Abstract:
:Parameter estimation following an adaptive design or group sequential design has been extremely challenging due to potential random high from its face value estimate. In this paper, we introduce a new framework to model clinical trial data flow based on a marked point process (MPP). The MPP model allows us to use methods of stochastic calculus for analyses of any adaptive clinical trial. As an example, we apply this method to a two stage treatment selection design and derive a procedure to estimate the treatment effect. Numerical examples will be used to evaluate the performance of the proposed procedure.
journal_name
J Biopharm Statjournal_title
Journal of biopharmaceutical statisticsauthors
Luo X,Li M,Shih WJ,Ouyang Pdoi
10.1080/10543406.2012.676534subject
Has Abstractpub_date
2012-01-01 00:00:00pages
700-18issue
4eissn
1054-3406issn
1520-5711journal_volume
22pub_type
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