Analysis of gene expression profiles associated with glioma progression.

abstract：:Prostate carcinoma (PCa) is one of the most common cancers in men. Prostate-specific antigen (PSA) has been widely used to predict the outcome of PCa and screening with PSA has resulted in a decline in mortality. However, PSA is not an optimal prognostic tool as its sensitivity may be too low to reduce morbidity and m...

journal_title：Molecular medicine reports

authors： Hernandez-Cueto A,Hernandez-Cueto D,Antonio-Andres G,Mendoza-Marin M,Jimenez-Gutierrez C,Sandoval-Mejia AL,Mora-Campos R,Gonzalez-Bonilla C,Vega MI,Bonavida B,Huerta-Yepez S

更新日期：2014-11-01 00:00:00

abstract：:Chronic constipation (CC) is a highly prevalent heterogeneous disorder. Although CC is not known to be associated with the development of serious disease or with excess mortality, it considerably reduces the patients quality of life. In addition, it represents an economic burden to patients and society. The majority o...

journal_title：Molecular medicine reports

authors： El-Salhy M,Svensen R,Hatlebakk JG,Gilja OH,Hausken T

更新日期：2014-01-01 00:00:00

abstract：:As a member of the cysteine protease family, cathepsin S (CTSS) serves an important role in diseases such as cancer, arthritis and atherosclerosis. Nevertheless, its role in renal fibrosis is unknown. In the present study, the effects of CTSS on renal fibrosis in mild (group M) and severe (group S) hydronephrosis were...

journal_title：Molecular medicine reports

authors： Yao X,Cheng F,Yu W,Rao T,Li W,Zhao S,Zhou X,Ning J

更新日期：2019-07-01 00:00:00

abstract：:This study aimed to explore the effects of microbubble concentration, gene dosage, cell-microbubble mixing mode and fetal bovine serum (FBS) on gene delivery. 293T cells were transfected with Sonovue microbubbles carrying the hAng-1 gene via ultrasound irradiation. Various ultrasound exposure parameters and microbubbl...

journal_title：Molecular medicine reports

authors： Zhou Q,Chen JL,Chen Q,Wang X,Deng Q,Hu B,Guo RQ

更新日期：2012-12-01 00:00:00

abstract：:Angiogenesis requires the interaction of multiple variable factors to promote endothelial cell adhesion, migration and survival. Palmitate, a free fatty acid, exhibits an anti‑angiogenic effect via interference with endothelial cell function, whereas cysteine proteases are important in protein turnover and are termed ...

journal_title：Molecular medicine reports

authors： Zhang J,Shan Y,Li Y,Luo X,Shi H

更新日期：2017-06-01 00:00:00

abstract：:Polycystic ovarian syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenism and polycystic ovaries. To date, the molecular mechanisms underlying PCOS have remained to be fully elucidated. As recent studies have revealed a positive association between mitochondrial dysfunction and PCOS, current investi...

journal_title：Molecular medicine reports

authors： Ding Y,Zhuo G,Zhang C,Leng J

更新日期：2016-04-01 00:00:00

abstract：:Vitiligo is a polygenic autoimmune disorder characterized by loss of pigmentation due to melanocyte destruction. Hydroxychloroquine (HCQ) is an effective immunosuppressant widely used in the treatment of autoimmune disorders. As generalized vitiligo (GV) is commonly considered to be a T cell and autoantibody-induced i...

journal_title：Molecular medicine reports

authors： Li DG,Hu WZ,Ma HJ,Liu W,Yang QQ,Zhao G

更新日期：2016-08-01 00:00:00

abstract：:The chondrogenic differentiation of synovial mesenchymal stem cells (SMSCs) is regulated by essential transcription factors and signaling cascades. However, the precise mechanisms involved in this process remain unclear. MicroRNAs (miRs/miRNAs) are undersized non‑coding RNAs responsible for the post‑transcriptional re...

journal_title：Molecular medicine reports

authors： Cong R,Tao K,Fu P,Lou L,Zhu Y,Chen S,Cai X,Mao L

更新日期：2017-12-01 00:00:00

abstract：:1,2-Dimethylthdrazine (DMH) has been known to induce vascular neoplasms, such as malignant endothelioma, in animal experiments through the induction of abnormal proliferation of human umbilical vein endothelial cells (HUVECs). We studied the effect of protein kinase C (PKC) isoforms...

journal_title：Molecular medicine reports

authors： Nam S,Choi S,Lee J,Kim J,Song J,Bae Y

更新日期：2012-08-01 00:00:00

abstract：:para‑Phenylenediamine (p‑PD) is a potential carcinogen, and widely used in marketed hair dye formulations. In the present study, the role of the protein tyrosine kinase (PTK)/Ras/Raf/c‑Jun N‑terminal kinase (JNK) and phosphoinositide 3‑kinase (PI3k)/protein kinase B (Akt) pathways on the growth of NRK‑52E cells was in...

journal_title：Molecular medicine reports

authors： Kasi RA,Moi CS,Kien YW,Yian KR,Chin NW,Yen NK,Ponnudurai G,Fong SH

更新日期：2015-03-01 00:00:00

abstract：:The present study aimed to investigate genes and transcription factors (TFs) that may contribute to neuroblastoma (NB) development. The GSE78061 dataset that included 25 human NB cell lines and four retinal pigment epithelial cell lines was used to analyze differentially expressed genes (DEGs) between groups. Function...

journal_title：Molecular medicine reports

authors： Liu J,Li Y

更新日期：2019-10-01 00:00:00

abstract：:Hypoxia may induce apoptosis and autophagy to promote cardiomyocyte injury. The present study investigated the effect of berberine, a natural extract of Rhizoma Coptidis, on hypoxia‑induced autophagy and apoptosis in the H9c2 rat myocardial cell line. Expression levels of apoptosis and autophagy markers were upregulat...

journal_title：Molecular medicine reports

authors： Jia Z,Lin L,Huang S,Zhu Z,Huang W,Huang Z

更新日期：2017-08-01 00:00:00

abstract：:The present study aimed to investigate the clinical significance of histone methylation in sepsis. A total of 43 blood samples from trauma and esophageal cancer patients with or without sepsis were collected. Immunofluorescence staining of isolated peripheral white blood cells (WBCs) was conducted. Co‑stained 293T cel...

journal_title：Molecular medicine reports

authors： Jiang L,Wang Y,Zhu D,Xue Z,Mao H

更新日期：2016-12-01 00:00:00

abstract：:Pancreatic adenocarcinoma (PA) is a leading cause of adult cancer mortality, and surgery is still the best available treatment strategy. However, PA can recur at any time and has limited prognosis. It is therefore necessary to explore novel serum biomarkers of PA to allow the early diagnosis of PA. Soluble a-prolifera...

journal_title：Molecular medicine reports

authors： Han L,Zhang W,Song F,Guo Y,Guo K,Zhou W

更新日期：2014-10-01 00:00:00

abstract：:Potassium channels can be affected by epileptic seizures and serve a crucial role in the pathophysiology of epilepsy. Dimethylation of histone 3 lysine 9 (H3K9me2) and its enzyme euchromatic histone‑lysine N‑methyltransferase 2 (G9a) are the major epigenetic modulators and are associated with gene silencing. Insight i...

journal_title：Molecular medicine reports

authors： Zhang SP,Zhang M,Tao H,Luo Y,He T,Wang CH,Li XC,Chen L,Zhang LN,Sun T,Hu QK

更新日期：2018-01-01 00:00:00

abstract：:Bone cancer pain (BCP) is a severe complication of advanced bone cancer. Although cannabinoid receptor 2 (CB2) agonists may have an analgesic effect, the underlying mechanism remains unclear. CB2 serves a protective role in various pathological states through the activation of autophagy. Therefore, the present study a...

journal_title：Molecular medicine reports

authors： Mao Y,Huang Y,Zhang Y,Wang C,Wu H,Tian X,Liu Y,Hou B,Liang Y,Rong H,Gu X,Ma Z

更新日期：2019-12-01 00:00:00

abstract：:The aim of the present study was to explore the survival of pig-rhesus corneal xenografts following donor bone marrow transplantation (BMT). Wuzhishan pigs were used as donors and rhesus monkeys as recipients for corneal xenotransplantation. Twelve rhesus monkeys were divided into t...

journal_title：Molecular medicine reports

authors： Jie Y,Liu L,Pan Z,Wang L

更新日期：2013-03-01 00:00:00

abstract：:The aim of the present study was to analyze the protein composition of ductal breast carcinoma and the surrounding normal tissue in individual patients using comparative 2D proteomics and mass spectrometry to detect candidate disease biomarkers for diagnosis and prognosis. Samples of normal and cancerous tissue obtain...

journal_title：Molecular medicine reports

authors： Carcoforo P,Ura B,Mischiati C,Squerzanti M,Lanzara V,Cervellati C,Calza R,De Laureto PP,Frare E,Portinari M,Feriotto G,Lanzara S,Agostinelli E,Bergamini CM

更新日期：2013-05-01 00:00:00

abstract：:Socheongryeong‑tang (SCRT) is a herbal formula previously used to treat pulmonary diseases primarily caused by the common cold virus, including airway inflammation, asthma and allergy. The aim of the present study was to investigate the inhibitory effect of SCRT water extract and its 13 constituent components on chemo...

journal_title：Molecular medicine reports

authors： Kim JH,Jeon WY,Lee MY,Seo CS,Lim HS,Shin HK

更新日期：2014-12-01 00:00:00

abstract：:Thyroid stimulating hormone (TSH) consists of an α‑subunit and a unique β‑subunit. The first in‑frame TSHβ splice variant produced by the cells of immune system was identified in 2009. The TSHβ splice variant and native TSHβ exhibit different expression profiles, and research has been conducted to elucidate the role o...

journal_title：Molecular medicine reports

authors： Liu C,Miao J,Liu X,Zhao Z,Kou T,Liu J,Wang R,Li L,Dong Q

更新日期：2019-05-01 00:00:00

abstract：:Wnt/β-catenin signaling dysregulation is involved in tumorigenesis. Furthermore, epigenetic modification of the Dickkopf (DKK) family (DKK1‑4) has been shown to be important in the regulation of Wnt signaling. However, the functions and mechanism of DKK2 in the development and progression of prostate cancer remain unc...

journal_title：Molecular medicine reports

authors： Xu W,Pang K,Zhou ZG,Chen YF,Mo T,Li M,Liu CB

更新日期：2016-09-01 00:00:00

abstract：:Human adipose tissue stem cells (ATSCs) can differentiate into various types of cell in response to lineage-specific induction factors. Reprogramming cells using nuclear and cytoplasmic extracts derived from another type of somatic cell is an effective method of producing specific types of differentiated cell. In the ...

journal_title：Molecular medicine reports

authors： Xie F,Tang X,Zhang Q,Deng C

更新日期：2015-01-01 00:00:00

abstract：:Neutrophilic airway inflammation in chronic lung infections caused by Pseudomonas aeruginosa (PA) is associated with T helper (Th)17 responses. Suppressor of cytokine signaling 3 (SOCS3) is the major negative modulator of Th17 function through the suppression of signal transducer and activator of transcription (STAT)3...

journal_title：Molecular medicine reports

authors： Ding FM,Liao RM,Chen YQ,Xie GG,Zhang PY,Shao P,Zhang M

更新日期：2017-07-01 00:00:00

abstract：:Y‑box binding protein‑1 (YB‑1) has been identified as an oncoprotein in various malignancies. The aim of this study was to investigate the biological role of YB‑1 and its association with epithelial‑to‑mesenchymal transition (EMT) in colorectal cancer (CRC). The expression of YB‑1 and three EMT‑related proteins (E‑cad...

journal_title：Molecular medicine reports

authors： Yan XB,Zhu QC,Chen HQ,Peng JY,Chao HL,Du HX,Wang ZG,Jin ZM

更新日期：2014-11-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and malignant brain tumor of the adult central nervous system and is associated with poor prognosis. The present study aimed to identify the hub genes in GBM in order to improve the current understanding of the underlying mechanism of GBM. The RNA‑seq data were download...

journal_title：Molecular medicine reports

authors： Chen X,Pan Y,Yan M,Bao G,Sun X

更新日期：2020-08-01 00:00:00

abstract：:SRY-box 9 (SOX9) is an important transcription factor required for development, which has additionally been reported to be an independent prognostic indicator for the survival of patients with non‑small cell lung cancer (NSCLC). Accumulating evidence has indicated that dysregulation of microRNAs (miRNAs/miRs) may cont...

journal_title：Molecular medicine reports

authors： Lei Z,Shi H,Li W,Yu D,Shen F,Yu X,Lu D,Sun C,Liao K

更新日期：2018-01-01 00:00:00

abstract：:Cell division cycle 42 (CDC42), which is a member of the Rho GTPase family, has been reported to regulate the metastasis of various human cancer cells; however, the role of CDC42 in gastric cancer (GC) remains unclear. The present study aimed to investigate the effects of CDC42 on the proliferation, migration and inva...

journal_title：Molecular medicine reports

authors： Du DS,Yang XZ,Wang Q,Dai WJ,Kuai WX,Liu YL,Chu D,Tang XJ

更新日期：2016-01-01 00:00:00

abstract：:As the resident macrophages of the brain's innate immune system, microglial cells are key modulators in the neurodegenerative disease Alzheimer's disease (AD). In particular, the activation and accumulation of microglial cells around amyloid plaques is considered to result in chronic neuroinflammation. Although the pa...

journal_title：Molecular medicine reports

authors： Chen PL,Wang WJ,Rao YQ,Li J,Cheng MJ

更新日期：2018-04-01 00:00:00

abstract：:Spinal cord injury (SCI) is a cause of disability. The present study aimed to investigate the molecular mechanisms involved in traumatic SCI. Transcriptome data under accession no. GSE5296, including 96 chips, were downloaded from the Gene Expression Omnibus database. The raw data were normalized and differentially ex...

journal_title：Molecular medicine reports

authors： Zhao SJ,Zhou W,Chen J,Luo YJ,Yin GY

更新日期：2018-06-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) is considered to have a critical role in the occurrence and development of atherosclerosis in atherosclerosis-prone mice; however, it remains uncertain whether treatment with a TLR4 inhibitor may attenuate atherosclerosis. The present study aimed to determine the vascular protective effects...

journal_title：Molecular medicine reports

authors： Wang XQ,Wan HQ,Wei XJ,Zhang Y,Qu P

更新日期：2016-07-01 00:00:00