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The MCM Helicase Motor of the Eukaryotic Replisome.

Abstract：

:The MCM motor of the CMG helicase powers ahead of the eukaryotic replication machinery to unwind DNA, in a process that requires ATP hydrolysis. The reconstitution of DNA replication in vitro has established the succession of events that lead to replication origin activation by the MCM and recent studies have started to elucidate the structural basis of duplex DNA unwinding. Despite the exciting progress, how the MCM translocates on DNA remains a matter of debate.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Abid Ali F,Costa A

doi

10.1016/j.jmb.2016.01.024

subject

Has Abstract

pub_date

2016-05-08 00:00:00

pages

1822-32

issue

9 Pt B

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(16)00043-7

journal_volume

428

pub_type

杂志文章,评审

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