Liver functions in silica-exposed workers in Egypt: possible role of matrix remodeling and immunological factors.

Abstract:

BACKGROUND:Brick manufacturing constitutes an important industrial sector in Egypt with considerable exposure to silica. OBJECTIVES:We aimed for evaluating hepatic functions in silica-exposed workers in the clay brick industry, and the possible role of matrix remodeling and immunological factors. METHODS:A case-control study, 87 workers as exposed and 45 as control subjects. Questionnaire, clinical examination, and laboratory investigations: liver functions, matrix metalloproteinase-9, immunoglobulins G and E, and anti-liver kidney microsomal antibody. RESULTS:In the exposed workers, mean levels of liver functions, matrix metalloproteinase-9 (MMP-9), and IgG and IgE were significantly higher. In the silicotic subgroup the mean level of GGT was almost twice the level in the non-silicotic subjects. Logistic regression showed that abnormal GGT and ALT were associated with production workers. CONCLUSION:Workers in the clay brick industry showed evidence of liver disease that could be related to matrix remodeling.

authors

Zawilla N,Taha F,Ibrahim Y

doi

10.1179/2049396714Y.0000000061

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

146-56

issue

2

eissn

1077-3525

issn

2049-3967

journal_volume

20

pub_type

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