Abstract:
:Interleukin (IL)-33 is an important mediator of innate immunity. Behcet's disease (BD) is an autoinflammatory disorder characterized by hyperactivity of the innate immune response. We measured serum levels of IL-33 and its receptor soluble ST2 (sST2) in patients with BD to investigate their association with disease activity. Serum levels of both IL-33 and sST2 were higher in patients with BD compared with those in normal controls (IL-33: 594.48±175.04 pg/mL in BD and 224.23±56.64 pg/mL in normal controls [P=0.048], sST2: 99.01±15.92 pg/mL in BD and 23.56±3.25 pg/mL in normal controls [P<0.001]). IL-33 and sST2 expression in skin tissue, as shown by immunohistochemistry, was higher in patients with BD compared with that in the normal controls. Serum sST2 level correlated significantly with the BD currently active form (BDCAF), Iranian BD dynamic activity measure (IBDDAM), erythrocyte sedimentation rate and C-reactive protein. Multiple linear regression showed that serum sST2 was an independent factor associated with IBBDAM (regression coefficient, 0.374; P=0.004), and BDCAF (regression coefficient, 0.236; P=0.047). These results demonstrate that IL-33 and sST2 are highly expressed in patients with BD and that serum sST2 is an independent factor associated with IBDDAM and BDCAF, suggesting a potential role for sST2 as a surrogate marker of disease activity in patients with BD.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Kim DJ,Baek SY,Park MK,Park KS,Lee JH,Park SH,Kim HY,Kwok SKdoi
10.3346/jkms.2013.28.8.1145subject
Has Abstractpub_date
2013-08-01 00:00:00pages
1145-53issue
8eissn
1011-8934issn
1598-6357journal_volume
28pub_type
杂志文章abstract::This study investigated whether tempol, an anti-oxidant, protects against renal injury by modulating phosphatidylinositol 3-kinase (PI3K)-Akt-Forkhead homeobox O (FoxO) signaling. Mice received unilateral ureteral obstruction (UUO) surgery with or without administration of tempol. We evaluated renal damage, oxidative ...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2014.29.2.230
更新日期:2014-02-01 00:00:00
abstract::We report a case of huge pulmonary chondroid hamartoma with multilocular cysts in a 38-yr-old male patient. The lobectomy specimen of the left lower lobe showed a large multilocular cystic mass, 11.5 x 10 cm in size. The mass had thin-walled, variable-sized cysts and areas of solid cartilaginous small nodules in the i...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2005.20.3.509
更新日期:2005-06-01 00:00:00
abstract::The objective of this study was to develop a Korean version of the Assessment of Spondyloarthritis International Society-Health Index/Environmental Factor (ASAS HI/EF) and to evaluate its reliability and validity in Korean patients with axial spondyloarthritis (SpA). A total of 43 patients participated. Translation an...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2014.29.3.334
更新日期:2014-03-01 00:00:00
abstract::A case of nerve sheath myxoma also called as neurothekeoma in a 33-year-old woman is described. The lesion appeared as a painful, elevated nodule on the scalp for several months, without an appreciable increase in size. Microscopically, it showed typical histologic characteristics of nerve sheath myxoma, and tumor cel...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1992.7.1.85
更新日期:1992-03-01 00:00:00
abstract::To determine the cytologic and histologic correlation of atypical glandular cells of undetermined significance (AGUS) in Papanicolaou smears, a cytology file from January 1998 to May 1999 was reviewed. Surgical pathology files were searched to determine which patients received subsequent biopsies. One hundred thirty-t...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2001.16.2.214
更新日期:2001-04-01 00:00:00
abstract::Deposition of basement membrane extracellular matrix is influenced by adjacent tumor cells, and in some cases, the pattern of type IV collagen deposit is characteristic in malignant tumors. In this report, we analyzed the difference in type IV collagen deposition patterns between benign and malignant phyllodes tumors ...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1992.7.4.360
更新日期:1992-12-01 00:00:00
abstract::Rearrangements of the subtelomeric regions of chromosomes account for a significant proportion of the underlying genetic defects in both idiopathic mental retardation (MR) and multiple congenital anomalies. To detect the rearrangements, a set of subtelomeric fluorescence in situ hybridization (FISH) probes has been de...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2008.23.4.573
更新日期:2008-08-01 00:00:00
abstract::Cardiothoracic ratio (CTR), the ratio of cardiac diameter (CD) to thoracic diameter (TD), is a useful screening method to detect cardiomegaly, but is reliable only on posteroanterior chest radiography (chest PA). We performed this cross-sectional 3-phase study to establish reliable CTR from anteroposterior chest radio...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2011.26.11.1446
更新日期:2011-11-01 00:00:00
abstract::Obese subjects are more prone to sudden deaths and arrhythmias than non-obese subjects. Heart rate turbulence (HRT) impairment reflects cardiac autonomic dysfunction, in particular impaired baroreflex sensitivity and reduced parasympathetic activity. Our aim was to evaluate the cardiac autonomic function in obesity by...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2007.22.4.629
更新日期:2007-08-01 00:00:00
abstract::Ionizing radiation produces reactive oxygen species, which exert diverse biological effects on cells and animals. We investigated alterations of heme oxygenase (HO) and non-protein thiols (NPSH), which are known as two major anti-oxidant enzymes, in female and male C57BL/6 mice in the lung, liver, and brain after whol...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2005.20.4.535
更新日期:2005-08-01 00:00:00
abstract::NAD(P)H oxidase plays an important role in hypertension and its complication in aldosterone-salt rat. We questioned whether NAD(P)H oxidase subunit expression and activity are modulated by aldosterone and whether this is associated with target-organ damage. Rats were infused with aldosterone (0.75 microg/hr/day) for 6...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2008.23.6.1039
更新日期:2008-12-01 00:00:00
abstract::Neuronal migration disorders (NMDs) constitute the main pathologic substrate of medically intractable epilepsy in human. This study is designed to investigate the changes in expression of glutamate receptor subtypes on radiation-induced NMD in rats. The lesion was produced by intrauterine irradiation (240 cGy) on E17 ...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2004.19.3.419
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Olfactory and gustatory dysfunction are frequently reported in patients with coronavirus disease 2019 (COVID-19). However, the reported prevalence of olfactory and/or gustatory dysfunction varies widely, and the reason for the inter-study differences is unclear. Hence, in this meta-analysis, we performed sub...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2021.36.e40
更新日期:2021-01-25 00:00:00
abstract::Primary immunodeficiency disease (PID) is a rare disorder in adults. Most often, serious forms are detected during infancy or childhood. However, mild forms of PID may not be diagnosed until later in life, and some types of humoral immunodeficiency may occur in adulthood. The purpose of this study was to identify clin...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2010.25.6.824
更新日期:2010-06-01 00:00:00
abstract::Although cervical epidural abscess is rare, it should be strongly suspected in any patient with unexplainable neck pain and fever, especially when the patient has a predisposing factor for this infectious process. The authors report a case of cervical epidural abscess in a 39-yr-old man with an aorto-duodenal fistula,...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2003.18.1.116
更新日期:2003-02-01 00:00:00
abstract::Terminal or interstitial deletions of Xp (Xp22.2→Xpter) in males have been recognized as a cause of contiguous gene syndromes showing variable association of apparently unrelated clinical manifestations such as Leri-Weill dyschondrosteosis (SHOX), chondrodysplasia punctata (CDPX1), mental retardation (NLGN4), ichthyos...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2012.27.10.1273
更新日期:2012-10-01 00:00:00
abstract::Initially, acute loss of smell (anosmia) and taste (ageusia) was not considered important symptoms for coronavirus disease 2019 (COVID-19). To determine the prevalence of these symptoms and to evaluate their diagnostic significance, we (approximately 150 physicians of the Daegu Medical Association) prospectively colle...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2020.35.e174
更新日期:2020-05-11 00:00:00
abstract::Allergen-specific immunotherapy (SIT) reduces allergen specific IgE (sIgE) levels and achieves clinical and immunological tolerance by modulating innate and adaptive immunological responses. Increased temperature and CO2 concentrations caused by climate changes contribute to an increase of pollen count and allergenici...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2014.29.7.1025
更新日期:2014-07-01 00:00:00
abstract::HIV-1 gp41 is an envelope protein that plays an essential role in virus entry. The mutation of gp41 affects HIV-1 entry and susceptibility to the fusion inhibitor T-20. Therefore, we analyzed the natural polymorphism of gp41 of 163 HIV-1 isolates from T-20-naïve Koreans infected with HIV-1. This study of gp41 polymorp...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2014.29.3.456
更新日期:2014-03-01 00:00:00
abstract::A case of aneurysmal ("angiomatoid") fibrous histiocytoma (AFH) in a 12-year-old girl is presented with its unusual clinicopathologic features. The lesion had the full microscopic characteristics of AFH described in prior reports, but it also had some features that differed from the original description of the disorde...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1989.4.4.159
更新日期:1989-12-01 00:00:00
abstract::In 2007, the Korean Interstitial Lung Disease Society had collected clinical data of patients who have diagnosed as Lymphangioleiomyomatosis (LAM) since 1990 through nationwide survey, which showed that LAM patients had increased sharply after 2004. The present study was performed to show the clinical features of Kore...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2010.25.8.1182
更新日期:2010-08-01 00:00:00
abstract::Cystic hypersecretory lesions of the breast are rare. These breast lesions include cystic hypersecretory hyperplasia (CHH), atypical CHH, and cystic hypersecretory carcinoma (CHC). The characteristic features are dilated ducts and cysts filled with thyroid colloid-like eosinophilic secretion. Only seven cases of invas...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2004.19.1.149
更新日期:2004-02-01 00:00:00
abstract::A rare case of gastric cancer associated with gastrojejunal and gastrocolic fistula is presented. A 56-year-old man who had been diagnosed with advanced gastric cancer(Borrmann's type III) 5 months previously was admitted due to watery diarrhea and frequent vomiting for 2 weeks. Fluoroscopic examination was visualized...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1996.11.5.437
更新日期:1996-10-01 00:00:00
abstract::The purpose of the study was to define characteristics of children with acute carbon monoxide poisoning. Eighty children hospitalized with acute carbon monoxide poisoning were recruited prospectively over a period of 12 months. Sociodemographic features, complaints and laboratory data were recorded. When the patient w...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2015.30.12.1836
更新日期:2015-12-01 00:00:00
abstract::Neuroblastomas originating from different sites might have different clinical and biological characteristics. In the present study, the clinical (age, sex and stage) and biological (N-myc amplification, Shimada pathology and levels of lactate dehydrogenase, ferritin and neuron-specific enolase) characteristics of pati...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2009.24.3.461
更新日期:2009-06-01 00:00:00
abstract::Although congenital renal tumors are rare, congenital mesoblastic nephroma (CMN) is the most common renal tumor in early infancy. It is non-metastatic, well differentiated, amenable to surgical removal, and carries a good prognosis. Polyhydramnios has been detected in most of the published cases of CMN. However, we ex...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2007.22.2.357
更新日期:2007-04-01 00:00:00
abstract::One important mechanism of drug resistance in acute leukemia is the overexpression of the multi-drug resistance (MDR1) gene that encodes a 170-kDa membrane protein called P-glycoprotein. To estimate the incidence and role of MDR1 gene expression in patients with acute leukemia, we investigated the expression of MDR1 b...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1998.13.6.617
更新日期:1998-12-01 00:00:00
abstract::Seasonal influenza is a significant cause of morbidity and mortality of children in Korea. However, few data are available on parental perception and action toward childhood influenza. This study aimed to characterize parental perception and patterns of action in response to influenza and influenza-like illnesses (ILI...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2017.32.2.204
更新日期:2017-02-01 00:00:00
abstract::Light chain deposition disease (LCDD) is a rare disorder associated with a clonal proliferation of plasma cells, which synthesize abnormal monoclonal immunoglobulin light chains. LCDD is characterized by systemic deposition of light chains in various organs, with the kidneys being most commonly affected. There have be...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2012.27.2.207
更新日期:2012-02-01 00:00:00
abstract::The increasing interest in healthcare and health screening events is revealing additional cases of asymptomatic isolated microscopic hematuria (IMH). However, a consensus of the evaluation and explanation of the IMH prognosis is controversial among physicians. Here, we present the natural course of IMH together with t...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2016.31.6.909
更新日期:2016-06-01 00:00:00