Fungispecificity of fluconazole against Candida albicans.

Abstract:

:Candida albicans is an opportunistic pathogen of human mucosal surfaces. Colonization of oral and vaginal mucosa by this yeast is antagonized by the resident normal bacterial population. However, antibacterial therapy can alter the normal flora to allow fungal cells to attach, grow and invade host tissues. We studied the antimicrobic activity of fluconazole against clinical isolates of oral and vaginal bacteria and Candida albicans in vitro and in vivo by scanning and transmission electron microscopy; we also compared the bactericidal activity of fluconazole with clotrimazole in vitro by microbiologic assay. Fluconazole lysed fungi but did not change the ultrastructure of bacteria. Clotrimazole, but not fluconazole, was bactericidal against lactobacillus and streptococcus, the principal species of the oral and vaginal cavities. We conclude that Candida albicans, but not oral and vaginal bacteria, is susceptible to fluconazole. These observations help explain the antimycotic specificity of fluconazole and its efficacy against candidiasis in humans.

journal_name

Mycopathologia

journal_title

Mycopathologia

authors

Liss RH,Letourneau RJ

doi

10.1007/BF00436222

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

173-8

issue

3

eissn

0301-486X

issn

1573-0832

journal_volume

108

pub_type

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