Abstract:
:We study the statistical efficiency for rising-dose designs in the context of first-in-human studies. Specifically, we identify a class of crossover designs that are appealing in terms of both subject safety and statistical efficiency and, for a three-period, two-panel design in such a class, we compare its A-efficiency relative to the corresponding parallel designs and optimal/efficient crossover designs, respectively, under various plausible models. In the meantime, we also evaluate the impact of inclusion of baseline measurements as a covariate in the statistical analysis, for both crossover and parallel studies.
journal_name
J Biopharm Statjournal_title
Journal of biopharmaceutical statisticsauthors
Yan Z,Hosmane B,Locke Cdoi
10.1080/10543406.2013.792827subject
Has Abstractpub_date
2013-01-01 00:00:00pages
804-17issue
4eissn
1054-3406issn
1520-5711journal_volume
23pub_type
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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journal_title:Journal of biopharmaceutical statistics
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