Abstract:
BACKGROUND:Meta-analyses of randomized trials have found that antibiotics are effective in acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but there is insufficient evidence to guide antibiotic selection. Current guidelines offer conflicting recommendations. OBJECTIVE:To compare the effectiveness of macrolides and quinolones for AECOPD DESIGN: Retrospective cohort study using logistic regression, propensity score-matching, and grouped treatment models. SETTING:A total of 375 acute care hospitals throughout the United States. PATIENTS:Age > or =40 years and hospitalized for AECOPD. INTERVENTION:Macrolide or quinolone antibiotic begun in the first 2 hospital days. MEASUREMENTS:Treatment failure (defined as the initiation of mechanical ventilation after hospital day 2, inpatient mortality, or readmission for AECOPD within 30 days), length of stay, and hospital costs. RESULTS:Of the 19,608 patients who met the inclusion criteria, 6139 (31%) were treated initially with a macrolide and 13,469 (69%) with a quinolone. Compared to patients treated initially with a quinolone, those who received macrolides had a lower risk of treatment failure (6.8% vs. 8.1%; P < 0.01), a finding that was attenuated after multivariable adjustment (odds ratio [OR], 0.89; 95% confidence interval [CI], 0.78-1.01), and disappeared in a grouped-treatment analysis (OR, 1.01; 95% CI, 0.75-1.35). There were no differences in adjusted length of stay (ratio, 0.98; 95% CI, 0.97-1.00) or adjusted cost (ratio, 1.00; 95% CI, 0.99-1.02). After propensity score-matching, antibiotic-associated diarrhea was more common with quinolones (1.2% vs. 0.6%; P < 0.001). CONCLUSIONS:Macrolide and quinolone antibiotics are associated with similar rates of treatment failure in AECOPD; however, macrolides are less frequently associated with diarrhea.
journal_name
J Hosp Medjournal_title
Journal of hospital medicineauthors
Rothberg MB,Pekow PS,Lahti M,Brody O,Skiest DJ,Lindenauer PKdoi
10.1002/jhm.628subject
Has Abstractpub_date
2010-05-01 00:00:00pages
261-7issue
5eissn
1553-5592issn
1553-5606journal_volume
5pub_type
杂志文章,多中心研究abstract:BACKGROUND:Despite safe and cost-effective venous thromboembolism (VTE) prevention measures, VTE prophylaxis rates are often suboptimal. Healthcare reform efforts emphasize transparency through programs to report performance and payment incentives through pay-for-performance programs. OBJECTIVE:To sequentially examine...
journal_title:Journal of hospital medicine
pub_type: 杂志文章
doi:10.1002/jhm.2303
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Although severity of illness indices such as pneumonia severity index (PSI) are good predictors of short-term mortality for community-acquired pneumonia (CAP) and healthcare-associated pneumonia (HCAP), other patient factors may have added prognostic value. OBJECTIVE:To identify patient factors beyond the P...
journal_title:Journal of hospital medicine
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:The Centers for Disease Control and Prevention recommends routinely offering HIV testing to inpatients at hospitals with an HIV seroprevalence rate of greater than 1% or an AIDS diagnosis rate of greater than 1.0 per 1000 discharges. This recommendation has not been widely adopted, perhaps because of one of ...
journal_title:Journal of hospital medicine
pub_type: 杂志文章,评审
doi:10.1002/jhm.66
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Cognitive errors in the course of clinical decision-making are prevalent in many cases of medical injury. We used information on verdict's judgment from closed claims files to determine the important cognitive factors associated with cases of medical injury. METHODS:Data were collected from claims closed be...
journal_title:Journal of hospital medicine
pub_type: 杂志文章
doi:10.1002/jhm.820
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Knowing the number of discharges that will occur is important for administrators when hospital occupancy is close to or exceeds 100%. This information will facilitate decision making such as whether to bring in extra staff, cancel planned surgery, or implement measures to increase the number of discharges. W...
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pub_type: 杂志文章
doi:10.12788/jhm.2802
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Little is known about management of hyperglycemia in inpatients. OBJECTIVE:To gain insight into caring for hospitalized patients with hyperglycemia. DESIGN:Retrospective analysis. SETTING:Teaching hospital. PATIENTS:Data on all patients discharged between January 1, 2001, and December 31, 2004 with a dia...
journal_title:Journal of hospital medicine
pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
abstract::For more than 20 years, the Agency for Healthcare Research and Quality (AHRQ) Evidence-based Practice Center (EPC) Program has been identifying and synthesizing evidence to inform evidence-based healthcare. Recognizing that many healthcare settings continue to face challenges in disseminating and implementing evidence...
journal_title:Journal of hospital medicine
pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Computerized clinical knowledge mana-gement systems hold enormous potential for improving quality and efficiency. However, their impact on clinical practice is not well known. OBJECTIVE:To examine the impact of UpToDate on outcomes of care. DESIGN:Retrospective study. SETTING:National sample of US inpatie...
journal_title:Journal of hospital medicine
pub_type: 杂志文章
doi:10.1002/jhm.944
更新日期:2012-02-01 00:00:00
abstract::Value-based payment systems have been widely implemented in healthcare in an effort to improve the quality of care. However, these programs have not broadly improved quality, and some evidence suggests that they may increase inequities in care. No Child Left Behind is a parallel effort in education to address uneven a...
journal_title:Journal of hospital medicine
pub_type: 杂志文章
doi:10.1002/jhm.2483
更新日期:2016-01-01 00:00:00
abstract::Increasing numbers of serious hospital/healthcare- or community-acquired infections are caused by resistant (often multi-drug resistant) bacterial pathogens. Because delayed or ineffective initial therapy can have severe negative consequences, patients at risk for these types of infections typically receive initial em...
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更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Recent studies in the outpatient setting have demonstrated high rates of opioid prescribing and overdose-related deaths. Prescribing practices in hospitalized patients are unexamined. OBJECTIVE:To investigate patterns and predictors of opioid utilization in nonsurgical admissions to US hospitals, variation ...
journal_title:Journal of hospital medicine
pub_type: 杂志文章
doi:10.1002/jhm.2102
更新日期:2014-02-01 00:00:00
abstract::Dysphagia is associated with aspiration, pneumonia, and malnutrition, but remains challenging to identify at the bedside. A variety of exam protocols and maneuvers are commonly used, but the efficacy of these maneuvers is highly variable. We conducted a comprehensive search of 7 databases, including MEDLINE, Embase, a...
journal_title:Journal of hospital medicine
pub_type: 杂志文章,评审
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更新日期:2015-04-01 00:00:00
abstract::Every year, nearly 5 million adults with cancer are hospitalized. Limited evidence suggests that hospitalization of the cancer patient is associated with adverse morbidity and mortality. Hospitalization of the patient with advanced cancer allows for an intense examination of health status in the face of terminal illne...
journal_title:Journal of hospital medicine
pub_type: 杂志文章,评审
doi:10.1002/jhm.2511
更新日期:2016-04-01 00:00:00
abstract::Outcomes for patients hospitalized on weekends are often worse for adults-the so-called "weekend effect." Less is known about the weekend effect for children. We examined 55,383 hospitalizations at a tertiary care children's hospital. We used logistic regression to examine the associations of weekend admission and wee...
journal_title:Journal of hospital medicine
pub_type: 杂志文章
doi:10.1002/jhm.2426
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:Guidelines recommend pharmacologic prophylaxis for hospitalized medical patients at increased risk of thromboembolism. Despite recommendations, multiple studies demonstrate underutilization. Factors contributing to underutilization include uncertainty that prophylaxis reduces clinically relevant events, as w...
journal_title:Journal of hospital medicine
pub_type: 杂志文章,meta分析
doi:10.1002/jhm.450
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:Mortality in hospitalized human immunodeficiency virus (HIV)-infected patients is not well described. We sought to characterize in-hospital deaths among HIV-infected patients in the antiretroviral (ART) era and identify factors associated with mortality. METHODS:We reviewed the medical records of hospitalize...
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doi:10.1002/jhm.2409
更新日期:2015-09-01 00:00:00
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journal_title:Journal of hospital medicine
pub_type: 杂志文章
doi:10.1002/jhm.2446
更新日期:2016-01-01 00:00:00
abstract::Clozapine was approved by the US Food and Drug Administration in 1989 for the management of treatment-resistant schizophrenia, and has since proven to reduce symptom burden and suicide risk, increase quality of life, and reduce substance use in individuals with psychotic disorders. Nevertheless, clozapine's psychiatri...
journal_title:Journal of hospital medicine
pub_type: 杂志文章,评审
doi:10.1002/jhm.2345
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Hospital leaders have had mixed success reducing readmissions Little is known about the readmitted patient's perspective. METHODS:A cross-sectional 36-item survey was administered to 1084 readmitted inpatients of The Hospital of the University of Pennsylvania (an urban academic medical center) and Penn Pres...
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pub_type: 杂志文章
doi:10.1002/jhm.1966
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To develop a valid instrument to assess morale and explore the relationship between morale and intent to leave employment due to unhappiness. PATIENTS AND METHODS:An expert panel identified 46 drivers of hospitalist morale. In May 2009, responders of our single-site pilot survey rated each driver in terms of...
journal_title:Journal of hospital medicine
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更新日期:2016-06-01 00:00:00
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abstract:: ...
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pub_type: 评论,社论
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journal_title:Journal of hospital medicine
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
abstract::Esophageal variceal bleeding (EVB) is a frequent complication in cirrhotic patients resulting in considerable mortality and morbidity. The aim of this study was to investigate the occurrence, impact, and trends of EVB in hospitalized cirrhotic patients on a nationwide level in the United States. We interrogated data f...
journal_title:Journal of hospital medicine
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Readmission to a different hospital than the original discharge hospital may result in breakdowns in continuity of care. In different-hospital readmissions (DHRs), continuity can be maintained when hospitals are connected through health information exchange (HIE) systems. OBJECTIVE:To examine whether length...
journal_title:Journal of hospital medicine
pub_type: 杂志文章
doi:10.1002/jhm.2535
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Emergency department (ED) ward admissions subsequently transferred to the intensive care unit (ICU) within 24 hours have higher mortality than direct ICU admissions. DESIGN, SETTING, PATIENTS:Describe risk factors for unplanned ICU transfer within 24 hours of ward arrival from the ED. METHODS:Evaluation of...
journal_title:Journal of hospital medicine
pub_type: 杂志文章
doi:10.1002/jhm.1979
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE: DESIGN: SETTING: PATIENTS: MEASUREMENTS: RESULTS: CONCLUSIONS: ...
journal_title:Journal of hospital medicine
pub_type: 评论,信件
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更新日期:2018-11-01 00:00:00
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journal_title:Journal of hospital medicine
pub_type: 社论
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更新日期:2012-03-01 00:00:00