Upregulation of glutamate receptors in rat cerebral cortex with neuronal migration disorders.

Abstract:

:Neuronal migration disorders (NMDs) constitute the main pathologic substrate of medically intractable epilepsy in human. This study is designed to investigate the changes in expression of glutamate receptor subtypes on radiation-induced NMD in rats. The lesion was produced by intrauterine irradiation (240 cGy) on E17 rats, and then 10 weeks old rats were used for the study. The pathologic and immuno-histochemical findings for glutamate receptor subunit proteins on NMD cortex were correlated with development of behavioral seizures and EEG abnormality. Spontaneous seizures uncommonly occurred in NMD rats (5%); however, clinical stages of seizures were significantly increased in NMD rats by an administration of kainic acid. Brains taken from irradiated rats revealed gross and histopathologic features of NMD. Focal cortical dysplasia was identified by histopathology and immunohistochemistry with neurofilament protein (NF-M/H). Significantly strong NR1 and NR2A/B immunoreactivities were demonstrated in cytomegalic and heterotopic neurons of NMD rats. The results of the present study indicate that epileptogenesis of NMD might be caused by upregulation of glutamate receptor expression in dysplastic neurons of the rat cerebral cortex with NMDs.

journal_name

J Korean Med Sci

authors

Lee MC,Shim JJ,Kim JH,Kim MK,Woo YJ,Chung WK,Suh JJ,Nam SC,Lee JS,Kim YS,Kim JH,Kim HI

doi

10.3346/jkms.2004.19.3.419

keywords:

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

419-25

issue

3

eissn

1011-8934

issn

1598-6357

pii

200406419

journal_volume

19

pub_type

杂志文章
  • Clinical and genetic analysis of Korean patients with Miyoshi myopathy: identification of three novel mutations in the DYSF gene.

    abstract::Miyoshi myopathy (MM) is an autosomal recessive distal muscular dystrophy caused by mutations in the dysferlin gene (DYSF) on chromosome 2p13. Although MM patients and their mutations in the DYSF gene have been found from all over the world, there is only one report of genetically confirmed case of MM in Korea. Recent...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2006.21.4.724

    authors: Cho HJ,Sung DH,Kim EJ,Yoon CH,Ki CS,Kim JW

    更新日期:2006-08-01 00:00:00

  • Self-Expandable Metallic Stent Placement for the Palliation of Esophageal Cancer.

    abstract::Esophageal stents have been used to palliate patients with dysphagia caused by esophageal cancer. Early rigid plastic prostheses have been associated with a high risk of complications. However, with the development of self-expanding stents, it has developed into a widely accepted method for treating malignant esophage...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章,评审

    doi:10.3346/jkms.2017.32.7.1062

    authors: Kim KY,Tsauo J,Song HY,Kim PH,Park JH

    更新日期:2017-07-01 00:00:00

  • Clinical effectiveness of urinary human chorionic gonadotropin related protein (hCGRP) quantification for diagnosis of ectopic pregnancy.

    abstract::We detected pregnancy related new molecule, human chorionic gonadotropin related protein (hCGRP) in the urine of a pregnant women by using a monoclonal antibody against the human chorionic gonadotropin (hCG). This study examined the effectiveness of urinary hCGRP quantification in diagnosing ectopic pregnancy. This st...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2005.20.3.461

    authors: Lee JK,Oh MJ,Shin JS,Lee KJ,Nam JH,Cha JH,Chang JD,Cho DH,Kang IS,Lee PI

    更新日期:2005-06-01 00:00:00

  • A nationwide survey of lymphangioleiomyomatosis in Korea: recent increase in newly diagnosed patients.

    abstract::In 2007, the Korean Interstitial Lung Disease Society had collected clinical data of patients who have diagnosed as Lymphangioleiomyomatosis (LAM) since 1990 through nationwide survey, which showed that LAM patients had increased sharply after 2004. The present study was performed to show the clinical features of Kore...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2010.25.8.1182

    authors: Park HY,Nam HS,Chung MP,Jeong SH,Kim YJ,Cha SI,Kim YW,Park JS,Uh ST,Park CS,Park MS,Moon JA,Jung KS,Jegal YJ,Kim DS,Song JW,Yum HK,Park YB

    更新日期:2010-08-01 00:00:00

  • Heart Rate Change While Drowsy Driving.

    abstract::Heart rate (HR) change during sleepy driving has never been investigated. Healthy volunteers who planned to drive a long distance were recruited and monitored with a 24-hour Holter. Six healthy volunteers were enrolled. Their mean driving time was 297.7 ± 111 minutes. Mean duration of sleepy time while driving was 27 ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2019.34.e56

    authors: Jo SH,Kim JM,Kim DK

    更新日期:2019-02-12 00:00:00

  • Tempol attenuates renal fibrosis in mice with unilateral ureteral obstruction: the role of PI3K-Akt-FoxO3a signaling.

    abstract::This study investigated whether tempol, an anti-oxidant, protects against renal injury by modulating phosphatidylinositol 3-kinase (PI3K)-Akt-Forkhead homeobox O (FoxO) signaling. Mice received unilateral ureteral obstruction (UUO) surgery with or without administration of tempol. We evaluated renal damage, oxidative ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2014.29.2.230

    authors: Yoon HE,Kim SJ,Kim SJ,Chung S,Shin SJ

    更新日期:2014-02-01 00:00:00

  • Surgical management of mechanical valve thrombosis: twenty-six years' experience.

    abstract::In the present study, the authors investigated the management of mechanical valve thrombosis (MVT). From January 1981 through March 2006, 2,908 mechanical valve replacements were performed in 2,298 patients at our institution. Twenty (0.87%) patients presented with MVT, 14 (70.0%) were women, and the mean age of the p...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2008.23.3.378

    authors: Ahn H,Kim KH,Kim KC,Kim CY

    更新日期:2008-06-01 00:00:00

  • Adjustment of urinary mercury in health risk assessment of mercury.

    abstract::The determination of adjustment method of urinary mercury in spot urine is one of the important issues in assessing the health risks of mercury workers. But there have been debates about whether creatinine or other forms of correction for urinary concentration are better in reducing the variation of urinary mercury. W...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1996.11.4.319

    authors: Lee E,Park HK,Kim HJ

    更新日期:1996-08-01 00:00:00

  • Paradoxical increase of IgE binding components during allergen-specific immunotherapy in pollinosis patients.

    abstract::Allergen-specific immunotherapy (SIT) reduces allergen specific IgE (sIgE) levels and achieves clinical and immunological tolerance by modulating innate and adaptive immunological responses. Increased temperature and CO2 concentrations caused by climate changes contribute to an increase of pollen count and allergenici...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2014.29.7.1025

    authors: Kim MA,Yoon MG,Jin HJ,Shin YS,Park HS

    更新日期:2014-07-01 00:00:00

  • Corporeal blood gas changes according to duration of drug-induced prolonged erection.

    abstract::The corporeal blood gas changes in accordance with the duration of the prolonged erection which developed after intracorporeal pharmacotherapy with papaverine and phentolamine were investigated in 62 impotence patients. The picture of the corporeal blood taken from 15 psychogenic impotence patients (a control group) a...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1993.8.3.202

    authors: Kim SC,Seo KK,Oh CH

    更新日期:1993-06-01 00:00:00

  • Depression and Its Severity Are Strongly Associated with Both Storage and Voiding Lower Urinary Tract Symptoms Independently of Prostate Volume.

    abstract::Depression is related to various functional medical conditions. Its association with lower urinary tract symptoms (LUTS) is also expected. We evaluated whether depression and its severity are associated with LUTS when LUTS risk factors including prostate volume (PV) are taken into account in a large population of Kore...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2015.30.11.1646

    authors: Jeong SM,Suh B,Jang SH,Jin HS,Kim N,Kwon H,Cho B,Park JH

    更新日期:2015-11-01 00:00:00

  • Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock: a prospective observational study in 12 university hospitals in Korea.

    abstract::A prospective multicenter observational study was performed to investigate the epidemiology and outcomes of community-acquired severe sepsis and septic shock. Subjects included 1,192 adult patients admitted to the 22 participating intensive care units (ICUs) of 12 university hospitals in the Korean Sepsis Registry Sys...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章,多中心研究

    doi:10.3346/jkms.2012.27.11.1308

    authors: Park DW,Chun BC,Kim JM,Sohn JW,Peck KR,Kim YS,Choi YH,Choi JY,Kim SI,Eom JS,Kim HY,Song JY,Song YG,Choi HJ,Kim MJ

    更新日期:2012-11-01 00:00:00

  • Efficacy of the 'Children in Disaster: Evaluation and Recovery (CIDER)' Protocol for Traumatized Adolescents in Korea.

    abstract:BACKGROUND:We aimed to evaluate the feasibility of trauma-focused group therapy in adolescents exposed to traumatic events in Korea. METHODS:We recruited 22 adolescents (mean age, 16 years; standard deviation, 1.43; range, 13-18 years). Children in Disaster: Evaluation and Recovery (CIDER) V1.0 is a trauma-focused gro...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2020.35.e240

    authors: Lee MS,Kim HS,Park EJ,Bhang SY

    更新日期:2020-07-27 00:00:00

  • Determinants for heart rate variability in a normal Korean population.

    abstract::This study examined the normal ranges and the determinants for various parameters of the short-term heart rate variability (HRV) measurements in a large Korean sample of healthy people. HRV measurements were obtained in 2,748 healthy men and 735 healthy women 18-65 yr of age. The mean total power (TP), low frequency (...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2011.26.10.1293

    authors: Kim GM,Woo JM

    更新日期:2011-10-01 00:00:00

  • Myocutaneous flaps in general surgery.

    abstract::In recent developments in the repair of large surgical defects where simple flap rotation may have been previously employed, myocutaneous flaps are being used because of functional advantages and to decrease the number of reconstructive procedures. The authors have employed myocutaneous flaps in 40 cases from January ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1987.2.1.1

    authors: Park YK,Seel DJ

    更新日期:1987-03-01 00:00:00

  • Clinical and epidemiological comparison of human metapneumovirus and respiratory syncytial virus in seoul, Korea, 2003-2008.

    abstract::Human metapneumovirus (HMPV) shares clinical and epidemiological characteristics with well-known respiratory syncytial virus (RSV). The aim of this study was to investigate the clinical and epidemiological differences between HMPV- and RSV-induced wheezing illnesses. A total of 1,008 nasopharyngeal aspirate specimens ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2010.25.3.342

    authors: Kim CK,Choi J,Callaway Z,Kim HB,Chung JY,Koh YY,Shin BM

    更新日期:2010-03-01 00:00:00

  • Meningitis by Toxocara canis after ingestion of raw ostrich liver.

    abstract::Recently reports on toxocariasis are increasing by serodiagnosis in Korea. A previously healthy 17-yr-old boy complained of headache, fever, dyspnea, and anorexia. He showed symptoms and signs of eosinophilic meningitis with involvement of the lungs and liver. Specific IgG antibody to Toxocara canis larval antigen was...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2012.27.9.1105

    authors: Noh Y,Hong ST,Yun JY,Park HK,Oh JH,Kim YE,Jeon BS

    更新日期:2012-09-01 00:00:00

  • Relationship between maternal serum C-reactive protein, funisitis and early-onset neonatal sepsis.

    abstract::The aim of this study was to determine whether maternal serum C-reactive protein (CRP) is of value in predicting funisitis and early-onset neonatal sepsis (EONS) in women with preterm labor or preterm premature rupture of membranes (PROM). This retrospective cohort study included 306 consecutive women with preterm lab...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2012.27.6.674

    authors: Lee SY,Park KH,Jeong EH,Oh KJ,Ryu A,Park KU

    更新日期:2012-06-01 00:00:00

  • A case of myxedema coma presenting as a brain stem infarct in a 74-year-old Korean woman.

    abstract::Myxedema coma is the extreme form of untreated hypothyroidism. In reality, few patients present comatose with severe myxedema. We describe a patient with myxedema coma which was initially misdiagnosed as a brain stem infarct. She presented to the hospital with alteration of the mental status, generalized edema, hypoth...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2010.25.9.1394

    authors: Ahn JY,Kwon HS,Ahn HC,Sohn YD

    更新日期:2010-09-01 00:00:00

  • The Association between Involuntary Smoking Exposure with Urine Cotinine Level and Blood Cadmium Level in General Non-Smoking Populations.

    abstract::Unintentional environmental exposure to toxicants is associated with an aggravated health status of the general population. Involuntary smoking (IS) exposure is one of the main routes to involuntary toxicants exposure. However, few studies have attempted to understand the environmental cadmium exposure by IS exposure ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2017.32.4.568

    authors: Lee W,Lee S,Roh J,Won JU,Yoon JH

    更新日期:2017-04-01 00:00:00

  • Clinical features and treatment outcomes of upper gastrointestinal bleeding in patients with cirrhosis.

    abstract::With recent progress in treatment modalities, mortality from upper gastrointestinal (UGI) bleeding has decreased appreciably. The aim of this study was to establish how UGI bleeds are managed in Korean patients with cirrhosis and to evaluate treatment outcomes. A total of 479 episodes of acute UGI bleeding in 464 pati...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2008.23.4.635

    authors: Seo YS,Kim YH,Ahn SH,Yu SK,Baik SK,Choi SK,Heo J,Hahn T,Yoo TW,Cho SH,Lee HW,Kim JH,Cho M,Park SH,Kim BI,Han KH,Um SH

    更新日期:2008-08-01 00:00:00

  • First Imported Case of Zika Virus Infection into Korea.

    abstract::Since Zika virus has been spreading rapidly in the Americas from 2015, the outbreak of Zika virus infection becomes a global health emergency because it can cause neurological complications and adverse fetal outcome including microcephaly. Here, we report clinical manifestations and virus isolation findings from a cas...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2016.31.7.1173

    authors: Jang HC,Park WB,Kim UJ,Chun JY,Choi SJ,Choe PG,Jung SI,Jee Y,Kim NJ,Choi EH,Oh MD

    更新日期:2016-07-01 00:00:00

  • Application of Baveno Criteria and Modified Baveno Criteria with Shear-wave Elastography in Compensated Advanced Chronic Liver Disease.

    abstract:BACKGROUND:We aimed to validate Baveno VI and expanded Baveno VI criteria using two dimensional shear-wave elastography (2D-SWE) in compensated advanced chronic liver disease (cACLD) patients with alcohol as the main etiology. METHODS:Clinical data from 305 patients with cACLD who underwent a liver stiffness measureme...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2020.35.e249

    authors: Kang SH,Baik SK,Kim MY

    更新日期:2020-08-03 00:00:00

  • Characteristics of Children with Acute Carbon Monoxide Poisoning in Ankara: A Single Centre Experience.

    abstract::The purpose of the study was to define characteristics of children with acute carbon monoxide poisoning. Eighty children hospitalized with acute carbon monoxide poisoning were recruited prospectively over a period of 12 months. Sociodemographic features, complaints and laboratory data were recorded. When the patient w...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2015.30.12.1836

    authors: Unsal Sac R,Taşar MA,Bostancı İ,Şimşek Y,Bilge Dallar Y

    更新日期:2015-12-01 00:00:00

  • Compensation for occupational injuries and diseases in special populations: farmers and soldiers.

    abstract::Some types of workers such as farmers and soldiers are at a higher risk of work-related injury and illness than workers from other occupations. Despite this fact, they are not covered under the Industrial Safety Health (ISH) Act or the Industrial Accident Compensation Insurance (IACI) Act. The Safety Aid System for Fa...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2014.29.S.S24

    authors: Kwon YJ,Lee SJ

    更新日期:2014-06-01 00:00:00

  • The Immunogenicity and Safety of a Combined DTaP-IPV//Hib Vaccine Compared with Individual DTaP-IPV and Hib (PRP~T) Vaccines: a Randomized Clinical Trial in South Korean Infants.

    abstract::Recommended infant vaccination in Korea includes DTaP-IPV and Hib vaccines administered as separate injections. In this randomized, open, controlled study we assessed the non-inferiority of immunogenicity of DTaP-IPV//Hib pentavalent combination vaccine (Pentaxim™) compared with licensed DTaP-IPV and Hib (PRP~T) vacci...

    journal_title:Journal of Korean medical science

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3346/jkms.2016.31.9.1383

    authors: Kang JH,Lee HJ,Kim KH,Oh SH,Cha SH,Lee J,Kim NH,Eun BW,Kim CH,Hong YJ,Kim HH,Lee KY,Kim YJ,Cho EY,Kim HS,Guitton F,Ortiz E

    更新日期:2016-09-01 00:00:00

  • A case of successful surgical treatment of migraine headaches in a patient with sporadic pulmonary arteriovenous malformations.

    abstract::Pulmonary arteriovenous malformations (PAVMs) are thin-walled aneurysms caused by abnormal communication between the pulmonary arteries and veins. Migraine headaches are sometimes the presenting clinical manifestation of PAVMs. Although embolotherapy, using detachable balloons or stainless steel coils, is generally ac...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2009.24.2.330

    authors: Na SJ,Cho HM,Park JS

    更新日期:2009-04-01 00:00:00

  • Central pontine myelinolysis in a patient with acute lymphoblastic leukemia after hematopoietic stem cell transplantation: a case report.

    abstract::We describe a 37-yr-old man who developed central pontine myelinolysis (CPM) after allogeneic hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia. After HSCT, desquamation developed on the whole body accompanied by hyperbilirubinemia. The liver biopsy of the patient indicated graft-versus-h...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2008.23.2.324

    authors: Lim KH,Kim S,Lee YS,Kim KH,Kim J,Rhee Jy,Kim HJ,Yi HG,Oh SY,Lim JH,Han SW,Lee S,Kim I,Yoon SS,Park S,Kim BK

    更新日期:2008-04-01 00:00:00

  • LPS-induced migration of peritoneal B-1 cells is associated with upregulation of CXCR4 and increased migratory sensitivity to CXCL12.

    abstract::B-1 cells, which constitute a predominant lymphocyte subset in serosal cavities and produce most of natural antibodies, are subdivided into the CD5(+) B-1a and CD5(-) B-1b cell subpopulations, but the differential roles of B-1a and B-1b cells are not well understood. We report that B-1a cells preferentially migrate ou...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2012.27.1.27

    authors: Moon H,Lee JG,Shin SH,Kim TJ

    更新日期:2012-01-01 00:00:00

  • Prostate size correlates with fasting blood glucose in non-diabetic benign prostatic hyperplasia patients with normal testosterone levels.

    abstract::We evaluated the correlations between BMI, fasting glucose, insulin, testosterone level, insulin resistance, and prostate size in non-diabetic benign prostatic hyperplasia (BPH) patients with normal testosterone levels. Data from 212 non-diabetic BPH patients with normal testosterone levels, who underwent transurethra...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2011.26.9.1214

    authors: Kim WT,Yun SJ,Choi YD,Kim GY,Moon SK,Choi YH,Kim IY,Kim WJ

    更新日期:2011-09-01 00:00:00