Medical management of patients on clozapine: A guide for internists.

Abstract:

:Clozapine was approved by the US Food and Drug Administration in 1989 for the management of treatment-resistant schizophrenia, and has since proven to reduce symptom burden and suicide risk, increase quality of life, and reduce substance use in individuals with psychotic disorders. Nevertheless, clozapine's psychiatric benefits have been matched by its adverse effect profile. Because they are likely to encounter medical complications of clozapine during admissions or consultations for other services, hospitalists are compelled to maintain an appreciation for these iatrogenic conditions. The authors outline common (eg, constipation, sialorrhea, weight gain) and serious (eg, agranulocytosis, seizures, myocarditis) medical complications of clozapine treatment, with internist-targeted recommendations for management, including indications for clozapine discontinuation.

journal_name

J Hosp Med

authors

Lundblad W,Azzam PN,Gopalan P,Ross CA

doi

10.1002/jhm.2345

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

537-43

issue

8

eissn

1553-5592

issn

1553-5606

journal_volume

10

pub_type

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