KRAS mutation testing in clinical practice.

Abstract:

:Activating mutation of KRAS plays a significant role in the pathogenesis of common human malignancies and molecular testing of KRAS mutation has emerged as an essential biomarker in the current practice of clinical oncology. The presence of KRAS mutation is generally associated with clinical aggressiveness of the cancer and reduced survival of the patient. Therapeutically, KRAS mutation testing has maximum utility in stratifying metastatic colorectal carcinoma and lung cancer patients for treatment with targeted therapy. Diagnostically, KRAS mutation testing is useful in the workup of pancreaticobiliary and thyroid cancers, particularly using cytological specimens. In the era of precision medicine, the role of KRAS mutation testing is poised to expand, likely in a setting of combinatorial therapeutic strategy and requiring additional mutation testing of its upstream and/or downstream effectors.

journal_name

Expert Rev Mol Diagn

authors

Perincheri S,Hui P

doi

10.1586/14737159.2015.986102

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

375-84

issue

3

eissn

1473-7159

issn

1744-8352

journal_volume

15

pub_type

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