Crofelemer for the symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS on anti-retroviral therapy.

abstract：:Ziprasidone, a benzisothiazolyl piperazine derivative of tiospirone, is a second-generation antipsychotic with high-affinity antagonism for 5-hydroxytryptophan (5HT)(2A), 5HT(2C), 5HT(1D) and D(2) receptors, pre- and post-synaptic agonism for 5HT(1A) receptors, and inhibition of reuptake for serotonin and norepinephri...

journal_title：Expert review of clinical pharmacology

authors： Sacchetti E,Galluzzo A,Valsecchi P

更新日期：2011-03-01 00:00:00

abstract：:Second-generation antipsychotics (SGA) have been associated with risk of stroke in elderly patients, but the molecular and genetic background under this association has been poorly investigated. The aim of the present study was to prioritize a list of genes with an SGA altered expression in order to characterize the g...

journal_title：Expert review of clinical pharmacology

authors： Cocchi E,Drago A,de Ronchi D,Serretti A

更新日期：2014-01-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are effective and widely used antihypertensive drugs. Exposure to these agents is known to be harmful to the fetus in the second and third trimesters of pregnancy. Concerns have also been raised about the risk of congenital malfo...

journal_title：Expert review of clinical pharmacology

authors： Pucci M,Sarween N,Knox E,Lipkin G,Martin U

更新日期：2015-03-01 00:00:00

abstract：:Introduction: Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease characterized by synovitis as well as symmetric and destructive arthropathy. Although several disease modified antirheumatic-drugs (DMARDs) have widely used in clinical practice, certain patients are nonresponsive to or cannot take suc...

journal_title：Expert review of clinical pharmacology

authors： Qiu Q,Feng Q,Tan X,Guo M

更新日期：2019-06-01 00:00:00

abstract：:Pharmacogenomics is a rapidly developing sector of human genetics research with arguably the highest potential for immediate benefit. There is a considerable body of evidence demonstrating that variability in drug-treatment response can be explained in part by genetic variation. Subsequently, much research has ensued ...

journal_title：Expert review of clinical pharmacology

authors： Turner SD,Crawford DC,Ritchie MD

更新日期：2009-09-01 00:00:00

abstract：:Alzheimer's disease is the most common cause of dementia and is becoming a global health concern. Despite a well-established understanding of the molecular mechanism involved in its pathogenesis, and millions of dollars of investment in drug discovery and clinical trials, no single molecule has yet been approved for i...

journal_title：Expert review of clinical pharmacology

authors： Léger GC,Massoud F

更新日期：2013-07-01 00:00:00

abstract：:Despite advances in our understanding of the molecular and genetic basis of pancreatic cancer, it continues to be a therapeutic challenge. Gemcitabine approved by FDA in 1997, offers modest improvement of tumor-related symptoms and marginal advantage of survival. Many chemotherapeutic agents have been compared against...

journal_title：Expert review of clinical pharmacology

authors： Saif MW

更新日期：2014-07-01 00:00:00

abstract：:Osteoarthritis is a progressive disease that affects millions of people worldwide, but for which there are no curative options and indeed a limited number of medical treatment options. The American College of Rheumatology recommendations suggest administering either a traditional NSAID or a COX-2-selective inhibitor f...

journal_title：Expert review of clinical pharmacology

authors： Sebba A

更新日期：2008-05-01 00:00:00

abstract：:Treatment of age-related macular degeneration (AMD) has changed dramatically over the last decade. It has evolved from primarily destructive therapies (laser-based treatment strategies) to nondestructive therapies (intravitreal pharmacotherapies that target angiogenesis). Intermittent intravitreal ranibizumab, an inhi...

journal_title：Expert review of clinical pharmacology

authors： McGimpsey SJ,Chakravarthy U

更新日期：2010-03-01 00:00:00

abstract：INTRODUCTION:Ocular dysfunctions and toxicities induced by antiepileptic drugs (AEDs) are rarely reviewed and not frequently received attention by treating physicians compared to other adverse effects (e.g. endocrinologic, cognitive and metabolic). However, some are frequent and progressive even in therapeutic concentr...

journal_title：Expert review of clinical pharmacology

authors： Hamed SA

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:Induction chemotherapy based on anthracyclines and cytarabine (Ara-C) combination remains the standard of care for acute myeloid leukemia (AML) patients who are considered candidate for intensive and curative approaches. However, the toxicity of this regimen is high, with disappointing clinical outcomes am...

journal_title：Expert review of clinical pharmacology

authors： Megías-Vericat JE,Martínez-Cuadrón D,Sanz MÁ,Poveda JL,Montesinos P

更新日期：2019-03-01 00:00:00

abstract：INTRODUCTION:Checkpoint inhibitor immunotherapy has revolutionized the treatment of many advanced stage cancers. Preexisting immunity is necessary for a response to these agents, which are most effective in inflamed tumors since they principally act by reinforcing preexisting antitumor T-cell responses. An important go...

journal_title：Expert review of clinical pharmacology

authors： Festino L,Vanella V,Trojaniello C,Ascierto PA

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:A new five-year low dose, smaller-framed, levonorgestrel-releasing intrauterine contraceptive system (LNG-IUS 12) has been introduced to complement the currently available systems. Areas Covered: This article will provide an overview of this new intrauterine system - its composition and its mechanisms of a...

journal_title：Expert review of clinical pharmacology

authors： Nelson AL

更新日期：2017-08-01 00:00:00

abstract：:Introduction: The clinical use of tacrolimus is characterized by many side effects which include neurotoxicity. In contrast, tacrolimus has also shown to have neuroregenerative properties. On a molecular level, the mechanisms of action could provide us more insight into understanding the neurobiological effects. The a...

journal_title：Expert review of clinical pharmacology

authors： Saffari TM,Bedar M,Zuidam JM,Shin AY,Baan CC,Hesselink DA,Hundepool CA

更新日期：2019-11-01 00:00:00

abstract：:Methotrexate is an antifolate agent used in the treatment of various cancers and some autoimmune diseases. In oncology, methotrexate is frequently administered at a high dose (>1 g/m(2)) and comes with various procedures to reduce the occurrence of toxicity and particularly to ensure optimal renal elimination. Drug-dr...

journal_title：Expert review of clinical pharmacology

authors： Levêque D,Santucci R,Gourieux B,Herbrecht R

更新日期：2011-11-01 00:00:00

abstract：:Introduction: Combined antiretroviral therapy (cART) has transformed an inexorably fatal disease into a chronic pathology, shifting the focus of research from the control of viral replication to the possibility of HIV cure. Areas covered: The present review assesses the principal pharmacological strategies that have b...

journal_title：Expert review of clinical pharmacology

authors： Giacomelli A,de Rose S,Rusconi S

更新日期：2019-01-01 00:00:00

abstract：:Introduction: An important gap within modern medicine is the lack of enough comparative effectiveness research of marketed medicines. Low-risk pragmatic randomized controlled trials (pRCTs) are those conducted resembling usual clinical practice that poses no or minimal incremental risk compared with normal clinical pr...

journal_title：Expert review of clinical pharmacology

authors： Dal-Ré R

更新日期：2020-03-01 00:00:00

abstract：:Reducing the burden of falciparum malaria in pregnancy is an urgent international public health priority but one that involves considerable challenges. The rapidly declining effectiveness of agents known to be safe in pregnancy, and the limited efficacy, safety and pharmacokinetic data available for many other antimal...

journal_title：Expert review of clinical pharmacology

authors： Vallely A,McCarthy J,Changalucha J,Vallely L,Chandramohan D

更新日期：2008-01-01 00:00:00

abstract：:The last decades were characterized by enormous technological advances resulting in a better understanding of disease pathologies and improvement of treatment strategies. The development of targeted drugs, whose beginning can be traced back to Paul Ehrlich's theory of the 'magic bullet' approximately 100 years ago, is...

journal_title：Expert review of clinical pharmacology

authors： Hebar A,Valent P,Selzer E

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:In pediatric pharmacotherapy, many drugs are still used off-label, and their efficacy and safety is not well characterized. Different efficacy and safety profiles in children of varying ages may be anticipated, due to developmental changes occurring across pediatric life. AREAS COVERED:Beside pharmacokine...

journal_title：Expert review of clinical pharmacology

authors： Brussee JM,Calvier EA,Krekels EH,Välitalo PA,Tibboel D,Allegaert K,Knibbe CA

更新日期：2016-09-01 00:00:00

abstract：:Sugammadex, a modified γ-cyclodextrin, is the first selective relaxant binding agent. Sugammadex forms very tight complexes in a 1:1 ratio with steroidal neuromuscular blocking agents (rocuronium > vecuronium > pancuronium). This guest-host complex, which exists in equilibrium, is stable because of its very high assoc...

journal_title：Expert review of clinical pharmacology

authors： Naguib M,Brull SJ

更新日期：2009-01-01 00:00:00

abstract：:RNAi is a powerful gene silencing process that holds great promise in cancer therapy by the use of siRNA. The aim of this review is to give an outline on different approaches to deliver siRNA and to describe the advantages and disadvantages of these systems. The prospects for siRNA are to be substantially better than ...

journal_title：Expert review of clinical pharmacology

authors： Ali HM,Urbinati G,Raouane M,Massaad-Massade L

更新日期：2012-07-01 00:00:00

abstract：:Neuroblastoma (NB) is the most common extra cranial solid tumor of childhood, with 60% of patients presenting with high risk (HR) NB by means of clinical, pathological and biological features. The 5-year survival rate for HR-NB remains below 40%, with the majority of patients suffering relapse from chemorefractory tum...

journal_title：Expert review of clinical pharmacology

authors： Mora J

更新日期：2016-01-01 00:00:00

abstract：:The anti-tumor activity of CpG-containing oligodeoxynucleotides (ODNs) has been well established in numerous animal models and confirmed in a number of early clinical trials. While the use of chemical modifications has effectively reduced the sensitivity of ODNs to nuclease degradation and a number of human trials hav...

journal_title：Expert review of clinical pharmacology

authors： Wilson KD,Tam YK

更新日期：2009-03-01 00:00:00

abstract：:C-X-C chemokine receptor (CXCR)3 and its interferon(IFN)γ-dependent chemokines (CXCL10, CXCL9, CXCL11) are implicated in the immune-pathogenesis of autoimmune thyroiditis (AT), Graves disease (GD) and Graves Ophthalmopathy (GO). In tissue, recruited Th1 lymphocytes produce IFNγ, enhancing the tissue secretion of IFNγ-...

journal_title：Expert review of clinical pharmacology

authors： Fallahi P,Ferrari SM,Elia G,Nasini F,Colaci M,Giuggioli D,Vita R,Benvenga S,Ferri C,Antonelli A

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:Osteoarthritis constitutes one of the leading causes of pain and disability worldwide with a significant impact on health-care costs. Patients with osteoarthritis are often affected by a number of cardiovascular comorbidities, including hypertension, which is present in about 40% of cases. Just recently, a...

journal_title：Expert review of clinical pharmacology

authors： Angeli F,Trapasso M,Signorotti S,Verdecchia P,Reboldi G

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Diabetes mellitus is associated with increased cardiovascular disease (CVD) risk. Areas covered: Main goal of hypolipidemic treatment in diabetic patients is low-density lipoprotein cholesterol (LDL-C) lowering with the use of statins. Addition of ezetimibe is useful in diabetic patients who cannot achieve...

journal_title：Expert review of clinical pharmacology

authors： Filippatos TD,Florentin M,Georgoula M,Elisaf MS

更新日期：2017-02-01 00:00:00

abstract：:The unprecedented levels of political, technical and financial support for improved malaria control, and particularly for changes in the malaria treatment policy, have heralded a renewed appreciation of the role of pharmacovigilance, its relationship with other areas of public health and the development of novel appro...

journal_title：Expert review of clinical pharmacology

authors： Mehta U,Allen E,Barnes KI

更新日期：2010-07-01 00:00:00

abstract：:Chagas disease is the highest impact parasitic disease in the Americas but often goes untreated due to the shortcomings of currently available therapeutics. Thus there is an urgent need for new treatment options and growing interest in drug development for the infection. This review summarizes some of the recent advan...

journal_title：Expert review of clinical pharmacology

authors： Bustamante JM,Tarleton RL

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Allogeneic hematopoietic cell transplants (allo-HCT) recipients are at the high-risk of reactivation of cytomegalovirus (CMV), and reactivation is associated with significant morbidity and mortality. Although available anti-CMV therapies may be effective for the prevention of CMV, they are plagued by unacc...

journal_title：Expert review of clinical pharmacology

authors： Foolad F,Aitken SL,Chemaly RF

更新日期：2018-10-01 00:00:00