Abstract:
:Inflammatory response is a major defense mechanism against pathogens and chemical or mechanical injury. Rhus verniciflua Stokes (RVS) has traditionally been used as an ingredient in East Asian medicine for the treatment of gastritis, stomach cancer and atherosclerosis. The aim of the current study was to analyze the effect of RVS on LPS‑induced inflammatory responses in the RAW264.7 mouse macrophage cell line. RAW264.7 cells were treated with various concentrations of RVS and LPS at specific time points. WST assay, trypan blue assay and quantification of activated cells revealed that RVS suppressed cell proliferation in a dose‑dependent manner. RVS induced G1 cell cycle arrest, suppressed iNOS and COX‑2 mRNA expression induced by LPS and decreased intracellular ROS levels induced by LPS. In addition, RVS induced PARP and caspase‑3 cleavage suggesting that RVS causes cell death. Results of the present study indicate that RVS may be advantageous in treating inflammatory disease.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Choi HS,Seo HS,Kim SR,Choi YK,Jang BH,Shin YC,Ko SGdoi
10.3892/mmr.2013.1775subject
Has Abstractpub_date
2014-01-01 00:00:00pages
311-5issue
1eissn
1791-2997issn
1791-3004journal_volume
9pub_type
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