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Microstructure of frontoparietal connections predicts individual resistance to sleep deprivation.

Abstract：

:Sleep deprivation (SD) can degrade cognitive functioning, but growing evidence suggests that there are large individual differences in the vulnerability to this effect. Some evidence suggests that baseline differences in the responsiveness of a fronto-parietal attention system that is activated during working memory (WM) tasks may be associated with the ability to sustain vigilance during sleep deprivation. However, the neurocircuitry underlying this network remains virtually unexplored. In this study, we employed diffusion tensor imaging (DTI) to investigate the association between the microstructure of the axonal pathway connecting the frontal and parietal regions--i.e., the superior longitudinal fasciculus (SLF)--and individual resistance to SD. Thirty healthy participants (15 males) aged 20-43 years underwent functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) at rested wakefulness prior to a 28-hour period of SD. Task-related fronto-parietal fMRI activation clusters during a Sternberg WM Task were localized and used as seed regions for probabilistic fiber tractography. DTI metrics, including fractional anisotropy, mean diffusivity, axial and radial diffusivity were measured in the SLF. The psychomotor vigilance test (PVT) was used to evaluate resistance to SD. We found that activation in the left inferior parietal lobule (IPL) and dorsolateral prefrontal cortex (DLPFC) positively correlated with resistance. Higher fractional anisotropy of the left SLF comprising the primary axons connecting IPL and DLPFC was also associated with better resistance. These findings suggest that individual differences in resistance to SD are associated with the functional responsiveness of a fronto-parietal attention system and the microstructural properties of the axonal interconnections.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Cui J,Tkachenko O,Gogel H,Kipman M,Preer LA,Weber M,Divatia SC,Demers LA,Olson EA,Buchholz JL,Bark JS,Rosso IM,Rauch SL,Killgore WD

doi

10.1016/j.neuroimage.2014.11.035

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

123-33

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(14)00952-5

journal_volume

106

pub_type

杂志文章,随机对照试验

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Microstructure of frontoparietal connections predicts individual resistance to sleep deprivation.