Abstract:
:Bilateral chylothorax is a rare cause of pleural effusions. Here we report an unusual acute presentation of bilateral chylothorax following thoracic outlet surgery. Unique to this case was the disparate characteristics of pleural fluid analyses with an exudate on the left and a transudate on the right. This report describes the recognition and management of bilateral chylothoraces, an uncommon but potentially serious complication of this frequently performed surgical procedure.
journal_name
Ther Adv Chronic Disjournal_title
Therapeutic advances in chronic diseaseauthors
Morjaria JB,Aslam I,Johnson B,Greenstone MA,Kastelik JAdoi
10.1177/2040622314552072subject
Has Abstractpub_date
2015-01-01 00:00:00pages
29-33issue
1eissn
2040-6223issn
2040-6231pii
10.1177_2040622314552072journal_volume
6pub_type
杂志文章,评审abstract:Background:Pemphigus vulgaris (PV) is a potentially life-threatening mucocutaneous autoimmune blistering disease characterized by suprabasal acantholysis, causing painful mucocutaneous blisters and erosions. Current mainstay therapy for pemphigus is systemic corticosteroids in combination with or without immunosuppress...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622320916023
更新日期:2020-05-02 00:00:00
abstract:Background:Chronic inflammation in rheumatoid arthritis (RA) can induce reduced muscle mass (myopenia) and ectopic fat deposition probably showing normal body mass index (BMI). We aimed to investigate their body composition (BC) characteristics and clinical significance. Methods:BMI and BC were collected in consecutiv...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622320975241
更新日期:2020-11-27 00:00:00
abstract::"Ivy sign" is a special imaging manifestation of moyamoya disease (MMD), which shows continuous linear or punctate high intensity along the cortical sulci and subarachnoid space on magnetic resonance images. Ivy sign was reported to reflect the development of compensatory collaterals, and to be closely related to hemo...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章,评审
doi:10.1177/2040622320960004
更新日期:2020-10-10 00:00:00
abstract:Background:A recently developed global indicator of oxidative stress (OXY-SCORE), by combining individual plasma biomarkers of oxidative damage and antioxidant capacity, has been validated in several pathologies, but not in left ventricular hypertrophy (LVH). The aim of this study was to design and calculate a plasma o...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622320936417
更新日期:2020-06-27 00:00:00
abstract::Large numbers of frail elderly people spend some time of their lives in care homes. Increasing age is associated with altered physiology, multiple diagnoses and complex comorbidity, and polypharmacy. Those living in care homes often take larger numbers of medications than those who live in the community and the risk o...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622311421438
更新日期:2011-11-01 00:00:00
abstract::Psoriasis is a chronic inflammatory disorder that is clinically characterized by scaly cutaneous plaques. New evidence suggests that dysregulation of interleukin (IL)-23, a key cytokine in the T-helper-17 pathway, plays a vital role in the development of psoriatic systemic inflammation. The novel biologic medication t...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章,评审
doi:10.1177/2040622319865658
更新日期:2019-08-12 00:00:00
abstract::In patients affected by chronic hepatitis C (CHC) infection, viral eradication can be achieved by antiviral therapy based on the use of a combination of pegylated interferon α-2a or 2b and ribavirin that yields a sustained eradication in 40-50% of cases. The aim of this review is to evaluate the efficacy of pegylated ...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622310384308
更新日期:2011-01-01 00:00:00
abstract::Intravenous iron has been considered dangerous by many clinicians. In the last two decades, considerable experience has been gained with new formulations in different clinical settings. Data from clinical trials, observational studies, and postmarketing surveillance studies demonstrate that intravenous iron is safe an...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622310373675
更新日期:2010-03-01 00:00:00
abstract::Dual antiplatelet therapy (DAPT), which includes the combination of aspirin and a P2Y12 platelet receptor inhibitor, is a well-established antiplatelet regimen in the treatment of patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Three P2Y12 inhibitor options (clopidogrel, prasugrel and ticagr...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章,评审
doi:10.1177/2040622315584113
更新日期:2015-07-01 00:00:00
abstract::The objective of this review was to explore the efficacy of angiotensin II receptor blockers (ARBs) for the treatment of hyperuricemia in individuals diagnosed with gout or hyperuricemia defined as ⩾7 mg/dl at baseline. A literature search of MEDLINE (1946 to June 2015) and EMBASE (1947 to June 2015) was conducted. Th...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章,评审
doi:10.1177/2040622315596119
更新日期:2015-11-01 00:00:00
abstract::Oesophageal physiology testing plays an important role in the diagnosis of noncardiac chest pain (NCCP) after cardiac, structural and mucosal abnormalities have been ruled out. Endoscopy can establish the presence of structural causes of chest pain such as cancer, oesophageal webs and diverticula. Even if macroscopica...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章,评审
doi:10.1177/2040622318791392
更新日期:2018-09-11 00:00:00
abstract:Background:Hepatic fibrosis is the result of chronic liver injury that can progress to cirrhosis and lead to liver failure. Nevertheless, there are no anti-fibrotic drugs licensed for human use. Here, we investigated the anti-fibrotic activity of GNS561, a new lysosomotropic molecule with high liver tropism. Methods:T...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622320942042
更新日期:2020-07-16 00:00:00
abstract::The common pathological mechanisms among the spectrum of neurodegenerative diseases are supposed to be shared. Multiple lines of evidence, from molecular and cellular to epidemiological, have implicated nicotinic transmission in the pathology of the two most common neurodegenerative disorders, namely Alzheimer's disea...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622310397691
更新日期:2011-05-01 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive parenchymal lung disease characterized by a median survival of 3-5 years following diagnosis. The diagnosis is based on clinical, radiological and histopathological evaluation. Therefore, a multidisciplinary team is needed to reach the correct diagnosis. Fo...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章,评审
doi:10.1177/2040622315624276
更新日期:2016-03-01 00:00:00
abstract::Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that progresses to end-stage liver disease and cirrhosis. Recurrent biliary inflammation is thought to lead to dysplasia, and as such PSC confers a high risk of cholangiocarcinoma. PSC accounts for 10% of all UK liver transplants, although tra...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章,评审
doi:10.1177/2040622315605821
更新日期:2016-01-01 00:00:00
abstract::Heart failure represents a major global cause of morbidity and mortality. Ivabradine is a selective funny current (If) inhibitor, which acts on the sinoatrial node, resulting in a reduction in heart rate. Ivabradine is currently licensed for use in patients with symptomatic heart failure with reduced ejection fraction...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章,评审
doi:10.1177/2040622318784556
更新日期:2018-07-04 00:00:00
abstract::Dipeptidyl peptidase IV (DPP-4), an incretin glucagon-like peptide-1 (GLP-1) degrading enzyme, contains two forms and it can exert various physiological functions particular in controlling blood glucose through the action of GLP-1. In diabetic use, the DPP-4 inhibitor can block the DDP-4 to attenuate GLP-1 degradation...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章,评审
doi:10.1177/2040622319875305
更新日期:2019-09-19 00:00:00
abstract::Dimethyl fumarate (DMF) is one of the newer additions to the armamentarium of potent immunomodulators for the treatment of relapsing-remitting multiple sclerosis (RRMS). After more than 2 years of real-world experience and more than 190,000 patients currently treated with DMF worldwide, it is a good timepoint to revie...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章,评审
doi:10.1177/2040622316653307
更新日期:2016-07-01 00:00:00
abstract::Acute diverticulitis of the colon represents a significant burden for national health systems, in terms of direct and indirect costs. Past guidelines claimed that recurrent episodes (two or more) of diverticulitis need surgery, but revised guidelines recommend an individualized approach to patients after an attack of ...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622313498809
更新日期:2013-11-01 00:00:00
abstract::A growing body of scientific studies show that e-cigarettes may serve as an acceptable substitute for smoking tobacco cigarettes, thereby reducing or eliminating exposure to harmful elements in smoke. The success of e-cigarettes is such that sales of these products are rapidly gaining on traditional cigarettes. The ra...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章,评审
doi:10.1177/2040622314521271
更新日期:2014-03-01 00:00:00
abstract:Background:Lyme disease (LD) is a tick-borne infection caused by Borrelia burgdorferi sensu lato. The current therapeutic approach to this disease is limited to antibiotics. However, after their administration, about 20% of patients experience delayed onset of this illness manifesting as lingering persistent symptoms. ...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622320922005
更新日期:2020-05-24 00:00:00
abstract::The effect of shortening the pulse width of the electrical stimulus when administering electroconvulsive therapy (ECT) has recently been systematically studied with promising results. This review examines reported outcomes from three randomized controlled trials which compared ultrabrief (≤0.3 ms) with brief (0.5-1.5 ...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622311432493
更新日期:2012-03-01 00:00:00
abstract::In the last decade, there have been a number of significant advances made in the field of rare bone diseases. In this review, we discuss the expansion of the classification system for osteogenesis imperfecta (OI) and the resultant increase in therapeutic options available for management of OI. Bisphosphonates remain t...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章,评审
doi:10.1177/2040622317739538
更新日期:2018-01-01 00:00:00
abstract::Plaque psoriasis is one of the most common autoimmune skin diseases and is characterized by erythematous, scaly plaques. Many highly effective, targeted therapies have been developed as a result of an improved understanding of the pathogenesis of psoriasis. Using agents that target the central interleukin (IL)-23/IL-1...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622318759282
更新日期:2018-05-01 00:00:00
abstract::Psoriatic arthritis is a common systemic inflammatory disorder, which in addition to skin and nail involvement may be associated with peripheral and axial joint involvement, enthesitis, dactylitis, and important comorbidities - especially cardiovascular morbidity. Better insights into the involved pathogenic mechanism...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622312459673
更新日期:2012-11-01 00:00:00
abstract::Immunosuppressive therapy is frequently used to treat gastrointestinal diseases such as inflammatory bowel disease, autoimmune hepatitis, IgG4-related disease (autoimmune pancreatitis and sclerosing cholangitis) and in the post-transplantation setting. These drugs interfere with the immune system. The main safety conc...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622313485275
更新日期:2013-07-01 00:00:00
abstract:Background:We aimed to determine the role of non-mydriatic fundus examination and artificial intelligence (AI) in screening diabetic retinopathy (DR) in patients with diabetes in the Metabolic Disease Management Center (MMC) in Tianjin, China. Methods:Adult patients with type 2 diabetes mellitus who were first treated...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622320942415
更新日期:2020-09-10 00:00:00
abstract:Bacground:The aim of this study was to conduct a meta-analysis to compare the overall intraocular pressure (IOP)-lowering effect of iStent or CyPass as isolated procedures or in combination with cataract extraction. Materials and methods:Cochrane review manager 5.3 software (RevMan® 5.3) was used for a meta-analysis o...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622318820850
更新日期:2019-01-31 00:00:00
abstract:Background and objective:The term 'fibroblast' covers a heterogeneous cell population in idiopathic pulmonary fibrosis (IPF). The fibroblasts are considered as main effector cells, because they promote disease progression by releasing exaggerated amounts of extracellular matrix proteins and modifying cell microenvironm...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章
doi:10.1177/2040622320936023
更新日期:2020-06-24 00:00:00
abstract::Secreted frizzled-related proteins (Sfrps) are a family of secreted proteins that bind extracellularly to Wnt ligands and frizzled receptors. This binding modulates the Wnt signaling cascade, and Sfrps interact with their corresponding receptors. Sfrps are thought to play an important role in the pathological mechanis...
journal_title:Therapeutic advances in chronic disease
pub_type: 杂志文章,评审
doi:10.1177/2040622320901990
更新日期:2020-01-28 00:00:00