Re-thinking the role of motor cortex: context-sensitive motor outputs?

Abstract:

:The standard account of motor control considers descending outputs from primary motor cortex (M1) as motor commands and efference copy. This account has been challenged recently by an alternative formulation in terms of active inference: M1 is considered as part of a sensorimotor hierarchy providing top-down proprioceptive predictions. The key difference between these accounts is that predictions are sensitive to the current proprioceptive context, whereas efference copy is not. Using functional electric stimulation to experimentally manipulate proprioception during voluntary movement in healthy human subjects, we assessed the evidence for context sensitive output from M1. Dynamic causal modeling of functional magnetic resonance imaging responses showed that FES altered proprioception increased the influence of M1 on primary somatosensory cortex (S1). These results disambiguate competing accounts of motor control, provide some insight into the synaptic mechanisms of sensory attenuation and may speak to potential mechanisms of action of FES in promoting motor learning in neurorehabilitation.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Gandolla M,Ferrante S,Molteni F,Guanziroli E,Frattini T,Martegani A,Ferrigno G,Friston K,Pedrocchi A,Ward NS

doi

10.1016/j.neuroimage.2014.01.011

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

366-74

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(14)00022-6

journal_volume

91

pub_type

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