Ascorbic acid iontophoresis for chondral gain in rats with arthritis.

Abstract:

OBJECTIVES:To examine the cellularity and thickness of the articular cartilage of the femur in rats with arthritis after treatment with iontophoresis. METHODS:To evaluate these objectives, a histological analysis was performed on hematoxylin and eosin, where cellularity and cartilage thickness were observed and evaluated qualitatively and quantitatively by manual counting by 700.09µm² area. RESULTS:The group treated with IAA had normal cellularity (40.1 cells/μm(2)) and maintenance of non-calcified cartilage (75.5μm), suggesting normal thickness. The non-treated group C+, on the other hand, had a lower mean number of chondrocytes (13.0μm(2)) (P <0.05) and, when the cartilage thickness was compared, it showed higher average thickness of calcified cartilage (104.8 mm) and lower mean of non-calcified cartilage (53.3μm). CONCLUSION:The use of iontophoresis with L-ascorbic acid by continuous electric current contributed to a quantitative gain of chondrocytes and improved the thickness distribution of calcified and non-calcified cartilage. Level of Evidence III, Case Control Study.

journal_name

Acta Ortop Bras

authors

de Arruda MF,Cassettari LL,Neves LM,Oliveira OM,Marcolino AM

doi

10.1590/1413-78522014220400769

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

202-5

issue

4

eissn

1413-7852

issn

1809-4406

journal_volume

22

pub_type

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