VEGF-targeted therapy and beyond: pharmacotherapy and emerging treatments in agerelated macular degeneration.

abstract：:Osteoarthritis is a progressive disease that affects millions of people worldwide, but for which there are no curative options and indeed a limited number of medical treatment options. The American College of Rheumatology recommendations suggest administering either a traditional NSAID or a COX-2-selective inhibitor f...

journal_title：Expert review of clinical pharmacology

authors： Sebba A

更新日期：2008-05-01 00:00:00

abstract：:Methotrexate is an antifolate agent used in the treatment of various cancers and some autoimmune diseases. In oncology, methotrexate is frequently administered at a high dose (>1 g/m(2)) and comes with various procedures to reduce the occurrence of toxicity and particularly to ensure optimal renal elimination. Drug-dr...

journal_title：Expert review of clinical pharmacology

authors： Levêque D,Santucci R,Gourieux B,Herbrecht R

更新日期：2011-11-01 00:00:00

abstract：:The aim of this article was to assess the efficacy and safety of apremilast in treatment of psoriatic arthritis (PsA) with meta-analysis method. We included four randomized clinical trials identified from MEDLINE, EMBASE, Cochrane Library, "ISRCTN Register" and "ClinicalTrials.gov" which compared apremilast with place...

journal_title：Expert review of clinical pharmacology

authors： Qu X,Zhang S,Tao L,Song Y

更新日期：2016-06-01 00:00:00

abstract：:Introduction: Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease characterized by synovitis as well as symmetric and destructive arthropathy. Although several disease modified antirheumatic-drugs (DMARDs) have widely used in clinical practice, certain patients are nonresponsive to or cannot take suc...

journal_title：Expert review of clinical pharmacology

authors： Qiu Q,Feng Q,Tan X,Guo M

更新日期：2019-06-01 00:00:00

abstract：:Introduction: Dementia is the 7th leading cause of death that imposes a significant financial and service burden on the global population. Presently, only symptomatic care exists for cognitive loss, such as Alzheimer's disease.Areas covered: Given the advancing age of the global population, it becomes imperative to de...

journal_title：Expert review of clinical pharmacology

authors： Maiese K

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Joint hypermobility (JH) is the hallmark of many hereditary soft connective tissue disorders, including Ehlers-Danlos syndromes and related disorders, disorders of the TGFβ-pathway, lateral meningocele syndrome, arterial tortuosity syndrome, and cutis laxa syndromes. Contemporary practice separates individ...

journal_title：Expert review of clinical pharmacology

authors： Baban A,Castori M

更新日期：2018-07-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is now considered a member of a group of signaling molecules termed 'gasotransmitters'. H(2)S has been shown to be generated in the endocrine and reproductive organs and elicits various actions. H(2)S modulates insulin secretion in pancreatic islets. Adipose tissues have the ability to produce...

journal_title：Expert review of clinical pharmacology

authors： Zhu XY,Gu H,Ni X

更新日期：2011-01-01 00:00:00

abstract：:C-X-C chemokine receptor (CXCR)3 and its interferon(IFN)γ-dependent chemokines (CXCL10, CXCL9, CXCL11) are implicated in the immune-pathogenesis of autoimmune thyroiditis (AT), Graves disease (GD) and Graves Ophthalmopathy (GO). In tissue, recruited Th1 lymphocytes produce IFNγ, enhancing the tissue secretion of IFNγ-...

journal_title：Expert review of clinical pharmacology

authors： Fallahi P,Ferrari SM,Elia G,Nasini F,Colaci M,Giuggioli D,Vita R,Benvenga S,Ferri C,Antonelli A

更新日期：2016-06-01 00:00:00

abstract：:The problem of adverse drug reactions is a well-documented global public health problem. Recent withdrawals of several widely used prescription medications in the USA and other countries have raised concerns among patients, clinicians, scientists and policy makers. The increasing interest and concern regarding withdra...

journal_title：Expert review of clinical pharmacology

authors： Issa AM

更新日期：2008-03-01 00:00:00

abstract：INTRODUCTION:Ocular dysfunctions and toxicities induced by antiepileptic drugs (AEDs) are rarely reviewed and not frequently received attention by treating physicians compared to other adverse effects (e.g. endocrinologic, cognitive and metabolic). However, some are frequent and progressive even in therapeutic concentr...

journal_title：Expert review of clinical pharmacology

authors： Hamed SA

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:Anti-vascular endothelial growth factor (VEGF) therapy has become the most commonly used treatment for macular edema secondary to retinal vein occlusion (RVO). Although its superior efficacy as compared to other interventions has been proven, there is a lack of evidence for relative efficacy among anti-VEG...

journal_title：Expert review of clinical pharmacology

authors： Sangroongruangsri S,Ratanapakorn T,Wu O,Anothaisintawee T,Chaikledkaew U

更新日期：2018-09-01 00:00:00

abstract：:The last decades were characterized by enormous technological advances resulting in a better understanding of disease pathologies and improvement of treatment strategies. The development of targeted drugs, whose beginning can be traced back to Paul Ehrlich's theory of the 'magic bullet' approximately 100 years ago, is...

journal_title：Expert review of clinical pharmacology

authors： Hebar A,Valent P,Selzer E

更新日期：2013-01-01 00:00:00

abstract：:Rosacea is a chronic inflammatory dermatologic condition that can often be disfiguring with significant negative impact on patients' quality of life. Sanrosa (brimonidine tartate) is a novel therapeutic agent targeting the facial flushing and erythema of rosacea through its α₂ adrenergic receptor agonist activity. The...

journal_title：Expert review of clinical pharmacology

authors： Tong LX,Moore AY

更新日期：2014-09-01 00:00:00

abstract：:Background: The RESORT trial showed no longer relapse free survival (RFS) with sorafenib following radical metastasectomy in metastatic renal cell carcinoma. We present the updated 42-month follow-up data. Methods: The phase II RESORT trial randomized patients to sorafenib or observation within 12 weeks from surgery. ...

journal_title：Expert review of clinical pharmacology

authors： Mennitto A,Verzoni E,Cognetti F,Miceli R,Milella M,Mosca A,Chiuri VE,Bearz A,Morelli F,Ortega C,Atzori F,Donini M,Claps M,Guadalupi V,Sepe P,Cappelletti V,de Braud FG,Procopio G

更新日期：2021-01-31 00:00:00

abstract：:The anti-tumor activity of CpG-containing oligodeoxynucleotides (ODNs) has been well established in numerous animal models and confirmed in a number of early clinical trials. While the use of chemical modifications has effectively reduced the sensitivity of ODNs to nuclease degradation and a number of human trials hav...

journal_title：Expert review of clinical pharmacology

authors： Wilson KD,Tam YK

更新日期：2009-03-01 00:00:00

abstract：:Introduction: An important gap within modern medicine is the lack of enough comparative effectiveness research of marketed medicines. Low-risk pragmatic randomized controlled trials (pRCTs) are those conducted resembling usual clinical practice that poses no or minimal incremental risk compared with normal clinical pr...

journal_title：Expert review of clinical pharmacology

authors： Dal-Ré R

更新日期：2020-03-01 00:00:00

abstract：:Preeclampsia is a pregnancy-specific multisystem disorder, complicating 2 - 8% of pregnancies, and represents a leading cause of maternal and perinatal morbidity and mortality. Recent investigations have elucidated the understanding of its underlying pathogenic mechanisms. However, despite these advances, therapeutic ...

journal_title：Expert review of clinical pharmacology

authors： Ornaghi S,Paidas MJ

更新日期：2014-09-01 00:00:00

abstract：INTRODUCTION:The need to develop new drugs for the control of pathogenic microorganisms has redoubled efforts to prospect for antimicrobial peptides (AMPs) from natural sources and to characterize its structure and function. These molecules present a broad spectrum of action against different microorganisms and frequen...

journal_title：Expert review of clinical pharmacology

authors： Sampaio de Oliveira KB,Leite ML,Rodrigues GR,Duque HM,da Costa RA,Cunha VA,de Loiola Costa LS,da Cunha NB,Franco OL,Dias SC

更新日期：2020-04-01 00:00:00

abstract：:Second-generation antipsychotics (SGA) have been associated with risk of stroke in elderly patients, but the molecular and genetic background under this association has been poorly investigated. The aim of the present study was to prioritize a list of genes with an SGA altered expression in order to characterize the g...

journal_title：Expert review of clinical pharmacology

authors： Cocchi E,Drago A,de Ronchi D,Serretti A

更新日期：2014-01-01 00:00:00

abstract：:The thermo transient receptor potential (TRP) ion channels, a recently discovered family of ion channels activated by temperature, are expressed in primary sensory nerve terminals, where they provide information regarding thermal changes in the environment. Six thermo-TRPs have been characterized to date: TRPV1-4, whi...

journal_title：Expert review of clinical pharmacology

authors： Vay L,Gu C,McNaughton PA

更新日期：2010-09-01 00:00:00

abstract：:Chronic diarrhea remains a common condition that affects people infected with human immunodeficiency virus (HIV) despite the widespread use of potent antiretroviral therapy. It is important that providers control this condition, as the persistence of diarrhea affects the quality of life of patients and may contribute ...

journal_title：Expert review of clinical pharmacology

authors： Castro JG,Chin-Beckford N

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:To estimate the prevalence of polypharmacy (≥5 drugs) among adults and to analyze related factors. METHODS:Cross-sectional study with 1,159 interviewees distributed across 104 cities and 253 primary healthcare services delivered through the Brazilian Unified Health System. Polypharmacy-related factors were ...

journal_title：Expert review of clinical pharmacology

authors： Moreira T,Alvares-Teodoro J,Barbosa MM,Do Nascimento RCRM,Guerra Júnior AA,Acurcio FA

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Checkpoint inhibitor immunotherapy has revolutionized the treatment of many advanced stage cancers. Preexisting immunity is necessary for a response to these agents, which are most effective in inflamed tumors since they principally act by reinforcing preexisting antitumor T-cell responses. An important go...

journal_title：Expert review of clinical pharmacology

authors： Festino L,Vanella V,Trojaniello C,Ascierto PA

更新日期：2018-10-01 00:00:00

abstract：:The oxazolidinones are a new class of antibiotics whose mechanism of action is the inhibition of bacterial protein synthesis by binding to the 50S ribosomal subunit. Linezolid is the first member of this class of antibiotics to be approved by the US FDA and other regulatory bodies for the treatment of infections cause...

journal_title：Expert review of clinical pharmacology

authors： Tan TQ,Yogev R

更新日期：2008-07-01 00:00:00

abstract：INTRODUCTION:Drug-resistant forms of tuberculosis are a major public health problem with a serious global impact. Although there have recently been two new drugs introduced for the treatment of drug-resistant TB (bedaquiline and delamanid), the current therapeutic armamentarium is limited. Because treatment of drug-res...

journal_title：Expert review of clinical pharmacology

authors： Mafukidze A,Harausz E,Furin J

更新日期：2016-10-01 00:00:00

abstract：:Migraine is a common neurological syndrome that affects approximately 10-20% of the population. The pathophysiology of migraine is unclear. 5-hydroxytriptamine is a key mediator in the pathogenesis of migraine and thus 5-HT1-receptor agonists are the principal drugs for acute migraine therapy. There are three classes ...

journal_title：Expert review of clinical pharmacology

authors： Reddy DS

更新日期：2013-05-01 00:00:00

abstract：:Ziprasidone, a benzisothiazolyl piperazine derivative of tiospirone, is a second-generation antipsychotic with high-affinity antagonism for 5-hydroxytryptophan (5HT)(2A), 5HT(2C), 5HT(1D) and D(2) receptors, pre- and post-synaptic agonism for 5HT(1A) receptors, and inhibition of reuptake for serotonin and norepinephri...

journal_title：Expert review of clinical pharmacology

authors： Sacchetti E,Galluzzo A,Valsecchi P

更新日期：2011-03-01 00:00:00

abstract：:Over the last two decades, research developments have revolutionized our understanding of the pathogenesis of psoriasis and of the contribution of several cytokines in the manifestation of the disease. The key role of TNF-α in the pathogenesis of psoriasis has been extensively studied and its therapeutic action, initi...

journal_title：Expert review of clinical pharmacology

authors： Vergou T,Moustou AE,Sfikakis PP,Antoniou C,Stratigos AJ

更新日期：2011-07-01 00:00:00

abstract：:Inflammation plays a critical role in host defense, maintaining cellular and tissue integrity following chemical, physical and biological insults. Inflammation presents in a variety of acute and chronic disease states and can contribute to disease resolution or progression depending upon the type, magnitude and durati...

journal_title：Expert review of clinical pharmacology

authors： Cressman AM,Petrovic V,Piquette-Miller M

更新日期：2012-01-01 00:00:00

abstract：:Valproic acid is approved for treatment of seizures and manic episodes of bipolar disorder, and continues to be one of the most commonly prescribed antiepileptic drugs in the world. Hepatotoxicity is a rare but serious side effect resulting from its use, particularly in young patients. This adverse effect does not dis...

journal_title：Expert review of clinical pharmacology

authors： Felker D,Lynn A,Wang S,Johnson DE

更新日期：2014-03-01 00:00:00