Abstract:
BACKGROUND:Brick manufacturing constitutes an important industrial sector in Egypt with considerable exposure to silica. OBJECTIVES:We aimed for evaluating hepatic functions in silica-exposed workers in the clay brick industry, and the possible role of matrix remodeling and immunological factors. METHODS:A case-control study, 87 workers as exposed and 45 as control subjects. Questionnaire, clinical examination, and laboratory investigations: liver functions, matrix metalloproteinase-9, immunoglobulins G and E, and anti-liver kidney microsomal antibody. RESULTS:In the exposed workers, mean levels of liver functions, matrix metalloproteinase-9 (MMP-9), and IgG and IgE were significantly higher. In the silicotic subgroup the mean level of GGT was almost twice the level in the non-silicotic subjects. Logistic regression showed that abnormal GGT and ALT were associated with production workers. CONCLUSION:Workers in the clay brick industry showed evidence of liver disease that could be related to matrix remodeling.
journal_name
Int J Occup Environ Healthauthors
Zawilla N,Taha F,Ibrahim Ydoi
10.1179/2049396714Y.0000000061subject
Has Abstractpub_date
2014-04-01 00:00:00pages
146-56issue
2eissn
1077-3525issn
2049-3967journal_volume
20pub_type
杂志文章abstract::Health effects of occupational exposures are frequently evaluated by comparing the mortality of a whole cohort of workers with that of the general population. This study design may be affected by two major biases: a dilution effect (DE), due to the inclusion of unexposed subjects in the study cohort, and a comparison ...
journal_title:International journal of occupational and environmental health
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