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Software tools for simultaneous data visualization and T cell epitopes and disorder prediction in proteins.

Abstract：

:We have developed EpDis and MassPred, extendable open source software tools that support bioinformatic research and enable parallel use of different methods for the prediction of T cell epitopes, disorder and disordered binding regions and hydropathy calculation. These tools offer a semi-automated installation of chosen sets of external predictors and an interface allowing for easy application of the prediction methods, which can be applied either to individual proteins or to datasets of a large number of proteins. In addition to access to prediction methods, the tools also provide visualization of the obtained results, calculation of consensus from results of different methods, as well as import of experimental data and their comparison with results obtained with different predictors. The tools also offer a graphical user interface and the possibility to store data and the results obtained using all of the integrated methods in the relational database or flat file for further analysis. The MassPred part enables a massive parallel application of all integrated predictors to the set of proteins. Both tools can be downloaded from http://bioinfo.matf.bg.ac.rs/home/downloads.wafl?cat=Software. Appendix A includes the technical description of the created tools and a list of supported predictors.

journal_name

J Biomed Inform

journal_title

Journal of biomedical informatics

authors

Jandrlić DR,Lazić GM,Mitić NS,Pavlović MD

doi

10.1016/j.jbi.2016.01.016

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

120-31

eissn

1532-0464

issn

1532-0480

pii

S1532-0464(16)00017-4

journal_volume

60

pub_type

杂志文章

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