Role of Sfrps in cardiovascular disease.

Abstract:

:Secreted frizzled-related proteins (Sfrps) are a family of secreted proteins that bind extracellularly to Wnt ligands and frizzled receptors. This binding modulates the Wnt signaling cascade, and Sfrps interact with their corresponding receptors. Sfrps are thought to play an important role in the pathological mechanism of cardiac disease such as myocardial infarction, cardiac remodeling, and heart failure. However, the overall role of Sfrps in cardiac disease is unknown. Some members of the Sfrps family modulate cellular apoptosis, angiogenesis, differentiation, the inflammatory process, and cardiac remodeling. In this review, we summarize the evidence of Sfrps association with cardiac disease. We also discuss how multiple mechanisms may underlie Sfrps being involved in such diverse pathologies.

journal_name

Ther Adv Chronic Dis

authors

Huang A,Huang Y

doi

10.1177/2040622320901990

subject

Has Abstract

pub_date

2020-01-28 00:00:00

pages

2040622320901990

eissn

2040-6223

issn

2040-6231

pii

10.1177_2040622320901990

journal_volume

11

pub_type

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