Tolerance of Volume Control Noninvasive Ventilation in Subjects With Amyotrophic Lateral Sclerosis.

Abstract:

BACKGROUND:Noninvasive ventilation (NIV) tolerance has been identified as an independent predictor of survival in amyotrophic lateral sclerosis (ALS). Volume control continuous mandatory ventilation (VC-CMV) NIV has been associated with poor tolerance. The aim of this study was to determine the tolerance of subjects with ALS to VC-CMV NIV. METHODS:This was a prospective study involving subjects with ALS who were treated with VC-CMV NIV. Respiratory and functional parameters were recorded when the subjects began ventilatory support. NIV tolerance was evaluated after 3 months. RESULTS:Eighty-seven subjects with ALS were included. After 3 months, 80 subjects (92%) remained tolerant of NIV. Tolerant subjects presented greater survival (median 22.0 months, 95% CI 14.78-29.21) than intolerant subjects (median 6.0 months, 95% CI 0.86-11.13) (P = .03). The variables that best predicted NIV tolerance were mechanically assisted cough peak flow (P = .01) and percentage of time spent with SpO2 < 90% at night while on NIV (P = .03) CONCLUSIONS: VC-CMV NIV provides high rates of NIV tolerance in subjects with ALS. Mechanically assisted cough peak flow and percentage of time spent with SpO2 < 90% at night while using NIV are the 2 factors associated with tolerance of VC-CMV NIV in subjects with ALS.

journal_name

Respir Care

journal_title

Respiratory care

authors

Martínez D,Sancho J,Servera E,Marín J

doi

10.4187/respcare.04172

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

1765-71

issue

12

eissn

0020-1324

issn

1943-3654

pii

respcare.04172

journal_volume

60

pub_type

杂志文章
  • The evaluation and management of accidental hypothermia.

    abstract::Accidental hypothermia is defined as an unintentional decrease in core body temperature to below 35 degrees C. Hypothermia causes hundreds of deaths in the United States annually. Victims of accidental hypothermia present year-round and in all climates with a potentially confusing array of signs and symptoms, but incr...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:

    authors: Kempainen RR,Brunette DD

    更新日期:2004-02-01 00:00:00

  • Reduced Diaphragm Excursion During Reflexive Citric Acid Cough Test in Subjects With Subacute Stroke.

    abstract:BACKGROUND:Diaphragm excursion is limited during respiratory maneuvers after a stroke. How the diaphragm is limited during reflexive coughs and affects the effectiveness of cough in stroke patients is unclear. This study aimed to measure reflexive cough strength by cough peak flow (CPF) induced by citric acid nebulizat...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.05488

    authors: Choi YM,Park GY,Yoo Y,Sohn D,Jang Y,Im S

    更新日期:2017-12-01 00:00:00

  • Growth of nasal and laryngeal airways in children: implications in breathing and inhaled aerosol dynamics.

    abstract:BACKGROUND:The human respiratory airway undergoes dramatic growth during infancy and childhood, which induces substantial variability in air flow pattern and particle deposition. However, deposition studies have typically focused on adult subjects, the results of which cannot be readily extrapolated to children. We dev...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.02568

    authors: Xi J,Si X,Zhou Y,Kim J,Berlinski A

    更新日期:2014-02-01 00:00:00

  • The 2017 Global Initiative for Chronic Obstructive Lung Disease Report and Practice Implications for the Respiratory Therapist.

    abstract::Since 1998, the Global Initiative for Obstructive Lung Disease (GOLD) has worked with health care professionals, medical researchers, and public health officials around the world to optimize the prevention, treatment, and management of COPD. GOLD has continually worked to ensure COPD management strategy recommendation...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.05402

    authors: Hess MW

    更新日期:2017-11-01 00:00:00

  • Issues in drug delivery: concepts and practice.

    abstract::Understanding the transport and deposition of inhaled aerosols is of fundamental importance to inhalation therapy. Herein we address issues that affect drug delivery from experimental and theoretical perspectives. Accordingly, we shall limit our comments to a focused review of laboratory work (ie, an in vitro perspect...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:

    authors: Martonen TB,Smyth HD,Isaacs KK,Burton RT

    更新日期:2005-09-01 00:00:00

  • Value of Plethysmographic Pulse Amplitude Ratio With Valsalva Maneuver in Identifying Left Ventricular Dysfunction During COPD Exacerbation.

    abstract:BACKGROUND:Left-ventricular dysfunction associated with COPD exacerbation is frequently underestimated. We tested whether finger plethysmography waveform change during the Valsalva maneuver could aid in the distinction between patients with COPD exacerbation with and without left-ventricular dysfunction. METHODS:We in...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.04091

    authors: Boubaker H,Grissa MH,Debbabi H,Beltaief K,Dridi Z,Najjar MF,Bouida W,Boukef R,Marghli S,Nouira S

    更新日期:2016-04-01 00:00:00

  • Performance of Leak Compensation in All-Age ICU Ventilators During Volume-Targeted Neonatal Ventilation: A Lung Model Study.

    abstract:BACKGROUND:Volume-targeted ventilation is increasingly used in low birthweight infants because of the potential for reducing volutrauma and avoiding hypocapnea. However, it is not known what level of air leak is acceptable during neonatal volume-targeted ventilation when leak compensation is activated concurrently. ME...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.05012

    authors: Itagaki T,Bennett DJ,Chenelle CT,Fisher DF,Kacmarek RM

    更新日期:2017-01-01 00:00:00

  • Use of a single ventilator to support 4 patients: laboratory evaluation of a limited concept.

    abstract:INTRODUCTION:A mass-casualty respiratory failure event where patients exceed available ventilators has spurred several proposed solutions. One proposal is use of a single ventilator to support 4 patients. METHODS:A ventilator was modified to allow attachment of 4 circuits. Each circuit was connected to one chamber of...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.01236

    authors: Branson RD,Blakeman TC,Robinson BR,Johannigman JA

    更新日期:2012-03-01 00:00:00

  • Impact of Home Oxygen Therapy on the Level of Physical Activities in Daily Life in Subjects With COPD.

    abstract:BACKGROUND:Chronic hypoxemia in patients with COPD is a limiting factor that is associated with disease progression and significantly contributes to decreased physical activity. Although correction of hypoxemia results in physiological improvements, oxygen therapy may be related to social isolation and inactivity. Howe...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.06206

    authors: Cani KC,Matte DL,Silva IJCS,Gulart AA,Karloh M,Mayer AF

    更新日期:2019-11-01 00:00:00

  • Comparison of usual and alternative methods to measure height in mechanically ventilated patients: potential impact on protective ventilation.

    abstract:BACKGROUND:Protective ventilation implementation requires the calculation of predicted body weight (PBW), determined by a formula based on gender and height. Consequently, height inaccuracy may be a limiting factor to correctly set tidal volumes. The objective of this study was to evaluate the accuracy of different met...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.02732

    authors: Bojmehrani A,Bergeron-Duchesne M,Bouchard C,Simard S,Bouchard PA,Vanderschuren A,L'Her E,Lellouche F

    更新日期:2014-07-01 00:00:00

  • Positive expiratory pressure changes aerosol distribution in patients with cystic fibrosis.

    abstract:HYPOTHESIS:We hypothesized that aerosol distribution in the lungs of patients with cystic fibrosis changes with positive expiratory pressure (PEP). METHODS:Eight patients were randomized to one of 2 conditions. On one study day, patients inhaled saline aerosol containing 99mtechnetium generated by a Pari LC Plus nebul...

    journal_title:Respiratory care

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Laube BL,Geller DE,Lin TC,Dalby RN,Diener-West M,Zeitlin PL

    更新日期:2005-11-01 00:00:00

  • Weaning from mechanical ventilation: the evidence from clinical research.

    abstract::Mechanical ventilation incurs substantial morbidity, mortality, and costs. Both premature extubation and delayed extubation can cause harm. Therefore, weaning that is both expeditious and safe is highly desirable. The purpose of this review is to summarize the literature related to weaning modes, spontaneous breathing...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:

    authors: Meade MO,Guyatt GH,Cook DJ

    更新日期:2001-12-01 00:00:00

  • Patient-Reported Outcome Measures for Symptom Perception During a Cystic Fibrosis Exacerbation.

    abstract:BACKGROUND:Symptom burden increases during pulmonary exacerbations of cystic fibrosis (CF), and patient-reported outcome measures (PROMs) are often used to evaluate symptoms as either primary or secondary outcomes. However, there is currently no guidance on the use of PROMs to assess symptom burden during pulmonary exa...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:10.4187/respcare.05638

    authors: Schmid-Mohler G,Caress AL,Spirig R,Benden C,Yorke J

    更新日期:2018-03-01 00:00:00

  • Historical highlights of long-term oxygen therapy.

    abstract::The story of the development of oxygen and its role in mitigating the ravages of chronic stable hypoxemia have been fascinating. Today, over one million Americans receive home oxygen each day, usually for COPD, from one of the three available systems. The future requires less expensive, highly portable, and practical ...

    journal_title:Respiratory care

    pub_type: 历史文章,杂志文章

    doi:

    authors: Petty TL

    更新日期:2000-01-01 00:00:00

  • Respiratory dysfunction and pulmonary disease in cirrhosis and other hepatic disorders.

    abstract::End-stage liver disease and its complications are a leading cause of death among adults in the United States, and thousands of patients await liver transplantation. The liver plays a central role in health and homeostasis and thus the diseased liver leads to many deleterious effects on multiple organ systems, includin...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:

    authors: Huffmyer JL,Nemergut EC

    更新日期:2007-08-01 00:00:00

  • Randomized controlled trial of a breath-actuated nebulizer in pediatric asthma patients in the emergency department.

    abstract:BACKGROUND:Bronchodilator treatment for asthma can be provided with various aerosol-generating devices and methods. There have been no randomized trials of a breath-actuated nebulizer versus continuous 1-hour nebulization and/or small-volume constant-output nebulizer in pediatric asthma patients. METHODS:We conducted ...

    journal_title:Respiratory care

    pub_type: 杂志文章,随机对照试验

    doi:10.4187/respcare.00142

    authors: Sabato K,Ward P,Hawk W,Gildengorin V,Asselin JM

    更新日期:2011-06-01 00:00:00

  • Congenital pulmonary airway malformation: a case report and review of the literature.

    abstract::Congenital parenchymal lung malformations have an estimated incidence at 1:25,000-1:35,000 births. We present a case of this rare congenital abnormality in a 38 year-old male, review the current literature with discussion of proposed causes, malignant potential, and management strategies. A 38-year-old white male pre...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:10.4187/respcare.00727

    authors: McDonough RJ,Niven AS,Havenstrite KA

    更新日期:2012-02-01 00:00:00

  • Relationship between functional residual capacity, respiratory compliance, and oxygenation in patients ventilated after cardiac surgery.

    abstract:BACKGROUND:Measurement of functional residual capacity (FRC) is now possible at bedside, during mechanical ventilation. OBJECTIVES:To determine the relationship of measured absolute and relative predicted FRC values to oxygenation and respiratory-system compliance, and to identify variables that influence FRC in venti...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:

    authors: Heinze H,Sedemund-Adib B,Heringlake M,Meier T,Eichler W

    更新日期:2010-05-01 00:00:00

  • Home-Based Pulmonary Rehabilitation for Subjects With COPD: A Randomized Study.

    abstract:BACKGROUND:The aim of this study was to develop an efficient, low-cost, home-based pulmonary rehabilitation program and to evaluate the impact of the program on exercise as measured by the 6-min walk test (6MWT) and treadmill endurance test. METHODS:Twenty-nine subjects with COPD (FEV1 = 62.4 ± 10.7% of predicted, 62....

    journal_title:Respiratory care

    pub_type: 杂志文章,随机对照试验

    doi:10.4187/respcare.02994

    authors: Pradella CO,Belmonte GM,Maia MN,Delgado CS,Luise AP,Nascimento OA,Gazzotti MR,Jardim JR

    更新日期:2015-04-01 00:00:00

  • Removal of the CPAP Therapy Device During Sleep and Its Association With Body Position Changes and Oxygen Desaturations.

    abstract:BACKGROUND:Some patients with obstructive sleep apnea syndrome remove the CPAP device during sleep, although they start CPAP at bedtime. We hypothesized that body position changes and oxygen desaturations may be associated with patient removal of the CPAP device. METHODS:We consecutively enrolled 36 poor CPAP adherers...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.03520

    authors: Yamaguchi Y,Hibi S,Ishii M,Hanaoka Y,Yamamoto H,Ouchi Y,Akishita M

    更新日期:2015-05-01 00:00:00

  • Is a nasopharyngeal tube effective as interface to provide bi-level noninvasive ventilation?

    abstract:BACKGROUND:The nasopharyngeal tube (NT) is a potential interface for noninvasive ventilation (NIV) available in all health care centers. The aim of the study was to describe our experience in the use of the NT for bi-level NIV in infants and its effectiveness. METHODS:Prospective observational study from January 2007 ...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.02556

    authors: Velasco Arnaiz E,Cambra Lasaosa FJ,Hernández Platero L,Millán García Del Real N,Pons-Òdena M

    更新日期:2014-04-01 00:00:00

  • Pulmonary rehabilitation for chronic obstructive pulmonary disease: a scientific and political agenda.

    abstract::Pulmonary rehabilitation (PR) is the standard of care for patients suffering chronic obstructive pulmonary disease (COPD). This report describes and defines PR and reviews the evidence regarding the efficacy of PR. COPD management guidelines that include PR have been published by the European Respiratory Society, the ...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:

    authors: Fahy BF

    更新日期:2004-01-01 00:00:00

  • Reduction of Endotracheal Tube Connector Dead Space Improves Ventilation: A Bench Test on a Model Lung Simulating an Extremely Low Birth Weight Neonate.

    abstract:BACKGROUND:The reduction of instrumental dead space is a recognized approach to preventing ventilation-induced lung injury in premature infants. However, there are no published data regarding the effectiveness of instrumental dead-space reduction in endotracheal tube (ETT) connectors. We tested the impact of the Y-piec...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.04076

    authors: Ivanov VA

    更新日期:2016-02-01 00:00:00

  • Usefulness of Oscillations Added to Mechanical In-Exsufflation in Amyotrophic Lateral Sclerosis.

    abstract:BACKGROUND:Assisted coughing via mechanical in-exsufflation (MI-E) is a first-line treatment for secretion management in patients with amyotrophic lateral sclerosis (ALS) with unassisted CPF < 4.25 L/s. Some devices enable oscillations to be added to MI-E (MI-E+O). We sought to determine whether adding oscillations to ...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.07202

    authors: Sancho J,Burés E,Ferrer S,Bondía E,Servera E

    更新日期:2020-05-01 00:00:00

  • Respiratory Implications of Pediatric Neuromuscular Disease.

    abstract::Children with progressive neuromuscular weakness undergo a stereotypical progression of respiratory involvement, beginning with impaired airway clearance and progressing to nocturnal and then diurnal ventilatory failure. This review examines issues related to airway clearance and mucus mobilization, sleep problems, an...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:10.4187/respcare.05250

    authors: Panitch HB

    更新日期:2017-06-01 00:00:00

  • Humidification Performance of Passive and Active Humidification Devices Within a Spontaneously Breathing Tracheostomized Cohort.

    abstract:BACKGROUND:Most heat-and-moisture exchangers (HMEs) for patients with tracheostomy and spontaneously breathing are small and have suction ports that allow some expiratory gas to escape, which loses water vapor held in the expired gas. Recently, a heated-and-humidified high-flow system for spontaneously breathing patien...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.06294

    authors: Nakanishi N,Oto J,Itagaki T,Nakataki E,Onodera M,Nishimura M

    更新日期:2019-02-01 00:00:00

  • Patient-ventilator interactions: optimizing conventional ventilation modes.

    abstract::Assisted (interactive) breathing is generally preferred to controlled breaths in patients on mechanical ventilators. Assisted breaths allow the patient's respiratory muscles to be used, and ventilatory muscle atrophy can be prevented. Moreover, the respiratory drive of the patient does not have to be aggressively blun...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.00953

    authors: MacIntyre NR

    更新日期:2011-01-01 00:00:00

  • High-Flow Nasal Cannula in a Mixed Adult ICU.

    abstract:BACKGROUND:Humidified, high-flow nasal cannula (HFNC) enables mucociliary clearance, accurate oxygen measurement, precise control of flow, and low-level positive airway pressure. There is sparse information concerning the timing of HFNC on patient outcomes such as incidence of adverse events during hospitalization, ICU...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.04016

    authors: Gaunt KA,Spilman SK,Halub ME,Jackson JA,Lamb KD,Sahr SM

    更新日期:2015-10-01 00:00:00

  • Unilateral expiratory airflow obstruction during forced exhalation.

    abstract::We present a case of unilateral airflow obstruction during forced exhalations. The patient presented with episodic dyspnea and wheezing, particularly when he lay in the right lateral decubitus position. Spirometry revealed symmetric, marked reductions in forced expiratory volume in the first second and forced vital ca...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:

    authors: Hatipoglu U,Laghi F,Cattapan SE,Chandrasekhar AJ

    更新日期:2002-06-01 00:00:00

  • Computerized adventitious respiratory sounds as outcome measures for respiratory therapy: a systematic review.

    abstract:INTRODUCTION:There is a need to develop simple, noninvasive, and sensitive outcome measures for respiratory therapy. Adventitious respiratory sounds (ie, crackles and wheezes) can be objectively characterized with computerized respiratory sound analysis (CORSA) and have been shown to contribute for diagnosis purposes; ...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:10.4187/respcare.02765

    authors: Marques A,Oliveira A,Jácome C

    更新日期:2014-05-01 00:00:00