIGN:A cross-sectional study to develop a cultural adaptation of the Marathi-neck disability index (NDI) and to investigate its validity and reliability. OBJECTIVE:To conduct a study concerning the cultural adaptation of the NDI and investigate the validity and reliability of its Marathi version in patients wi...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000681
更新日期:2015-01-15 00:00:00
abstract:STUDY DESIGN:Retrospective analysis of a population-based database. OBJECTIVE:To investigate national epidemiological trends of cervical spine surgical procedures from 2002-2009. SUMMARY OF BACKGROUND DATA:Anterior cervical fusion (ACF), posterior cervical fusion (PCF), and posterior cervical decompression (PCD) are ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31828be75d
更新日期:2013-06-15 00:00:00
abstract:STUDY DESIGN:Longitudinal case-controlled animal study. OBJECTIVE:To investigate the effect of an intervertebral disc (IVD) lesion on the proportion of slow, fast, and intermediate muscle fiber types in the multifidus muscle in sheep, and whether muscle fiber changes were paralleled by local gene expression of the pro...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000318
更新日期:2014-06-01 00:00:00
abstract:STUDY DESIGN:Case report. OBJECTIVE:Presentation of the previously unreported technique of balloon kyphoplasty being used to prophylactically stabilize a vertebral body metastasis at risk of imminent fracture. SUMMARY OF BACKGROUND DATA:Many patients with spinal metastases are not suitable for a total en bloc resecti...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181a482f6
更新日期:2009-06-01 00:00:00
abstract:STUDY DESIGN:A cross-sectional radiographic study. OBJECTIVE:The aim of this study was to establish the age- and sex-related normative values of whole-body sagittal alignment in asymptomatic Chinese adult population, and to investigate the changes and possible associated compensation mechanisms across age groups. SUM...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003187
更新日期:2020-01-15 00:00:00
abstract::The relationship betewwn compensation and three variables--psychologic disturbance, organic status, and pain report characteristics--was assessed. Patients on compensation were clinically similar to patients not on compensation in the relative frequency of cases of psychologic disturbance and nonorganic findings in ea...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198207000-00010
更新日期:1982-07-01 00:00:00
abstract:STUDY DESIGN:A prospective comparative imaging study. OBJECTIVE:This study investigated whether postoperative resolution of spinal cord increased signal intensity (ISI) reflected symptom improvement and surgical outcomes in cervical spondylotic myelopathy (CSM) patients. SUMMARY OF BACKGROUND DATA:Although some CSM p...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003128
更新日期:2019-11-01 00:00:00
abstract:STUDY DESIGN:Case report and review of the literature. OBJECTIVE:To report a patient presenting with Brown-Sequard syndrome due to cervical intradural disc herniation after spinal manipulation therapy. SUMMARY OF BACKGROUND DATA:Spinal manipulation therapy (SMT) is often used by people with neck pain or discomfort as...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181bee8a7
更新日期:2010-03-01 00:00:00
abstract::Idiopathic juvenile osteoporosis is an unusual condition appearing in the prepubertal child who is otherwise normal. Characteristically, the condition is of variable severity and of limited duration and always affect the spine. One of the major complications of idiopathic juvenile osteoporosis has been residual kyphos...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198101000-00001
更新日期:1981-01-01 00:00:00
abstract:STUDY DESIGN:A case series of idiopathic scoliosis patients treated with thoracoscopic anterior instrumentation was compared to a similar group of patients treated by open anterior instrumentation. OBJECTIVES:To evaluate the morbidity associated with thoracoscopic instrumentation compared to the open approach for thor...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.BRS.0000092475.04293.F5
更新日期:2003-10-15 00:00:00
abstract::STUDY DESIGN.: A prospective interventional case-series study plus a retrospective analysis of historical patients for comparison of data. OBJECTIVE.: To evaluate workflow, feasibility, and clinical outcome of navigated stabilization procedures with data acquisition by intraoperative computed tomography. SUMMARY OF BA...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181b77b19
更新日期:2009-12-15 00:00:00
abstract::A biomechanical model for studying lumbar muscle load sharing for a class of physical tasks that involve gravitational loading (holding weights) of the upper body in an erect posture is presented. The model assumes that the lumbar muscles balance the externally applied flexion and lateral bending moments. The concept ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198909000-00004
更新日期:1989-09-01 00:00:00